temazepam has been researched along with Substance Withdrawal Syndrome in 25 studies
Temazepam: A benzodiazepine that acts as a GAMMA-AMINOBUTYRIC ACID modulator and anti-anxiety agent.
Substance Withdrawal Syndrome: Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.
| Excerpt | Relevance | Reference |
|---|---|---|
| ") in mice chronically treated with temazepam or diazepam induced the appearance of withdrawal signs: clonic seizures, tonic convulsions and death episodes." | 3.73 | Influence of adenosine receptor agonists on benzodiazepine withdrawal signs in mice. ( Fidecka, S; Listos, J; Malec, D, 2005) |
| " Only few controlled studies have characterized the effect of discontinuation of their chronic use on sleep and quality of life." | 2.90 | Withdrawal from long-term use of zopiclone, zolpidem and temazepam may improve perceived sleep and quality of life in older adults with primary insomnia. ( Kivelä, SL; Lähteenmäki, R; Neuvonen, PJ; Partinen, M; Puustinen, J; Räihä, I; Vahlberg, T, 2019) |
| "92 outpatients (≥55 years) with primary insomnia, long-term BZDA use as hypnotics (mean duration of BZDA use 9." | 2.87 | Long-term persistence of withdrawal of temazepam, zopiclone, and zolpidem in older adults: a 3-year follow-up study. ( Aarnio, P; Kivelä, SL; Lähteenmäki, R; Neuvonen, PJ; Nurminen, J; Partinen, M; Puustinen, J; Räihä, I; Vahlberg, T, 2018) |
| " As impaired muscle strength and balance are risk factors for falls, we examined the effects of hypnotic withdrawal on handgrip strength and balance in older adult outpatients during and after long-term use of temazepam, zopiclone and zolpidem (here collectively referred to as "benzodiazepines")." | 2.79 | Handgrip strength and balance in older adults following withdrawal from long-term use of temazepam, zopiclone or zolpidem as hypnotics. ( Kivelä, SL; Lähteenmäki, R; Lyles, A; Neuvonen, PJ; Nurminen, J; Partinen, M; Puustinen, J; Räihä, I; Vahlberg, T, 2014) |
| "With temazepam this effect was more variable, with total wake time increased only with the second withdrawal period (39%)." | 2.67 | Rebound insomnia after only brief and intermittent use of rapidly eliminated benzodiazepines. ( Bixler, EO; Fee, EC; Kales, A; Manfredi, RL; Vela-Bueno, A; Vgontzas, AN, 1991) |
| "There was no rebound insomnia when temazepam was withdrawn either abruptly or gradually in long-term hospitalised elderly patients and may not be effective as a long-term hypnotic." | 2.66 | Temazepam withdrawal in elderly hospitalized patients: a double blind randomised trial comparing abrupt versus gradual withdrawal. ( Brown, H; Taggart, HM; Tham, TC, 1989) |
| "Temazepam did not produce any behavioral side effects during either drug condition." | 2.66 | Quazepam and temazepam: effects of short- and intermediate-term use and withdrawal. ( Bixler, EO; Jacoby, JA; Kales, A; Kales, JD; Soldatos, CR; Vela-Bueno, A, 1986) |
| "Zopiclone was associated with feelings of being troubled, tense, antagonistic and bored whereas temazepam produced drowsiness, clumsiness, dreaminess and sadness." | 2.66 | Subjective effects during administration and on discontinuation of zopiclone and temazepam in normal subjects. ( Frcka, G; Lader, M, 1987) |
| "Rebound insomnia, a worsening of sleep compared with pretreatment levels, has been reported upon discontinuation of short half-life benzodiazepine hypnotics." | 2.38 | Rebound insomnia: a critical review. ( Gillin, JC; Johnson, LC; Spinweber, CL, 1989) |
| "Flurazepam is a long elimination half-life drug, and there is significant daytime sedation during short term use; with continued use this effect diminishes." | 2.36 | Sleep laboratory studies of hypnotic drugs: efficacy and withdrawal effects. ( Kales, A; Kales, JD, 1983) |
| "However, withdrawal symptoms may occur in patients receiving recommended doses and/or short-term therapy." | 2.36 | Benzodiazepine withdrawal syndrome: a literature review and evaluation. ( MacKinnon, GL; Parker, WA, 1982) |
| "The aim of this study was to assess the effect of withdrawal from the long-term use of temazepam, zopiclone or zolpidem as hypnotics drugs (here referred to as BZD) on cognitive performance." | 1.40 | Effect of withdrawal from long-term use of temazepam, zopiclone or zolpidem as hypnotic agents on cognition in older adults. ( Kivelä, SL; Lähteenmäki, R; Lyles, A; Neuvonen, PJ; Partinen, M; Polo-Kantola, P; Puustinen, J; Räihä, I; Salo, P; Vahlberg, T, 2014) |
| "Temazepam, 7." | 1.29 | Temazepam 7.5 mg: effects on sleep in elderly insomniacs. ( Bixler, EO; Kales, A; Myers, DC; Vgontzas, AN, 1994) |
| "Dogs, surgically implanted with a chronic gastric fistula, were chronically dosed with N-desmethyldiazepam (32 mg/kg/day) in four divided doses to attain N-desmethyldiazepam plasma levels comparable to those observed in dogs dependent on diazepam (60 mg/kg/day)." | 1.27 | N-desmethyldiazepam physical dependence in dogs. ( Martin, WR; McNicholas, LF; Pruitt, TA, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (52.00) | 18.7374 |
| 1990's | 5 (20.00) | 18.2507 |
| 2000's | 1 (4.00) | 29.6817 |
| 2010's | 6 (24.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Puustinen, J | 4 |
| Lähteenmäki, R | 4 |
| Nurminen, J | 2 |
| Vahlberg, T | 4 |
| Aarnio, P | 1 |
| Partinen, M | 4 |
| Räihä, I | 4 |
| Neuvonen, PJ | 4 |
| Kivelä, SL | 4 |
| Downes, MA | 1 |
| Sadler, CW | 1 |
| Vidler, S | 1 |
| Lovett, CJ | 1 |
| Polo-Kantola, P | 1 |
| Salo, P | 1 |
| Lyles, A | 2 |
| Parameswaran, R | 1 |
| Moore, K | 1 |
| Hannan, T | 1 |
| Austin, M | 1 |
| Listos, J | 1 |
| Malec, D | 1 |
| Fidecka, S | 1 |
| Linnoila, M | 1 |
| Viukari, M | 1 |
| Lamminsivu, U | 1 |
| Auvinen, J | 1 |
| Ratna, L | 1 |
| Kales, A | 5 |
| Kales, JD | 3 |
| MacKinnon, GL | 1 |
| Parker, WA | 1 |
| Conell, LJ | 1 |
| Berlin, RM | 1 |
| Vgontzas, AN | 2 |
| Bixler, EO | 4 |
| Myers, DC | 1 |
| Manfredi, RL | 1 |
| Vela-Bueno, A | 2 |
| Fee, EC | 1 |
| Drake, J | 2 |
| Dusci, LJ | 1 |
| Good, SM | 1 |
| Hall, RW | 1 |
| Ilett, KF | 1 |
| Gillin, JC | 1 |
| Spinweber, CL | 1 |
| Johnson, LC | 1 |
| Yutrzenka, GJ | 1 |
| Patrick, GA | 1 |
| Rosenberger, W | 1 |
| Tham, TC | 1 |
| Brown, H | 1 |
| Taggart, HM | 1 |
| Soldatos, CR | 1 |
| Jacoby, JA | 1 |
| Lader, M | 1 |
| Frcka, G | 1 |
| Brubaker, BH | 1 |
| McNicholas, LF | 1 |
| Martin, WR | 1 |
| Pruitt, TA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Development of a Coordinated, Community-Based Medication Management Model for Home-Dwelling Aged in Primary Care[NCT02545257] | 191 participants (Actual) | Interventional | 2015-09-30 | Completed | |||
| Addressing Nocturnal Sleep/Wake Effects on Risk of Suicide in Older Adults (ANSWERS-OA): A Pilot, Open-Label, Randomized Controlled Trial of Digital Cognitive Behavioral Therapy for Insomnia[NCT04986007] | 70 participants (Anticipated) | Interventional | 2021-09-01 | Enrolling by invitation | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for temazepam and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Sleep laboratory studies of hypnotic drugs: efficacy and withdrawal effects.
Topics: Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Anxiety; Dose-Response Relationship, Drug; Fl | 1983 |
Benzodiazepine withdrawal syndrome: a literature review and evaluation.
Topics: Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Dose-Response Relationship, Drug; Humans; Lorazepam | 1982 |
Rebound insomnia: a critical review.
Topics: Anti-Anxiety Agents; Flurazepam; Humans; Sleep Initiation and Maintenance Disorders; Sleep Stages; S | 1989 |
8 trials available for temazepam and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Long-term persistence of withdrawal of temazepam, zopiclone, and zolpidem in older adults: a 3-year follow-up study.
Topics: Aged; Azabicyclo Compounds; Double-Blind Method; Female; Follow-Up Studies; Humans; Hypnotics and Se | 2018 |
Withdrawal from long-term use of zopiclone, zolpidem and temazepam may improve perceived sleep and quality of life in older adults with primary insomnia.
Topics: Aged; Aged, 80 and over; Azabicyclo Compounds; Double-Blind Method; Female; Humans; Hypnotics and Se | 2019 |
Handgrip strength and balance in older adults following withdrawal from long-term use of temazepam, zopiclone or zolpidem as hypnotics.
Topics: Aged; Aged, 80 and over; Azabicyclo Compounds; Female; Follow-Up Studies; Hand Strength; Humans; Hyp | 2014 |
Efficacy and side effects of lorazepam, oxazepam, and temazepam as sleeping aids in psychogeriatric inpatients.
Topics: Aged; Anti-Anxiety Agents; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Lorazepam; | 1980 |
Rebound insomnia after only brief and intermittent use of rapidly eliminated benzodiazepines.
Topics: Adult; Female; Humans; Male; Middle Aged; Monitoring, Physiologic; Random Allocation; Sleep Initiati | 1991 |
Temazepam withdrawal in elderly hospitalized patients: a double blind randomised trial comparing abrupt versus gradual withdrawal.
Topics: Aged; Aged, 80 and over; Anti-Anxiety Agents; Confusion; Double-Blind Method; Female; Humans; Inpati | 1989 |
Quazepam and temazepam: effects of short- and intermediate-term use and withdrawal.
Topics: Adult; Aged; Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Drug Evaluation; Half-L | 1986 |
Subjective effects during administration and on discontinuation of zopiclone and temazepam in normal subjects.
Topics: Adult; Anti-Anxiety Agents; Anxiety; Arousal; Azabicyclo Compounds; Female; Humans; Hypnotics and Se | 1987 |
14 other studies available for temazepam and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Difficult to sedate case of acute behavioural disturbance secondary to baclofen withdrawal.
Topics: Adult; Antipsychotic Agents; Baclofen; Benzodiazepines; Diazepam; Droperidol; Humans; Male; Problem | 2019 |
Effect of withdrawal from long-term use of temazepam, zopiclone or zolpidem as hypnotic agents on cognition in older adults.
Topics: Aged; Azabicyclo Compounds; Cognition; Female; Follow-Up Studies; Humans; Hypnotics and Sedatives; M | 2014 |
Effect of withdrawal from long-term use of temazepam, zopiclone or zolpidem as hypnotic agents on cognition in older adults.
Topics: Aged; Azabicyclo Compounds; Cognition; Female; Follow-Up Studies; Humans; Hypnotics and Sedatives; M | 2014 |
Effect of withdrawal from long-term use of temazepam, zopiclone or zolpidem as hypnotic agents on cognition in older adults.
Topics: Aged; Azabicyclo Compounds; Cognition; Female; Follow-Up Studies; Humans; Hypnotics and Sedatives; M | 2014 |
Effect of withdrawal from long-term use of temazepam, zopiclone or zolpidem as hypnotic agents on cognition in older adults.
Topics: Aged; Azabicyclo Compounds; Cognition; Female; Follow-Up Studies; Humans; Hypnotics and Sedatives; M | 2014 |
Catatonia associated with temazepam withdrawal.
Topics: Aged; Anti-Anxiety Agents; Catatonia; Female; Humans; Substance Withdrawal Syndrome; Temazepam | 2011 |
Influence of adenosine receptor agonists on benzodiazepine withdrawal signs in mice.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodi | 2005 |
Addiction to temazepam.
Topics: Adult; Anti-Anxiety Agents; Humans; Male; Substance Withdrawal Syndrome; Substance-Related Disorders | 1981 |
Withdrawal after substitution of a short-acting for a long-acting benzodiazepine.
Topics: Anti-Anxiety Agents; Anxiety; Chronic Disease; Delayed-Action Preparations; Diazepam; Flurazepam; Ha | 1983 |
Systematic review of the benzodiazepines. Guidelines for data sheets on diazepam, chlordiazepoxide, medazepam, clorazepate, lorazepam, oxazepam, temazepam, triazolam, nitrazepam, and flurazepam. Committee on the Review of Medicines.
Topics: Benzodiazepines; Chlordiazepoxide; Clorazepate Dipotassium; Diazepam; Flurazepam; Humans; Lorazepam; | 1980 |
Temazepam 7.5 mg: effects on sleep in elderly insomniacs.
Topics: Aged; Anxiety; Chronic Disease; Electroencephalography; Electrooculography; Female; Humans; Male; Sl | 1994 |
Temazepam 'Planpak': a multicentre general practice trial in planned benzodiazepine hypnotic withdrawal.
Topics: Adult; Aged; Benzodiazepines; Consumer Behavior; Drug Administration Schedule; Family Practice; Fema | 1991 |
Temazepam 'Planpak', a fixed-dose reduction regimen for withdrawing benzodiazepine hypnotics: results of a general practice survey.
Topics: Adolescent; Adult; Aged; Benzodiazepines; Consumer Behavior; Drug Administration Schedule; Family Pr | 1991 |
Excretion of diazepam and its metabolites in human milk during withdrawal from combination high dose diazepam and oxazepam.
Topics: Adult; Diazepam; Drug Combinations; Female; Humans; Infant; Milk, Human; Nordazepam; Oxazepam; Subst | 1990 |
Substitution of temazepam and midazolam in pentobarbital-dependent rats.
Topics: Animals; Anti-Anxiety Agents; Arousal; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred St | 1989 |
Adverse reactions to benzodiazepine hypnotics: spontaneous reporting system.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Anti-Anxiety Agents; Female; Flurazepam; Humans; Hypnot | 1987 |
N-desmethyldiazepam physical dependence in dogs.
Topics: Analysis of Variance; Animals; Body Weight; Diazepam; Dogs; Drinking; Energy Intake; Female; Lorazep | 1985 |