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temazepam and Substance Withdrawal Syndrome

temazepam has been researched along with Substance Withdrawal Syndrome in 25 studies

Temazepam: A benzodiazepine that acts as a GAMMA-AMINOBUTYRIC ACID modulator and anti-anxiety agent.

Substance Withdrawal Syndrome: Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.

Research Excerpts

ExcerptRelevanceReference
") in mice chronically treated with temazepam or diazepam induced the appearance of withdrawal signs: clonic seizures, tonic convulsions and death episodes."3.73Influence of adenosine receptor agonists on benzodiazepine withdrawal signs in mice. ( Fidecka, S; Listos, J; Malec, D, 2005)
" Only few controlled studies have characterized the effect of discontinuation of their chronic use on sleep and quality of life."2.90Withdrawal from long-term use of zopiclone, zolpidem and temazepam may improve perceived sleep and quality of life in older adults with primary insomnia. ( Kivelä, SL; Lähteenmäki, R; Neuvonen, PJ; Partinen, M; Puustinen, J; Räihä, I; Vahlberg, T, 2019)
"92 outpatients (≥55 years) with primary insomnia, long-term BZDA use as hypnotics (mean duration of BZDA use 9."2.87Long-term persistence of withdrawal of temazepam, zopiclone, and zolpidem in older adults: a 3-year follow-up study. ( Aarnio, P; Kivelä, SL; Lähteenmäki, R; Neuvonen, PJ; Nurminen, J; Partinen, M; Puustinen, J; Räihä, I; Vahlberg, T, 2018)
" As impaired muscle strength and balance are risk factors for falls, we examined the effects of hypnotic withdrawal on handgrip strength and balance in older adult outpatients during and after long-term use of temazepam, zopiclone and zolpidem (here collectively referred to as "benzodiazepines")."2.79Handgrip strength and balance in older adults following withdrawal from long-term use of temazepam, zopiclone or zolpidem as hypnotics. ( Kivelä, SL; Lähteenmäki, R; Lyles, A; Neuvonen, PJ; Nurminen, J; Partinen, M; Puustinen, J; Räihä, I; Vahlberg, T, 2014)
"With temazepam this effect was more variable, with total wake time increased only with the second withdrawal period (39%)."2.67Rebound insomnia after only brief and intermittent use of rapidly eliminated benzodiazepines. ( Bixler, EO; Fee, EC; Kales, A; Manfredi, RL; Vela-Bueno, A; Vgontzas, AN, 1991)
"There was no rebound insomnia when temazepam was withdrawn either abruptly or gradually in long-term hospitalised elderly patients and may not be effective as a long-term hypnotic."2.66Temazepam withdrawal in elderly hospitalized patients: a double blind randomised trial comparing abrupt versus gradual withdrawal. ( Brown, H; Taggart, HM; Tham, TC, 1989)
"Temazepam did not produce any behavioral side effects during either drug condition."2.66Quazepam and temazepam: effects of short- and intermediate-term use and withdrawal. ( Bixler, EO; Jacoby, JA; Kales, A; Kales, JD; Soldatos, CR; Vela-Bueno, A, 1986)
"Zopiclone was associated with feelings of being troubled, tense, antagonistic and bored whereas temazepam produced drowsiness, clumsiness, dreaminess and sadness."2.66Subjective effects during administration and on discontinuation of zopiclone and temazepam in normal subjects. ( Frcka, G; Lader, M, 1987)
"Rebound insomnia, a worsening of sleep compared with pretreatment levels, has been reported upon discontinuation of short half-life benzodiazepine hypnotics."2.38Rebound insomnia: a critical review. ( Gillin, JC; Johnson, LC; Spinweber, CL, 1989)
"Flurazepam is a long elimination half-life drug, and there is significant daytime sedation during short term use; with continued use this effect diminishes."2.36Sleep laboratory studies of hypnotic drugs: efficacy and withdrawal effects. ( Kales, A; Kales, JD, 1983)
"However, withdrawal symptoms may occur in patients receiving recommended doses and/or short-term therapy."2.36Benzodiazepine withdrawal syndrome: a literature review and evaluation. ( MacKinnon, GL; Parker, WA, 1982)
"The aim of this study was to assess the effect of withdrawal from the long-term use of temazepam, zopiclone or zolpidem as hypnotics drugs (here referred to as BZD) on cognitive performance."1.40Effect of withdrawal from long-term use of temazepam, zopiclone or zolpidem as hypnotic agents on cognition in older adults. ( Kivelä, SL; Lähteenmäki, R; Lyles, A; Neuvonen, PJ; Partinen, M; Polo-Kantola, P; Puustinen, J; Räihä, I; Salo, P; Vahlberg, T, 2014)
"Temazepam, 7."1.29Temazepam 7.5 mg: effects on sleep in elderly insomniacs. ( Bixler, EO; Kales, A; Myers, DC; Vgontzas, AN, 1994)
"Dogs, surgically implanted with a chronic gastric fistula, were chronically dosed with N-desmethyldiazepam (32 mg/kg/day) in four divided doses to attain N-desmethyldiazepam plasma levels comparable to those observed in dogs dependent on diazepam (60 mg/kg/day)."1.27N-desmethyldiazepam physical dependence in dogs. ( Martin, WR; McNicholas, LF; Pruitt, TA, 1985)

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-199013 (52.00)18.7374
1990's5 (20.00)18.2507
2000's1 (4.00)29.6817
2010's6 (24.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Puustinen, J4
Lähteenmäki, R4
Nurminen, J2
Vahlberg, T4
Aarnio, P1
Partinen, M4
Räihä, I4
Neuvonen, PJ4
Kivelä, SL4
Downes, MA1
Sadler, CW1
Vidler, S1
Lovett, CJ1
Polo-Kantola, P1
Salo, P1
Lyles, A2
Parameswaran, R1
Moore, K1
Hannan, T1
Austin, M1
Listos, J1
Malec, D1
Fidecka, S1
Linnoila, M1
Viukari, M1
Lamminsivu, U1
Auvinen, J1
Ratna, L1
Kales, A5
Kales, JD3
MacKinnon, GL1
Parker, WA1
Conell, LJ1
Berlin, RM1
Vgontzas, AN2
Bixler, EO4
Myers, DC1
Manfredi, RL1
Vela-Bueno, A2
Fee, EC1
Drake, J2
Dusci, LJ1
Good, SM1
Hall, RW1
Ilett, KF1
Gillin, JC1
Spinweber, CL1
Johnson, LC1
Yutrzenka, GJ1
Patrick, GA1
Rosenberger, W1
Tham, TC1
Brown, H1
Taggart, HM1
Soldatos, CR1
Jacoby, JA1
Lader, M1
Frcka, G1
Brubaker, BH1
McNicholas, LF1
Martin, WR1
Pruitt, TA1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Development of a Coordinated, Community-Based Medication Management Model for Home-Dwelling Aged in Primary Care[NCT02545257]191 participants (Actual)Interventional2015-09-30Completed
Addressing Nocturnal Sleep/Wake Effects on Risk of Suicide in Older Adults (ANSWERS-OA): A Pilot, Open-Label, Randomized Controlled Trial of Digital Cognitive Behavioral Therapy for Insomnia[NCT04986007]70 participants (Anticipated)Interventional2021-09-01Enrolling by invitation
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for temazepam and Substance Withdrawal Syndrome

ArticleYear
Sleep laboratory studies of hypnotic drugs: efficacy and withdrawal effects.
    Journal of clinical psychopharmacology, 1983, Volume: 3, Issue:2

    Topics: Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Anxiety; Dose-Response Relationship, Drug; Fl

1983
Benzodiazepine withdrawal syndrome: a literature review and evaluation.
    The American journal of drug and alcohol abuse, 1982, Volume: 9, Issue:1

    Topics: Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Dose-Response Relationship, Drug; Humans; Lorazepam

1982
Rebound insomnia: a critical review.
    Journal of clinical psychopharmacology, 1989, Volume: 9, Issue:3

    Topics: Anti-Anxiety Agents; Flurazepam; Humans; Sleep Initiation and Maintenance Disorders; Sleep Stages; S

1989

Trials

8 trials available for temazepam and Substance Withdrawal Syndrome

ArticleYear
Long-term persistence of withdrawal of temazepam, zopiclone, and zolpidem in older adults: a 3-year follow-up study.
    BMC geriatrics, 2018, 06-15, Volume: 18, Issue:1

    Topics: Aged; Azabicyclo Compounds; Double-Blind Method; Female; Follow-Up Studies; Humans; Hypnotics and Se

2018
Withdrawal from long-term use of zopiclone, zolpidem and temazepam may improve perceived sleep and quality of life in older adults with primary insomnia.
    Basic & clinical pharmacology & toxicology, 2019, Volume: 124, Issue:3

    Topics: Aged; Aged, 80 and over; Azabicyclo Compounds; Double-Blind Method; Female; Humans; Hypnotics and Se

2019
Handgrip strength and balance in older adults following withdrawal from long-term use of temazepam, zopiclone or zolpidem as hypnotics.
    BMC geriatrics, 2014, Nov-21, Volume: 14

    Topics: Aged; Aged, 80 and over; Azabicyclo Compounds; Female; Follow-Up Studies; Hand Strength; Humans; Hyp

2014
Efficacy and side effects of lorazepam, oxazepam, and temazepam as sleeping aids in psychogeriatric inpatients.
    International pharmacopsychiatry, 1980, Volume: 15, Issue:2

    Topics: Aged; Anti-Anxiety Agents; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Lorazepam;

1980
Rebound insomnia after only brief and intermittent use of rapidly eliminated benzodiazepines.
    Clinical pharmacology and therapeutics, 1991, Volume: 49, Issue:4

    Topics: Adult; Female; Humans; Male; Middle Aged; Monitoring, Physiologic; Random Allocation; Sleep Initiati

1991
Temazepam withdrawal in elderly hospitalized patients: a double blind randomised trial comparing abrupt versus gradual withdrawal.
    Irish journal of medical science, 1989, Volume: 158, Issue:12

    Topics: Aged; Aged, 80 and over; Anti-Anxiety Agents; Confusion; Double-Blind Method; Female; Humans; Inpati

1989
Quazepam and temazepam: effects of short- and intermediate-term use and withdrawal.
    Clinical pharmacology and therapeutics, 1986, Volume: 39, Issue:3

    Topics: Adult; Aged; Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Drug Evaluation; Half-L

1986
Subjective effects during administration and on discontinuation of zopiclone and temazepam in normal subjects.
    Pharmacopsychiatry, 1987, Volume: 20, Issue:2

    Topics: Adult; Anti-Anxiety Agents; Anxiety; Arousal; Azabicyclo Compounds; Female; Humans; Hypnotics and Se

1987

Other Studies

14 other studies available for temazepam and Substance Withdrawal Syndrome

ArticleYear
Difficult to sedate case of acute behavioural disturbance secondary to baclofen withdrawal.
    Emergency medicine Australasia : EMA, 2019, Volume: 31, Issue:3

    Topics: Adult; Antipsychotic Agents; Baclofen; Benzodiazepines; Diazepam; Droperidol; Humans; Male; Problem

2019
Effect of withdrawal from long-term use of temazepam, zopiclone or zolpidem as hypnotic agents on cognition in older adults.
    European journal of clinical pharmacology, 2014, Volume: 70, Issue:3

    Topics: Aged; Azabicyclo Compounds; Cognition; Female; Follow-Up Studies; Humans; Hypnotics and Sedatives; M

2014
Effect of withdrawal from long-term use of temazepam, zopiclone or zolpidem as hypnotic agents on cognition in older adults.
    European journal of clinical pharmacology, 2014, Volume: 70, Issue:3

    Topics: Aged; Azabicyclo Compounds; Cognition; Female; Follow-Up Studies; Humans; Hypnotics and Sedatives; M

2014
Effect of withdrawal from long-term use of temazepam, zopiclone or zolpidem as hypnotic agents on cognition in older adults.
    European journal of clinical pharmacology, 2014, Volume: 70, Issue:3

    Topics: Aged; Azabicyclo Compounds; Cognition; Female; Follow-Up Studies; Humans; Hypnotics and Sedatives; M

2014
Effect of withdrawal from long-term use of temazepam, zopiclone or zolpidem as hypnotic agents on cognition in older adults.
    European journal of clinical pharmacology, 2014, Volume: 70, Issue:3

    Topics: Aged; Azabicyclo Compounds; Cognition; Female; Follow-Up Studies; Humans; Hypnotics and Sedatives; M

2014
Catatonia associated with temazepam withdrawal.
    The Australian and New Zealand journal of psychiatry, 2011, Volume: 45, Issue:11

    Topics: Aged; Anti-Anxiety Agents; Catatonia; Female; Humans; Substance Withdrawal Syndrome; Temazepam

2011
Influence of adenosine receptor agonists on benzodiazepine withdrawal signs in mice.
    European journal of pharmacology, 2005, Oct-31, Volume: 523, Issue:1-3

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodi

2005
Addiction to temazepam.
    British medical journal (Clinical research ed.), 1981, Jun-06, Volume: 282, Issue:6279

    Topics: Adult; Anti-Anxiety Agents; Humans; Male; Substance Withdrawal Syndrome; Substance-Related Disorders

1981
Withdrawal after substitution of a short-acting for a long-acting benzodiazepine.
    JAMA, 1983, Nov-25, Volume: 250, Issue:20

    Topics: Anti-Anxiety Agents; Anxiety; Chronic Disease; Delayed-Action Preparations; Diazepam; Flurazepam; Ha

1983
Systematic review of the benzodiazepines. Guidelines for data sheets on diazepam, chlordiazepoxide, medazepam, clorazepate, lorazepam, oxazepam, temazepam, triazolam, nitrazepam, and flurazepam. Committee on the Review of Medicines.
    British medical journal, 1980, Mar-29, Volume: 280, Issue:6218

    Topics: Benzodiazepines; Chlordiazepoxide; Clorazepate Dipotassium; Diazepam; Flurazepam; Humans; Lorazepam;

1980
Temazepam 7.5 mg: effects on sleep in elderly insomniacs.
    European journal of clinical pharmacology, 1994, Volume: 46, Issue:3

    Topics: Aged; Anxiety; Chronic Disease; Electroencephalography; Electrooculography; Female; Humans; Male; Sl

1994
Temazepam 'Planpak': a multicentre general practice trial in planned benzodiazepine hypnotic withdrawal.
    Current medical research and opinion, 1991, Volume: 12, Issue:6

    Topics: Adult; Aged; Benzodiazepines; Consumer Behavior; Drug Administration Schedule; Family Practice; Fema

1991
Temazepam 'Planpak', a fixed-dose reduction regimen for withdrawing benzodiazepine hypnotics: results of a general practice survey.
    Current medical research and opinion, 1991, Volume: 12, Issue:6

    Topics: Adolescent; Adult; Aged; Benzodiazepines; Consumer Behavior; Drug Administration Schedule; Family Pr

1991
Excretion of diazepam and its metabolites in human milk during withdrawal from combination high dose diazepam and oxazepam.
    British journal of clinical pharmacology, 1990, Volume: 29, Issue:1

    Topics: Adult; Diazepam; Drug Combinations; Female; Humans; Infant; Milk, Human; Nordazepam; Oxazepam; Subst

1990
Substitution of temazepam and midazolam in pentobarbital-dependent rats.
    Physiology & behavior, 1989, Volume: 46, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Arousal; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred St

1989
Adverse reactions to benzodiazepine hypnotics: spontaneous reporting system.
    Pharmacology, 1987, Volume: 35, Issue:5

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Anti-Anxiety Agents; Female; Flurazepam; Humans; Hypnot

1987
N-desmethyldiazepam physical dependence in dogs.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 235, Issue:2

    Topics: Analysis of Variance; Animals; Body Weight; Diazepam; Dogs; Drinking; Energy Intake; Female; Lorazep

1985