telocinobufagin and Kidney-Diseases

Cardiotonic steroids (CTS) are Na⁺/K⁺-ATPase (NKA) ligands that are elevated in volume-expanded states and associated with cardiac and renal dysfunction in both clinical and experimental settings. We test the hypothesis that the CTS telocinobufagin (TCB) promotes renal dysfunction in a process involving signaling through the NKA α-1 in the following studies. First, we infuse TCB (4 weeks at 0.1 µg/g/day) or a vehicle into mice expressing wild-type (WT) NKA α-1, as well as mice with a genetic reduction (~40%) of NKA α-1 (NKA α-1

Topics: Animals; Bufanolides; Cell Line; Fibrosis; Glycogen Synthase Kinase 3 beta; Kidney Diseases; MAP Kinase Signaling System; Mice; Ouabain; Phosphorylation; Signal Transduction; Sodium-Potassium-Exchanging ATPase; Swine