tellurium and Melanoma

To determine the influence of weight, height, gender, age, heart rate, and blood pressure on count rate in cadmium-zinc-telluride single-photon emission computed tomography (CZT SPECT) gated radionuclide angiography.. A total of 1,065 eligible patients referred for routine assessment of left ventricular ejection fraction were registered from August 2015 to November 2016. Data were recorded on heart rate, systolic and diastolic blood pressure, age, gender, height, weight, and count rate. All radionuclide angiographies were performed on a dedicated cardiac CZT SPECT camera, GE Discovery 530c. A dose of 550 MBq. Count rate varied from 1.2 to 8.9 counts per second. All test variables were significantly associated with count rate. From the preliminary analysis, weight appeared as the main contributing factor for explaining the variations in count rate with and R. Patient height, weight, gender, and age have significant impact on count rate when performing CZT radionuclide angiography and may subsequently be used for individualized planning of tracer dosage.

Topics: Adolescent; Adult; Aged; Aged, 80 and over; Angiography; Anthropometry; Blood Pressure; Breast Neoplasms; Cadmium; Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography; Cardiomyopathies; Female; Heart Rate; Humans; Kidney Neoplasms; Liver Neoplasms; Lymphoma, Large B-Cell, Diffuse; Male; Melanoma; Middle Aged; Ovarian Neoplasms; Quality Control; Regression Analysis; Retrospective Studies; Tellurium; Young Adult; Zinc

Traditional physicochemical approaches for the synthesis of compounds, drugs, and nanostructures developed as potential solutions for antimicrobial resistance or against cancer treatment are, for the most part, facile and straightforward. Nevertheless, these approaches have several limitations, such as the use of toxic chemicals and production of toxic by-products with limited biocompatibility. Therefore, new methods are needed to address these limitations, and green chemistry offers a suitable and novel answer, with the safe and environmentally friendly design, manufacturing, and use of minimally toxic chemicals. Green chemistry approaches are especially useful for the generation of metallic nanoparticles or nanometric structures that can effectively and efficiently address health care concerns.. Here, tellurium (Te) nanowires were synthesized using a novel green chemistry approach, and their structures and cytocompatibility were evaluated.. An easy and straightforward hydrothermal method was employed, and the Te nanowires were characterized using transmission electron microscopy, scanning electron microscopy, energy-dispersive X-ray spectroscopy, Fourier-transform infrared spectroscopy, X-ray powder diffraction, X-ray photoelectron spectroscopy, and optical microscopy for morphology, size, and chemistry. Cytotoxicity tests were performed with human dermal fibroblasts and human melanoma cells (to assess anticancer properties). The results showed that a treatment with Te nanowires at concentrations between 5 and 100 μg/mL improved the proliferation of healthy cells and decreased cancerous cell growth over a 5-day period. Most importantly, the green chemistry -synthesized Te nanowires outperformed those produced by traditional synthetic chemical methods.. This study suggests that green chemistry approaches for producing Te nanostructures may not only reduce adverse environmental effects resulting from traditional synthetic chemistry methods, but also be more effective in numerous health care applications.

Topics: Antineoplastic Agents; Cell Death; Cell Line, Tumor; Fibroblasts; Green Chemistry Technology; Humans; Inhibitory Concentration 50; Melanoma; Metal Nanoparticles; Nanowires; Photoelectron Spectroscopy; Spectrometry, X-Ray Emission; Spectroscopy, Fourier Transform Infrared; Tellurium; X-Ray Diffraction

Fluorescent quantum dots (QDs) used for biomedical imaging and diagnostics have attracted considerable attention over the past decade. Here, we report our finding regarding the therapeutic efficacy of the popularly used red/brown, brown or close to black CdTe and CdSe QDs. Upon 671-nm laser irradiation, these QDs can rapidly convert light energy into heat, both in vitro and in vivo. In the present study, the growth of mouse melanoma tumors injected with CdTe(710) QDs coated with a silica shell (SiO(2)) was significantly inhibited after laser irradiation, with eventual disappearance of the tumor. In contrast, tumors injected with the silica-coated QDs without subsequent irradiation continued to grow over time. They had a growth rate close to that of tumors injected with SiO(2) or phosphate-buffered saline, with or without laser irradiation. In conclusion, our data suggest that the popularly used CdTe and CdSe QDs have great potential in the treatment of cancer using photothermal therapy.

Topics: Animals; Cadmium Compounds; Cell Line, Tumor; Humans; Lasers; Light; Liver; Melanoma; Mice; Mice, Inbred BALB C; Optics and Photonics; Photochemistry; Quantum Dots; Reactive Oxygen Species; Selenium Compounds; Skin Neoplasms; Tellurium; Temperature; Time Factors

The authors assembled a prototype compact gamma-ray imaging probe (MediPROBE) for sentinel lymph node (SLN) localization. This probe is based on a semiconductor pixel detector. Its basic performance was assessed in the laboratory and clinically in comparison with a conventional gamma camera.. The room-temperature CdTe pixel detector (1 mm thick) has 256 x 256 square pixels arranged with a 55 microm pitch (sensitive area 14.08 x 14.08 mm2), coupled pixel-by-pixel via bump-bonding to the Medipix2 photon-counting readout CMOS integrated circuit. The imaging probe is equipped with a set of three interchangeable knife-edge pinhole collimators (0.94, 1.2, or 2.1 mm effective diameter at 140 keV) and its focal distance can be regulated in order to set a given field of view (FOV). A typical FOV of 70 mm at 50 mm skin-to-collimator distance corresponds to a minification factor 1:5. The detector is operated at a single low-energy threshold of about 20 keV.. For 99 mTc, at 50 mm distance, a background-subtracted sensitivity of 6.5 x 10(-3) cps/kBq and a system spatial resolution of 5.5 mm FWHM were obtained for the 0.94 mm pinhole; corresponding values for the 2.1 mm pinhole were 3.3 x 10(-2) cps/kBq and 12.6 mm. The dark count rate was 0.71 cps. Clinical images in three patients with melanoma indicate detection of the SLNs with acquisition times between 60 and 410 s with an injected activity of 26 MBq 99 mTc and prior localization with standard gamma camera lymphoscintigraphy.. The laboratory performance of this imaging probe is limited by the pinhole collimator performance and the necessity of working in minification due to the limited detector size. However, in clinical operative conditions, the CdTe imaging probe was effective in detecting SLNs with adequate resolution and an acceptable sensitivity. Sensitivity is expected to improve with the future availability of a larger CdTe detector permitting operation at shorter distances from the patient skin.

Topics: Cadmium Compounds; Cluster Analysis; Gamma Cameras; Humans; Lymph Nodes; Melanoma; Organotechnetium Compounds; Radionuclide Imaging; Semiconductors; Software; Tellurium

In novel treatment approaches, therapeutics should be designed to target cancer stem cells (CSCs). Quantum dots (QDs) are a promising new tool in fighting against cancer. However, little is known about accumulation and cytotoxicity of QDs in CSCs.. Accumulation and cytotoxicity of CdTe-MPA (mercaptopropionic acid) QDs in CSCs were assessed using flow cytometry and fluorescence-activated cell sorting techniques as well as a colorimetric cell viability assay.. We investigated the expression of two cell surface-associated glycoproteins, CD44 and CD133, in four different cancer cell lines (glioblastoma, melanoma, pancreatic, and prostate adenocarcinoma). Only the melanoma cells were positive to both markers of CD44 and CD133, whereas the other cells were only CD44-positive. The QDs accumulated to a similar extent in all subpopulations of the melanoma cells. The phenotypical response after QD treatment was compared with the response after ionizing radiation treatment. The percentage of the CD44(high-)CD133(high) subpopulation decreased from 72% to 55%-58% for both treatments. The stem-like subpopulation CD44(high)CD133(low/-) increased from 26%-28% in the untreated melanoma cells to 36%-40% for both treatments.. Treatment of melanoma cells with QDs results in an increase of stem-like cell subpopulations. The changes in phenotype distribution of the melanoma cells after the treatment with QDs are comparable with the changes after ionizing radiation.

Topics: 3-Mercaptopropionic Acid; AC133 Antigen; Antigens, CD; Biomarkers, Tumor; Cadmium Compounds; Cell Line, Tumor; Cell Survival; Flow Cytometry; Glioblastoma; Glycoproteins; Humans; Hyaluronan Receptors; Male; Melanoma; Neoplastic Stem Cells; Pancreatic Neoplasms; Peptides; Phenotype; Prostatic Neoplasms; Quantum Dots; Tellurium