tellurium and Friedreich-Ataxia

tellurium has been researched along with Friedreich-Ataxia* in 1 studies

Other Studies

1 other study(ies) available for tellurium and Friedreich-Ataxia

Article	Year
Low iron concentration and aconitase deficiency in a yeast frataxin homologue deficient strain. FEBS letters, 1999, Aug-06, Volume: 456, Issue:2 Deletion of the yeast frataxin homologue, YFH1, elicits accumulation of iron in mitochondria and mitochondrial defects. We report here that in the presence of an iron chelator in the culture medium, the concentration of iron in mitochondria is the same in wild-type and YFH1 deletant strains. Under these conditions, the activity of the respiratory complexes is restored. However, the activity of the mitochondrial aconitase, a 4Fe-4S cluster-containing protein, remains low. The frataxin family bears homology to a bacterial protein family which confers resistance to tellurium, a metal closely related to sulfur. Yfh1p might control the synthesis of iron-sulfur clusters in mitochondria. Topics: Aconitate Hydratase; Amino Acid Sequence; Drug Resistance, Microbial; Frataxin; Friedreich Ataxia; Fungal Proteins; Gene Deletion; Genes, Fungal; Humans; Iron; Iron-Binding Proteins; Mitochondria; Molecular Sequence Data; Oxygen Consumption; Phosphotransferases (Alcohol Group Acceptor); Saccharomyces cerevisiae; Sequence Homology, Amino Acid; Tellurium	1999

Article

Year

Low iron concentration and aconitase deficiency in a yeast frataxin homologue deficient strain.

FEBS letters, 1999, Aug-06, Volume: 456, Issue:2

Deletion of the yeast frataxin homologue, YFH1, elicits accumulation of iron in mitochondria and mitochondrial defects. We report here that in the presence of an iron chelator in the culture medium, the concentration of iron in mitochondria is the same in wild-type and YFH1 deletant strains. Under these conditions, the activity of the respiratory complexes is restored. However, the activity of the mitochondrial aconitase, a 4Fe-4S cluster-containing protein, remains low. The frataxin family bears homology to a bacterial protein family which confers resistance to tellurium, a metal closely related to sulfur. Yfh1p might control the synthesis of iron-sulfur clusters in mitochondria.

Topics: Aconitate Hydratase; Amino Acid Sequence; Drug Resistance, Microbial; Frataxin; Friedreich Ataxia; Fungal Proteins; Gene Deletion; Genes, Fungal; Humans; Iron; Iron-Binding Proteins; Mitochondria; Molecular Sequence Data; Oxygen Consumption; Phosphotransferases (Alcohol Group Acceptor); Saccharomyces cerevisiae; Sequence Homology, Amino Acid; Tellurium

1999