tellurium and Cardiomyopathy--Hypertrophic

通过碲锌镉心脏专用单光子发射计算机断层成像术（CZT-SPECT）动态心肌血流定量显像发现一肥厚型心肌病患者左心室整体及冠状动脉分支区域冠状动脉血流储备值均降低，提示该患者冠状动脉微血管生理功能异常，其对准确诊断和评估肥厚型心肌病具有重要的补充价值，同时对此类患者的治疗及预后评估具有重要的参考价值。.

Topics: Cardiomyopathy, Hypertrophic; Humans; Perfusion; Tellurium; Tomography, Emission-Computed, Single-Photon

The spectrum dynamics (SD) algorithm is a cardiac reconstruction algorithm of D-SPECT, which improves spatial resolution compared with the ordered-subsets expectation maximization (OSEM) algorithm. We evaluated the wall thickness and left ventricular (LV) volume in patients with hypertrophic cardiomyopathy (HCM) using the SD algorithm.. In a phantom study, the myocardial wall was scanned with varying wall thicknesses (10-40 mm). In the clinical study, 30 and 27 normal and HCM patients underwent myocardial perfusion imaging.. In a phantom study, LV volume using the SD algorithm was increased by thickening the wall of the phantom. In the clinical study, the wall thickness and LV volume of OSEM and SD algorithms showed a difference between HCM and normal groups. The wall thickness using OSEM and SD algorithms were 19.4 ± 2.0 and 16.7 ± 1.5 mm in patients with normal, and 27.9 ± 4.9 and 21.8 ± 2.6 mm in patients with HCM.. The SD algorithm in cases of HCM may not be able to correctly assess wall thickness and LV volume. Our study suggests that the OSEM is more suitable in cases of HCM than the SD algorithm.

Topics: Aged; Aged, 80 and over; Algorithms; Cadmium; Cardiomyopathy, Hypertrophic; Cohort Studies; Female; Heart Ventricles; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Myocardial Perfusion Imaging; Phantoms, Imaging; Tellurium; Tomography, Emission-Computed, Single-Photon; Zinc