tellurium and Carcinoma--Ductal--Breast

The purpose of this study was to evaluate a small semiconductor-based gamma camera that may have applications in scintimammography.. A small cadmium zinc telluride (CZT) detector was evaluated. The detector had a field of view of 20 x 20 cm with detector elements of 2.5 x 2.5 mm in size. Both short-bore (35 mm) and long-bore (50 mm) collimators, matched to the geometry of the detector elements, were evaluated. The imaging performance of the CZT detector was compared with that of a conventional gamma camera equipped with all-purpose and ultra-high-resolution collimators. The performance of both systems with respect to breast imaging was evaluated using a water tank containing small glass spheres, 1.8-9.8 mm in diameter. The effects of variations in breast thickness, tumor depth, and tumor-to-background ratio were all simulated in this phantom model. Total counts per image were adjusted to approximate the count density observed in clinical scintimammographic studies.. Sensitivity of the CZT detector was 76% that of the equivalent NaI system. The system demonstrated excellent integral uniformity. The energy resolution of the CZT system was 6.5% for (99m)Tc. Spatial resolution with the long-bore collimator was superior to that of a conventional large field-of -view gamma camera equipped with an ultra-high- resolution collimator, over the range 0-6 cm from the collimator face. A blinded review of breast phantom images showed that small spheres (< or =7 mm in diameter) were better seen and had a better tumor-to-background ratio with the CZT system than with the conventional gamma camera.. A small CZT detector offers superior performance to a conventional gamma camera and should permit reliable detection of breast tumors <1 cm in size.

Topics: Breast; Breast Neoplasms; Cadmium Compounds; Carcinoma, Ductal, Breast; Equipment Design; Gamma Cameras; Humans; Phantoms, Imaging; Quality Control; Radiometry; Radionuclide Imaging; Reproducibility of Results; Sensitivity and Specificity; Tellurium; Transducers; Zinc