teixobactin has been researched along with Keratitis* in 1 studies
1 other study(ies) available for teixobactin and Keratitis
| Article | Year |
|---|---|
Design and Syntheses of Highly Potent Teixobactin Analogues against Staphylococcus aureus, Methicillin-Resistant Staphylococcus aureus (MRSA), and Vancomycin-Resistant Enterococci (VRE) in Vitro and in Vivo.
The cyclic depsipeptide, teixobactin, kills a number of Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), and Mycobacterium tuberculosis without detectable resistance. To date, teixobactin is the only molecule in its class that has shown in vivo antibacterial efficacy. In this work, we designed and synthesized 10 new in vivo ready teixobactin analogues. These analogues showed highly potent antibacterial activities against Staphylococcus aureus, MRSA, and vancomycin-resistant enterococci (VRE) in vitro. One analogue, d-Arg Topics: Animals; Depsipeptides; Drug Design; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Keratitis; Methicillin-Resistant Staphylococcus aureus; Mice; Staphylococcal Infections; Staphylococcus aureus; Vancomycin Resistance; Vancomycin-Resistant Enterococci | 2018 |