teixobactin and Escherichia-coli-Infections

teixobactin has been researched along with Escherichia-coli-Infections* in 1 studies

Other Studies

1 other study(ies) available for teixobactin and Escherichia-coli-Infections

ArticleYear
Efficient total syntheses and biological activities of two teixobactin analogues.
    Chemical communications (Cambridge, England), 2016, Apr-26, Volume: 52, Issue:36

    The discovery of the new antibiotic teixobactin has been timely in the race for unearthing novel antibiotics wherein the emergence of drug resistant bacteria poses a serious threat worldwide. Herein, we present the total syntheses and biological activities of two teixobactin analogues. This approach is simple, efficient and has several advantages: it uses commercially available building blocks (except AllocHN-d-Thr-OH), has a single purification step and a good recovery (22%). By using this approach we have synthesised two teixobactin analogues and established that the d-amino acids are critical for the antimicrobial activity of these analogues. With continuing high expectations from teixobactin, this work can be regarded as a stepping stone towards an in depth study of teixobactin, its analogues and the quest for synthesising similar molecules.

    Topics: Anti-Bacterial Agents; Bacteria; Depsipeptides; Escherichia coli; Escherichia coli Infections; Humans; Microbial Sensitivity Tests; Staphylococcal Infections; Staphylococcus aureus; Structure-Activity Relationship

2016