tegaserod and Inflammation

tegaserod has been researched along with Inflammation* in 1 studies

Other Studies

1 other study(ies) available for tegaserod and Inflammation

Article	Year
Discovery of selective nonpeptidergic neuropeptide FF2 receptor agonists. Journal of medicinal chemistry, 2009, Nov-12, Volume: 52, Issue:21 We report the discovery and initial characterization of a novel class of selective NPFF2 agonists. HTS screening using R-SAT, a whole cell based functional assay, identified a class of aryliminoguanidines as NPFF1 and NPFF2 ligands. Subsequent optimization led to molecules exhibiting selective NPFF2 agonistic activity. Systemic administration showed that selective NPFF2 agonists (1 and 3) are active in various pain models in vivo, whereas administration of a nonselective NPFF1 and NPFF2 agonist (9) increases sensitivity to noxious and non-noxious stimuli. Topics: Analgesics; Animals; Carrageenan; Guanidines; Humans; In Vitro Techniques; Inflammation; Microsomes, Liver; Pain; Pain Measurement; Peripheral Nervous System Diseases; Rats; Receptors, Neuropeptide	2009

Article

Year

Discovery of selective nonpeptidergic neuropeptide FF2 receptor agonists.

Journal of medicinal chemistry, 2009, Nov-12, Volume: 52, Issue:21

We report the discovery and initial characterization of a novel class of selective NPFF2 agonists. HTS screening using R-SAT, a whole cell based functional assay, identified a class of aryliminoguanidines as NPFF1 and NPFF2 ligands. Subsequent optimization led to molecules exhibiting selective NPFF2 agonistic activity. Systemic administration showed that selective NPFF2 agonists (1 and 3) are active in various pain models in vivo, whereas administration of a nonselective NPFF1 and NPFF2 agonist (9) increases sensitivity to noxious and non-noxious stimuli.

Topics: Analgesics; Animals; Carrageenan; Guanidines; Humans; In Vitro Techniques; Inflammation; Microsomes, Liver; Pain; Pain Measurement; Peripheral Nervous System Diseases; Rats; Receptors, Neuropeptide

2009