tegafur has been researched along with Sarcoma 180 in 21 studies
Sarcoma 180: An experimental sarcoma of mice.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The bioavailability of UK-21 given p." | 1.28 | Antitumor activity of two novel low immunosuppressive fluoropyrimidines UK-21 and UK-25. ( Kato, T; Kitaichi, K; Koda, A; Mori, H; Sakamoto, O, 1992) |
| "Tegafur is a typical masked compound transformed into 5-FU by the hepatic drug-metabolizing enzyme P-450." | 1.27 | [Effects of krestin (PSK) on drug-metabolizing enzymes with special reference to the activation of FT-207]. ( Fujita, H; Ikuzawa, M; Kawai, Y; Matsuki, M; Muto, S; Nakajima, S; Ogawa, K; Shimamura, M; Togawa, M; Yoshikumi, C, 1986) |
| " At the 1st hr after dosing the 5-FU level in the small intestine was close to, but that in other tissues was much lower than, the 5-FU level in the tumor of both types." | 1.26 | Tissue distribution of 5'-deoxy-5-fluorouridine and derived 5-fluorouracil in tumor-bearing mice and rats. ( Fukazawa, H; Hongu, Y; Ichihara, S; Shimizu, H; Suzuki, S, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (71.43) | 18.7374 |
| 1990's | 3 (14.29) | 18.2507 |
| 2000's | 3 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yasumoto, M | 1 |
| Yamawaki, I | 1 |
| Marunaka, T | 1 |
| Hashimoto, S | 1 |
| Lin, TS | 1 |
| Wang, L | 1 |
| Antonini, I | 1 |
| Cosby, LA | 1 |
| Shiba, DA | 1 |
| Kirkpatrick, DL | 1 |
| Sartorelli, AC | 1 |
| Cook, AF | 1 |
| Holman, MJ | 1 |
| Kramer, MJ | 1 |
| Suzuki, Y | 1 |
| Ishibiki, Y | 1 |
| Kawai, K | 2 |
| Sasaki, M | 1 |
| Matsuda, M | 1 |
| Watanabe, T | 1 |
| Shirasaka, T | 4 |
| Kamano, T | 2 |
| Yurimoto, S | 1 |
| Miyakawa, A | 1 |
| Okuzawa, A | 1 |
| Sakamoto, S | 1 |
| Sakamoto, K | 1 |
| Hosoda, S | 1 |
| Yuan, H | 1 |
| Song, J | 1 |
| Li, X | 1 |
| Li, N | 1 |
| Dai, J | 1 |
| Sasaki, K | 1 |
| Furusawa, S | 1 |
| Monma, K | 1 |
| Takayanagi, G | 1 |
| Nakamura, H | 2 |
| Yu-Qin, W | 1 |
| Miyauchi, S | 1 |
| Nishioka, N | 1 |
| Tanaka, H | 1 |
| Harada, N | 1 |
| Fujii, S | 4 |
| Ishitsuka, H | 2 |
| Miwa, M | 2 |
| Takemoto, K | 1 |
| Fukuoka, K | 1 |
| Itoga, A | 1 |
| Maruyama, HB | 1 |
| Suzuki, S | 1 |
| Hongu, Y | 1 |
| Fukazawa, H | 1 |
| Ichihara, S | 1 |
| Shimizu, H | 1 |
| Kitano, S | 2 |
| Ikenaka, K | 2 |
| Fukushima, M | 1 |
| Maehara, Y | 2 |
| Kanazawa, Y | 1 |
| Kurogi, S | 1 |
| Shinohara, S | 1 |
| Noda, Y | 1 |
| Masuda, K | 1 |
| Sakamoto, O | 1 |
| Mori, H | 1 |
| Kitaichi, K | 1 |
| Koda, A | 1 |
| Kato, T | 1 |
| Emi, Y | 1 |
| Kohnoe, S | 1 |
| Yoshida, M | 1 |
| Takahashi, I | 1 |
| Sugimachi, K | 1 |
| Ono, M | 1 |
| Eda, H | 1 |
| Fukuda, H | 1 |
| Fujimoto, K | 1 |
| Fujita, H | 2 |
| Ogawa, K | 2 |
| Ikuzawa, M | 2 |
| Muto, S | 2 |
| Matsuki, M | 2 |
| Nakajima, S | 2 |
| Shimamura, M | 2 |
| Togawa, M | 2 |
| Yoshikumi, C | 2 |
| Kawai, Y | 2 |
| Aoike, A | 1 |
| Hosokawa, T | 1 |
| Koyama, K | 1 |
| Rokutan, K | 1 |
| Nishi, Y | 1 |
| Yoshida, A | 1 |
| Nakamura, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 1b Dose Escalation Trial of PSK®/Placebo With Docetaxel to Treat Metastatic Castration-resistant Prostate Cancer[NCT01685489] | Phase 1 | 0 participants (Actual) | Interventional | 2013-05-31 | Withdrawn (stopped due to funding sequestered) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
21 other studies available for tegafur and Sarcoma 180
| Article | Year |
|---|---|
Studies on antitumor agents, 2. Syntheses and antitumor activities of 1-(tetrahydro-2-furanyl)-5-fluorouracil and 1,3-bis(tetrahydro-2-furanyl)-5-fluorouracil.
Topics: Animals; Antineoplastic Agents; Carcinoma 256, Walker; Carcinoma, Ehrlich Tumor; Fluorouracil; Letha | 1978 |
(o- and p-Nitrobenzyloxycarbonyl)-5-fluorouracil derivatives as potential conjugated bioreductive alkylating agents.
Topics: Animals; Cells, Cultured; Chemical Phenomena; Chemistry; Fluorouracil; Leukemia P388; Mice; Neoplasm | 1986 |
Fluorinated pyrimidine nucleosides. 4. Synthesis and antitumor testing of a series of 2',5'-dideoxy- and 2',3',5'-trideoxynucleosides of 5-fluorouracil.
Topics: Animals; Antineoplastic Agents; Deoxyuridine; Floxuridine; Fluorouracil; Mice; Sarcoma 180; Tegafur | 1980 |
Effect of combination of TS-1 and low-dose cisplatin on sarcoma-180 mouse sarcoma.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Area Under | 2003 |
Enhancement of the anti-tumor activity of S-1 by low-dose cisplatin in mice bearing the sarcoma-180 model.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Cisplatin; Drug Combinations; | 2005 |
Immunomodulation and antitumor activity of kappa-carrageenan oligosaccharides.
Topics: Animals; Antibody Formation; Antineoplastic Agents; Carrageenan; Cell Line, Tumor; Cytokines; Dose-R | 2006 |
Potentiation of the antitumor activity of tegafur in sarcoma 180-bearing mice by chlordiazepoxide, diazepam and oxazepam.
Topics: Animals; Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Drug Synergism; Fluorouracil; Male; Mice; | 1983 |
[Studies on the mechanism of antitumor activity of 5-FU and its derivatives--relationship between the inhibition of tumor growth and the inhibition of thymidylate synthetase in vivo].
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Division; DNA, | 1984 |
Role of uridine phosphorylase for antitumor activity of 5'-deoxy-5-fluorouridine.
Topics: Animals; Biotransformation; Floxuridine; Fluorouracil; Leukemia L1210; Male; Mice; Pentosyltransfera | 1980 |
Tissue distribution of 5'-deoxy-5-fluorouridine and derived 5-fluorouracil in tumor-bearing mice and rats.
Topics: Animals; Carcinoma 256, Walker; Female; Floxuridine; Fluorouracil; Male; Mice; Rats; Sarcoma 180; Te | 1980 |
Effect of coadministration of thymine or thymidine on the antitumor activity of 1-(2-tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Biodegradation, Environmental; Drug Synergism; | 1980 |
In vivo 19F NMR comparative study of 5-fluorouracil, 1-(2-tetrahydrofuryl)-5-fluorouracil (FT) and an FT-uracil coadministration system in mouse tumors.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Fluorine; Fluorouracil; Liver; Magnetic Res | 1994 |
Effect of coadministration of uracil or cytosine on the anti-tumor activity of clinical doses of 1-(2-tetrahydrofuryl)-5-fluorouracil and level of 5-fluorouracil in rodents.
Topics: Administration, Oral; Animals; Cytosine; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Li | 1979 |
Antitumor activity of two novel low immunosuppressive fluoropyrimidines UK-21 and UK-25.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Body Weight; Fluorouracil; Glycine; Leukemia L | 1992 |
Hyperthermia enhances the inhibition of tumor growth by 1-(2-tetrahydrofuryl)-5-fluorouracil/uracil (1:4) in tumors in mice and humans.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Combined Modality Therapy; D | 1992 |
[Effect of cepharanthine on antitumor activity of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT-207)--5-fluorouracil delivery into tumor tissue].
Topics: Alkaloids; Animals; Benzylisoquinolines; Drug Therapy, Combination; Fluorouracil; In Vitro Technique | 1989 |
[BOF-A1 and BOF-A2, new 5-FU degradation-inhibitory agents].
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Floxuridine; Fluorou | 1987 |
[Comparative studies on the antitumor activity of the fluorinated pyrimidines 5'-DFUR, tegafur, UFT and FUra on various murine tumors].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Floxuridine; Fluorouraci | 1988 |
[Effects of krestin (PSK) on drug-metabolizing enzymes with special reference to the activation of FT-207].
Topics: Aminopyrine; Animals; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochromes b5; Fluorourac | 1986 |
Effect of PSK, a protein-bound polysaccharide from Coriolus versicolor, on drug-metabolizing enzymes in sarcoma-180 bearing and normal mice.
Topics: Adjuvants, Immunologic; Animals; Antibiotics, Antineoplastic; Female; Fluorouracil; Liver; Mice; Mic | 1988 |
[Effect of fluoropyrimidine, drugs of tegafur and UFT on transplanted tumor in liver-damaged mice].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carbon Tetrachloride Poisoning; Chemical an | 1988 |