tegafur has been researched along with Reticulum Cell-Like Sarcoma, Yoshida in 14 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " As a single agent, S-1 showed higher antitumor activity with its low intestinal toxicity compared to continuous venous infusion 5-FU, the most effective dosing method of 5-FU, and/or to clinically available oral fluoropyrimidines such as UFT, doxyfluridine and capecitabine on various murine tumors and human tumor xenografts." | 1.33 | [Antitumor activity and function of S-1, a new oral tegafur-based formulation]. ( Fukushima, M, 2006) |
| "Methods for pharmacokinetic modulation of the plasma 5-fluorouracil (5-FU) level to increase antitumor activity during continuous venous infusion (CVI) of low doses of 5-FU were examined in Yoshida sarcoma-bearing rats." | 1.28 | Pharmacokinetic modulation of plasma 5-fluorouracil concentrations to potentiate the antitumor activity of continuous venous infusion of 5-fluorouracil. ( Fujii, S; Fukushima, M; Shimamoto, Y; Shirasaka, T, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (42.86) | 18.7374 |
| 1990's | 5 (35.71) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yasumoto, M | 1 |
| Yamawaki, I | 1 |
| Marunaka, T | 1 |
| Hashimoto, S | 1 |
| Fukushima, M | 6 |
| Shirasaka, T | 8 |
| Fujii, S | 4 |
| Kitano, S | 1 |
| Ikenaka, K | 1 |
| Nakamura, H | 1 |
| Maehara, Y | 1 |
| Miyauchi, S | 1 |
| Imaoka, T | 1 |
| Utsunomiya, T | 1 |
| Hayashi, K | 1 |
| Kubo, M | 1 |
| Kawaguchi, T | 1 |
| Matsui, Y | 1 |
| Omura, K | 1 |
| Hashimoto, T | 1 |
| Kawakami, K | 1 |
| Kanehira, E | 1 |
| Watanabe, T | 1 |
| Hirano, K | 1 |
| Watanabe, S | 1 |
| Watanabe, Y | 1 |
| Takechi, T | 1 |
| Nakano, K | 1 |
| Uchida, J | 2 |
| Mita, A | 1 |
| Toko, K | 1 |
| Takeda, S | 1 |
| Unemi, N | 1 |
| Shimamoto, Y | 3 |
| Kato, T | 2 |
| Yonekura, R | 1 |
| Ohshimo, H | 1 |
| Yoshisue, K | 1 |
| Masuda, H | 1 |
| Matsushima, E | 1 |
| Ikeda, K | 1 |
| Nagayama, S | 1 |
| Kawaguchi, Y | 1 |
| Araki, H | 1 |
| Kamiyama, Y | 1 |
| Tane, S | 1 |
| Ogawa, Y | 1 |
| Kido, Y | 1 |
| Naruko, M | 1 |
| Niwa, H | 1 |
| Abe, Y | 1 |
| Kobayashi, M | 1 |
| Mori, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase III Trial of S-1 and Cisplatin (3 Weekly) Versus S-1 and Oxaliplatin Combination Chemotherapy for First Line Treatment of Advanced Gastric Cancer[NCT01671449] | Phase 3 | 338 participants (Actual) | Interventional | 2012-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for tegafur and Reticulum Cell-Like Sarcoma, Yoshida
| Article | Year |
|---|---|
[Invention of a tumor-selective 5-fluorouracil derivative named S-1 by biochemical modulation of 5-fluorouracil].
Topics: Animals; Anorexia; Antimetabolites, Antineoplastic; Diarrhea; Dogs; Drug Combinations; Female; Fluor | 1998 |
13 other studies available for tegafur and Reticulum Cell-Like Sarcoma, Yoshida
| Article | Year |
|---|---|
Studies on antitumor agents, 2. Syntheses and antitumor activities of 1-(tetrahydro-2-furanyl)-5-fluorouracil and 1,3-bis(tetrahydro-2-furanyl)-5-fluorouracil.
Topics: Animals; Antineoplastic Agents; Carcinoma 256, Walker; Carcinoma, Ehrlich Tumor; Fluorouracil; Letha | 1978 |
[Antitumor activity and function of S-1, a new oral tegafur-based formulation].
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy | 2006 |
[Regulation of enzyme activities involved in pyrimidine synthesis and its application to cancer chemotherapy].
Topics: Administration, Oral; Animals; Deoxyuridine; Dihydrouracil Dehydrogenase (NAD+); DNA, Neoplasm; Drug | 1984 |
Effect of coadministration of thymine or thymidine on the antitumor activity of 1-(2-tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Biodegradation, Environmental; Drug Synergism; | 1980 |
Oral administration of BOF-A2 to rats with lung transplanted tumors results in increased 5-fluorouracil levels.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Disease Models, Animal; Drug Combinations; Dru | 1994 |
[Innate resistance to thymidylate synthase inhibition after 5-fluorouracil treatment--a rationale of combined use of cisplatin and its optimal administration dose].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Synergism; Fluorouracil; Ma | 1994 |
Antitumor activity and low intestinal toxicity of S-1, a new formulation of oral tegafur, in experimental tumor models in rats.
Topics: Animals; Antimetabolites, Antineoplastic; Colonic Neoplasms; Drug Combinations; Drug Screening Assay | 1997 |
Anticancer activity and toxicity of S-1, an oral combination of tegafur and two biochemical modulators, compared with continuous i.v. infusion of 5-fluorouracil.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Cell Division; Colorectal Neoplasms; | 1998 |
Tissue distribution and biotransformation of potassium oxonate after oral administration of a novel antitumor agent (drug combination of tegafur, 5-chloro-2,4-dihydroxypyridine, and potassium oxonate) to rats.
Topics: Administration, Oral; Allopurinol; Animals; Antimetabolites, Antineoplastic; Area Under Curve; Biotr | 2000 |
Effect of consecutive lower-dose cisplatin in enhancement of 5-fluorouracil cytotoxicity in experimental tumor cells in vivo.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Antineoplastic Combined Chemothe | 2000 |
Pharmacokinetic modulation of plasma 5-fluorouracil concentrations to potentiate the antitumor activity of continuous venous infusion of 5-fluorouracil.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Circadian Rhythm; Drug Synergism; Fluoroura | 1989 |
[BOF-A1 and BOF-A2, new 5-FU degradation-inhibitory agents].
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Floxuridine; Fluorou | 1987 |
[Comparison of continuous venous infusion of 5-FU and FT-207 under total parenteral nutrition].
Topics: Animals; Fluorouracil; Infusions, Intravenous; Male; Parenteral Nutrition, Total; Rats; Rats, Inbred | 1986 |