tegafur has been researched along with Neutropenia in 120 studies
Neutropenia: A decrease in the number of NEUTROPHILS found in the blood.
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"Gemcitabine (GEM) plus cisplatin (CDDP) chemotherapy has been used worldwide as the standard first-line treatment for advanced biliary tract cancer (BTC)." | 9.24 | A Multicenter Phase II Study of Gemcitabine plus S-1 Chemotherapy for Advanced Biliary Tract Cancer. ( Arima, S; Furuse, J; Kasuga, A; Kawai, K; Kitamura, H; Kobayashi, T; Nagashima, F; Naruge, D; Okamoto, T; Okano, N; Shimizu, K; Sugiyama, M; Suzuki, Y; Takasu, A; Toki, M, 2017) |
"Combination chemotherapy with S-1 and irinotecan is one of the standard treatments for metastatic colorectal cancer (mCRC) in Japan." | 9.22 | S-1 and irinotecan plus bevacizumab as second-line chemotherapy for patients with oxaliplatin-refractory metastatic colorectal cancer: a multicenter phase II study in Japan (KSCC1102). ( Akagi, Y; Baba, H; Emi, Y; Kawanaka, H; Kitazono, M; Maehara, Y; Maekawa, S; Miyamoto, Y; Murakami, H; Natsugoe, S; Ogata, Y; Oki, E; Saeki, H; Shimokawa, M; Tanioka, H; Tsuji, A, 2016) |
"Oral tegafur/uracil and leucovorin (UFT/LV) therapy is effective and safe for elderly patients with advanced or metastatic colorectal cancer (CRC)." | 9.20 | Phase II Study of Oral Tegafur/Uracil and Leucovorin plus Bevacizumab as a First-Line Therapy for Elderly Patients with Advanced or Metastatic Colorectal Cancer. ( Doki, Y; Fukunaga, M; Fukuzaki, T; Hasegawa, J; Hata, T; Ikeda, M; Matsuda, C; Mizushima, T; Mori, M; Murata, K; Nezu, R; Ota, H; Sekimoto, M; Takemasa, I; Tamagawa, H; Tsujie, M; Yamamoto, H, 2015) |
"S-1 and gemcitabine (GS) combination therapy is a promising treatment for advanced biliary tract cancer (BTC)." | 9.20 | Phase I trial of oral S-1 combined with hepatic arterial infusion of gemcitabine in unresectable biliary tract cancer. ( Hayashi, T; Ishiwatari, H; Kato, J; Kobune, M; Miyanishi, K; Ono, M; Sato, T; Sato, Y; Takimoto, R; Yoshida, M, 2015) |
"We investigated the efficacy and safety of metronomic chemotherapy with combined irinotecan and tegafur-gimeracil-oteracil potassium (TS-1) in patients with metastatic and recurrent breast cancer (MRBC), and the association between irinotecan metabolizing enzyme UDP-glucuronosyltransferase 1A1 (UGT1A1) gene polymorphisms and adverse events." | 9.20 | Phase II clinical trial of metronomic chemotherapy with combined irinotecan and tegafur-gimeracil-oteracil potassium in metastatic and recurrent breast cancer. ( Fujii, T; Iwakuma, N; Kakuma, T; Mishima, M; Otsuka, H; Shirouzu, K; Takahashi, R; Takenaka, M; Tanaka, M; Toh, U, 2015) |
"To investigate the efficacy of gemcitabine plus uracil-tegafur (UFT) combination chemotherapy as a salvage treatment in patients with metastatic colorectal cancer (MCRC)." | 9.19 | Phase II trial of gemcitabine plus UFT as salvage treatment in oxaliplatin, irinotecan and fluoropyrimidine-refractory metastatic colorectal cancer. ( Bang, YJ; Choi, IS; Han, SW; Im, SA; Kim, JH; Kim, TY; Kim, YJ; Lee, KH; Lee, KW; Oh, DY, 2014) |
"In Japan, a study comparing the effectiveness and safety of irinotecan plus S-1 (IRIS) with those of a combination of 5-fluorouracil, leucovorin, and irinotecan (FOLFIRI) as second-line treatment in patients with advanced or recurrent colorectal cancer demonstrated that IRIS was non-inferior to FOLFIRI." | 9.16 | Phase II study of combined chemotherapy with irinotecan and S-1 (IRIS) plus bevacizumab in patients with inoperable recurrent or advanced colorectal cancer. ( Fukushima, H; Hatanaka, K; Iwanaga, I; Kobayashi, Y; Komatsu, Y; Kudo, M; Meguro, T; Miyagishima, T; Munakata, M; Nakamura, M; Nakatsumi, H; Sakata, Y; Sogabe, S; Tateyama, M; Yuki, S, 2012) |
"We evaluated the efficacy and safety of a combination of S-1 and cisplatin (SP) versus gemcitabine and cisplatin (GP) as first-line therapy for advanced biliary tract adenocarcinoma (ABTA)." | 9.16 | Randomized phase II trial of S-1 and cisplatin versus gemcitabine and cisplatin in patients with advanced biliary tract adenocarcinoma. ( Ahn, S; Kang, MJ; Kim, MH; Kim, TW; Lee, JL; Lee, SK; Lee, SS; Park, DH; Seo, DW, 2012) |
"This phase II study was designed to evaluate the efficacy and safety of oral fluoropyrimidine S-1 plus irinotecan (IRIS regimen) in patients with previously untreated metastatic colorectal cancer." | 9.15 | Phase II study of combined treatment with irinotecan and S-1 (IRIS) in patients with inoperable or recurrent advanced colorectal cancer (HGCSG0302). ( Asaka, M; Fukushima, H; Iwanaga, I; Komatsu, Y; Kudo, M; Meguro, T; Saga, A; Sakata, Y; Sogabe, S; Tateyama, M; Uebayashi, M; Yuki, S, 2011) |
"Gemcitabine and S-1 combination chemotherapy has promising efficacy and good tolerability in patients with advanced biliary tract cancer." | 9.14 | Multicenter, phase II study of gemcitabine and S-1 combination chemotherapy in patients with advanced biliary tract cancer. ( Hasebe, O; Hirano, K; Isayama, H; Ito, Y; Kogure, H; Maetani, I; Nakai, Y; Omata, M; Sasahira, N; Sasaki, T; Tada, M; Toda, N; Togawa, O; Tsujino, T; Yasuda, I, 2010) |
"This article describes the design and early results of an open-label, nonrandomized phase I/II trial of oral UFT plus leucovorin therapy in combination with bolus injections of epirubicin and cyclophosphamide in patients with advanced or metastatic breast cancer." | 9.09 | UFT/leucovorin plus bolus epirubicin and cyclophosphamide in advanced/metastatic breast cancer. ( Gregory, RK; Johnston, SR; Miles, D; Smith, IE, 2000) |
"The aim of this study was to evaluate systematically the efficacy and safety of oral uracil-tegafur (UFT) plus leucovorin (LV) compared with infusional fluorouracil (5-FU) plus LV for advanced colorectal cancer." | 8.87 | Oral uracil-tegafur plus leucovorin vs fluorouracil bolus plus leucovorin for advanced colorectal cancer: a meta-analysis of five randomized controlled trials. ( Bin, Q; Cao, Y; Gao, F; Li, J; Liao, C, 2011) |
"Gemcitabine has been standard of care in advanced pancreatic adenocarcinomas (PC) for almost two decades." | 7.88 | S-1 (Teysuno) and gemcitabine in Caucasian patients with unresectable pancreatic adenocarcinoma. ( Bjerregaard, JK; Ejlsmark, MW; Jensen, HA; Krogh, M; Pfeiffer, P; Schonnemann, KR; Winther, SB, 2018) |
"We experienced a case of good response in acute respiratory distress syndrome (ARDS) treated with sivelestat sodium hydrate during chemotherapy for cholangiocarcinoma." | 7.74 | [Good response in ARDS treated with sivelestat sodium hydrate during chemotherapy for cholangiocarcinoma]. ( Hanada, N; Hori, K; Kusano, S; Momi, H, 2007) |
"Grade 3 neutropenia was common (35%)." | 6.90 | A single-arm, phase II trial of neoadjuvant gemcitabine and S1 in patients with resectable and borderline resectable pancreatic adenocarcinoma: PREP-01 study. ( Honda, G; Matsumoto, I; Motoi, F; Satoi, S; Shinchi, H; Sho, M; Tsuchida, A; Unno, M; Wada, K, 2019) |
"Although standard chemotherapy for esophageal cancer patients is fluorouracil and cisplatin, the prognosis is still unsatisfactory." | 6.82 | Phase II trial of neoadjuvant chemotherapy with docetaxel, nedaplatin, and S1 for advanced esophageal squamous cell carcinoma. ( Matsuhashi, N; Okumura, N; Tanahashi, T; Tanaka, Y; Yamaguchi, K; Yoshida, K, 2016) |
" Based on the results of our previous phase I/II study in patients with gastric cancer, the dosage was established in consideration of safety for outpatient therapy." | 6.72 | [Irinotecan plus oral S-1 in patients with advanced colorectal cancer--biweekly IRIS regimen]. ( Asaka, M; Komatsu, Y; Kudo, M; Tateyama, M; Yuki, S, 2006) |
"Gemcitabine (GEM) plus cisplatin (CDDP) chemotherapy has been used worldwide as the standard first-line treatment for advanced biliary tract cancer (BTC)." | 5.24 | A Multicenter Phase II Study of Gemcitabine plus S-1 Chemotherapy for Advanced Biliary Tract Cancer. ( Arima, S; Furuse, J; Kasuga, A; Kawai, K; Kitamura, H; Kobayashi, T; Nagashima, F; Naruge, D; Okamoto, T; Okano, N; Shimizu, K; Sugiyama, M; Suzuki, Y; Takasu, A; Toki, M, 2017) |
"Combination chemotherapy with S-1 and irinotecan is one of the standard treatments for metastatic colorectal cancer (mCRC) in Japan." | 5.22 | S-1 and irinotecan plus bevacizumab as second-line chemotherapy for patients with oxaliplatin-refractory metastatic colorectal cancer: a multicenter phase II study in Japan (KSCC1102). ( Akagi, Y; Baba, H; Emi, Y; Kawanaka, H; Kitazono, M; Maehara, Y; Maekawa, S; Miyamoto, Y; Murakami, H; Natsugoe, S; Ogata, Y; Oki, E; Saeki, H; Shimokawa, M; Tanioka, H; Tsuji, A, 2016) |
"We investigated the efficacy and safety of metronomic chemotherapy with combined irinotecan and tegafur-gimeracil-oteracil potassium (TS-1) in patients with metastatic and recurrent breast cancer (MRBC), and the association between irinotecan metabolizing enzyme UDP-glucuronosyltransferase 1A1 (UGT1A1) gene polymorphisms and adverse events." | 5.20 | Phase II clinical trial of metronomic chemotherapy with combined irinotecan and tegafur-gimeracil-oteracil potassium in metastatic and recurrent breast cancer. ( Fujii, T; Iwakuma, N; Kakuma, T; Mishima, M; Otsuka, H; Shirouzu, K; Takahashi, R; Takenaka, M; Tanaka, M; Toh, U, 2015) |
"S-1 and gemcitabine (GS) combination therapy is a promising treatment for advanced biliary tract cancer (BTC)." | 5.20 | Phase I trial of oral S-1 combined with hepatic arterial infusion of gemcitabine in unresectable biliary tract cancer. ( Hayashi, T; Ishiwatari, H; Kato, J; Kobune, M; Miyanishi, K; Ono, M; Sato, T; Sato, Y; Takimoto, R; Yoshida, M, 2015) |
"Oral tegafur/uracil and leucovorin (UFT/LV) therapy is effective and safe for elderly patients with advanced or metastatic colorectal cancer (CRC)." | 5.20 | Phase II Study of Oral Tegafur/Uracil and Leucovorin plus Bevacizumab as a First-Line Therapy for Elderly Patients with Advanced or Metastatic Colorectal Cancer. ( Doki, Y; Fukunaga, M; Fukuzaki, T; Hasegawa, J; Hata, T; Ikeda, M; Matsuda, C; Mizushima, T; Mori, M; Murata, K; Nezu, R; Ota, H; Sekimoto, M; Takemasa, I; Tamagawa, H; Tsujie, M; Yamamoto, H, 2015) |
"To investigate the efficacy of gemcitabine plus uracil-tegafur (UFT) combination chemotherapy as a salvage treatment in patients with metastatic colorectal cancer (MCRC)." | 5.19 | Phase II trial of gemcitabine plus UFT as salvage treatment in oxaliplatin, irinotecan and fluoropyrimidine-refractory metastatic colorectal cancer. ( Bang, YJ; Choi, IS; Han, SW; Im, SA; Kim, JH; Kim, TY; Kim, YJ; Lee, KH; Lee, KW; Oh, DY, 2014) |
"We conducted a phase I study of S-1 combined with irinotecan and oxaliplatin (TIROX) to determine the maximum-tolerated dose (MTD) and recommended dose (RD) and to assess its safety, pharmacokinetics, pharmacogenetics, and preliminary efficacy in patients with metastatic colorectal cancer (MCRC) or metastatic gastric cancer (MGC)." | 5.17 | Phase I clinical and pharmacokinetic/pharmacogenetic study of a triplet regimen of S-1/irinotecan/oxaliplatin in patients with metastatic colorectal or gastric cancer. ( Hong, YS; Jung, KH; Kim, SY; Kong, SY; Lim, HS; Park, SR; Park, YI; Seong, MW, 2013) |
"In Japan, a study comparing the effectiveness and safety of irinotecan plus S-1 (IRIS) with those of a combination of 5-fluorouracil, leucovorin, and irinotecan (FOLFIRI) as second-line treatment in patients with advanced or recurrent colorectal cancer demonstrated that IRIS was non-inferior to FOLFIRI." | 5.16 | Phase II study of combined chemotherapy with irinotecan and S-1 (IRIS) plus bevacizumab in patients with inoperable recurrent or advanced colorectal cancer. ( Fukushima, H; Hatanaka, K; Iwanaga, I; Kobayashi, Y; Komatsu, Y; Kudo, M; Meguro, T; Miyagishima, T; Munakata, M; Nakamura, M; Nakatsumi, H; Sakata, Y; Sogabe, S; Tateyama, M; Yuki, S, 2012) |
"We evaluated the efficacy and safety of a combination of S-1 and cisplatin (SP) versus gemcitabine and cisplatin (GP) as first-line therapy for advanced biliary tract adenocarcinoma (ABTA)." | 5.16 | Randomized phase II trial of S-1 and cisplatin versus gemcitabine and cisplatin in patients with advanced biliary tract adenocarcinoma. ( Ahn, S; Kang, MJ; Kim, MH; Kim, TW; Lee, JL; Lee, SK; Lee, SS; Park, DH; Seo, DW, 2012) |
"This phase II study was designed to evaluate the efficacy and safety of oral fluoropyrimidine S-1 plus irinotecan (IRIS regimen) in patients with previously untreated metastatic colorectal cancer." | 5.15 | Phase II study of combined treatment with irinotecan and S-1 (IRIS) in patients with inoperable or recurrent advanced colorectal cancer (HGCSG0302). ( Asaka, M; Fukushima, H; Iwanaga, I; Komatsu, Y; Kudo, M; Meguro, T; Saga, A; Sakata, Y; Sogabe, S; Tateyama, M; Uebayashi, M; Yuki, S, 2011) |
"Patients were eligible for the study if they had histologically documented gastric adenocarcinoma previously treated with paclitaxel and cisplatin, age > or = 18 years, Eastern Clinical Oncology Group performance status < or =2, adequate organ function, and no evidence of gastrointestinal obstruction or passage disturbance." | 5.14 | Phase II study of S-1 monotherapy in paclitaxel- and cisplatin-refractory gastric cancer. ( Bae, WK; Cho, SH; Chung, IJ; Hwang, JE; Lee, SJ; Shim, HJ; Yoon, JY, 2009) |
"Gemcitabine and S-1 combination chemotherapy has promising efficacy and good tolerability in patients with advanced biliary tract cancer." | 5.14 | Multicenter, phase II study of gemcitabine and S-1 combination chemotherapy in patients with advanced biliary tract cancer. ( Hasebe, O; Hirano, K; Isayama, H; Ito, Y; Kogure, H; Maetani, I; Nakai, Y; Omata, M; Sasahira, N; Sasaki, T; Tada, M; Toda, N; Togawa, O; Tsujino, T; Yasuda, I, 2010) |
"This article describes the design and early results of an open-label, nonrandomized phase I/II trial of oral UFT plus leucovorin therapy in combination with bolus injections of epirubicin and cyclophosphamide in patients with advanced or metastatic breast cancer." | 5.09 | UFT/leucovorin plus bolus epirubicin and cyclophosphamide in advanced/metastatic breast cancer. ( Gregory, RK; Johnston, SR; Miles, D; Smith, IE, 2000) |
"The aim of this study was to evaluate systematically the efficacy and safety of oral uracil-tegafur (UFT) plus leucovorin (LV) compared with infusional fluorouracil (5-FU) plus LV for advanced colorectal cancer." | 4.87 | Oral uracil-tegafur plus leucovorin vs fluorouracil bolus plus leucovorin for advanced colorectal cancer: a meta-analysis of five randomized controlled trials. ( Bin, Q; Cao, Y; Gao, F; Li, J; Liao, C, 2011) |
"A combination therapy of irinotecan hydrochloride (CPT-11) with continuous intravenous infusions of (infusional) 5-fluorouracil (5-FU) and Leucovorin (LV) is often used to treat advanced colorectal cancer." | 4.83 | [The current evidence of S-1 and irinotecan hydrochloride combination chemotherapy with tri-weekly schedule]. ( Goto, A, 2006) |
"Gemcitabine has been standard of care in advanced pancreatic adenocarcinomas (PC) for almost two decades." | 3.88 | S-1 (Teysuno) and gemcitabine in Caucasian patients with unresectable pancreatic adenocarcinoma. ( Bjerregaard, JK; Ejlsmark, MW; Jensen, HA; Krogh, M; Pfeiffer, P; Schonnemann, KR; Winther, SB, 2018) |
"We experienced a case of good response in acute respiratory distress syndrome (ARDS) treated with sivelestat sodium hydrate during chemotherapy for cholangiocarcinoma." | 3.74 | [Good response in ARDS treated with sivelestat sodium hydrate during chemotherapy for cholangiocarcinoma]. ( Hanada, N; Hori, K; Kusano, S; Momi, H, 2007) |
"Twenty-four patients with metastatic breast cancer that had progressed after high-dose chemotherapy with peripheral blood progenitor cell (PBPC) support were given intramuscular methotrexate in combination with oral UFT (tegafur and uracil) and oral leucovorin (the MUL regimen)." | 3.69 | Preliminary results. UFT/methotrexate/leucovorin for breast Ca patients in progression after HDCT/PBPC support. ( Ayala, F; Casado, A; Diaz-Rubio, E; López-Martin, JA; Martin, M; Nieto, Y; Rodriguez-Lescure, A, 1997) |
"Twenty-five adult patients with adenocarcinoma of unknown primary origin were treated with oral tegafur followed by the combination of cyclophosphamide/adriamycin/cis-diamminedichloroplatinum(II) (CAP) if they failed to respond to tegafur." | 3.66 | Sequential chemotherapy for adenocarcinoma of unknown primary. ( Bedikian, AY; Bodey, GP; Burgess, MA; Valdivieso, M, 1983) |
"Patients with stage III gastric cancer who underwent D2 gastrectomy were enrolled." | 3.01 | Phase II feasibility study of adjuvant chemotherapy with docetaxel/cisplatin/S-1 followed by S-1 for stage III gastric cancer. ( Hirahara, N; Hyakudomi, R; Ishitobi, K; Kaji, S; Matsubara, T; Tajima, Y; Takai, K; Uchida, Y; Yamamoto, T, 2021) |
"Grade 3 neutropenia was common (35%)." | 2.90 | A single-arm, phase II trial of neoadjuvant gemcitabine and S1 in patients with resectable and borderline resectable pancreatic adenocarcinoma: PREP-01 study. ( Honda, G; Matsumoto, I; Motoi, F; Satoi, S; Shinchi, H; Sho, M; Tsuchida, A; Unno, M; Wada, K, 2019) |
"Previous studies have shown sex-related differences in the incidence of adverse events following treatment with fluoropyrimidines, however the mechanism of this difference is unknown." | 2.90 | Sex differences in the safety of S-1 plus oxaliplatin and S-1 plus cisplatin for patients with metastatic gastric cancer. ( Amagai, K; Chin, K; Fujii, H; Fuse, N; Gotoh, M; Hironaka, S; Hyodo, I; Imamura, H; Koizumi, W; Nishikawa, K; Nishina, T; Niwa, Y; Shimada, K; Sugimoto, N; Tsuda, M; Tsuji, A; Yamada, Y; Yamaguchi, K; Yasui, H, 2019) |
"Although standard chemotherapy for esophageal cancer patients is fluorouracil and cisplatin, the prognosis is still unsatisfactory." | 2.82 | Phase II trial of neoadjuvant chemotherapy with docetaxel, nedaplatin, and S1 for advanced esophageal squamous cell carcinoma. ( Matsuhashi, N; Okumura, N; Tanahashi, T; Tanaka, Y; Yamaguchi, K; Yoshida, K, 2016) |
"This phase I trial of preoperative S-1 in combination with oxaliplatin and radiation for lower rectal cancer with T4 and lateral pelvic lymph node metastasis revealed that the recommended dose of oxaliplatin was 60 mg/m(2) weekly." | 2.80 | A phase I trial of preoperative S-1 in combination with oxaliplatin and pelvic radiation for lower rectal cancer with T4 and lateral pelvic lymph node metastasis. ( Fujita, S; Hamaguchi, T; Ito, Y; Kinugasa, Y; Moriya, Y; Noura, S; Ohue, M; Saito, N; Sakai, D; Shimada, Y, 2015) |
"The prognosis for locally advanced gastric cancer is poor despite advances in adjuvant chemotherapy." | 2.79 | Sequential paclitaxel followed by tegafur and uracil (UFT) or S-1 versus UFT or S-1 monotherapy as adjuvant chemotherapy for T4a/b gastric cancer (SAMIT): a phase 3 factorial randomised controlled trial. ( Buyse, M; Fukushima, R; Hara, A; Imamura, H; Kobayashi, M; Kojima, H; Miyashita, Y; Morita, S; Nishikawa, K; Nozaki, I; Oba, K; Sakamoto, J; Takahashi, M; Takahashi, N; Takiguchi, N; Tanabe, K; Tatsumoto, N; Tsuburaya, A; Yoshida, K; Yoshino, S, 2014) |
"Patients with gastric cancer with bulky lymph node metastasis along the coeliac artery and its branches and/or PAN metastasis received two or three 28-day cycles of S-1 plus cisplatin, followed by gastrectomy with D2 plus PAN dissection." | 2.79 | Neoadjuvant chemotherapy with S-1 and cisplatin followed by D2 gastrectomy with para-aortic lymph node dissection for gastric cancer with extensive lymph node metastasis. ( Fukushima, N; Mizusawa, J; Nashimoto, A; Sasako, M; Tanaka, Y; Tsuburaya, A, 2014) |
"Paclitaxel was administered intravenously on day 1 at a dose of 120 mg/m(2), and oral S-1 was administered twice a day from days 1 to 7, followed by a 7-day drug-free interval." | 2.79 | Biweekly S-1 plus paclitaxel (SPA) as second-line chemotherapy after failure from fluoropyrimidine and platinum in advanced gastric cancer: a phase II study. ( Fang, W; Jiang, H; Mao, C; Qian, J; Xu, N; Zhang, X; Zhao, P; Zheng, Y, 2014) |
"Cediranib 20 mg/day in combination with cisplatin and S-1 or capecitabine was tolerable, with no new toxicities identified, and showed preliminary evidence of antitumour activity." | 2.77 | Phase I study of cediranib in combination with cisplatin plus fluoropyrimidine (S-1 or capecitabine) in Japanese patients with previously untreated advanced gastric cancer. ( Boku, N; Brown, KH; Hayashi, H; Muro, K; Nakajima, TE; Satoh, T; Shi, X; Shimada, Y; Takahari, D; Taku, K; Yamada, Y, 2012) |
"Gemcitabine was administered at a dose of 1000 mg/m(2) over 30 min on days 1 and 8, and oral S-1 at a dose of 40 mg/m(2) twice daily from days 1 to 14, repeated every 3 weeks." | 2.76 | Multicenter phase II study of gemcitabine and S-1 combination therapy (GS Therapy) in patients with metastatic pancreatic cancer. ( Boku, N; Funakoshi, A; Furuse, J; Moriyasu, F; Nakamori, S; Ohkawa, S; Okusaka, T; Sato, T; Tanaka, K; Ueno, H; Yamao, K; Yokosuka, O, 2011) |
"Diarrhea was the most common type of nonhematologic toxicity: 3 patients had Grade 3 diarrhea." | 2.76 | A Phase II trial of neoadjuvant preoperative chemoradiotherapy with S-1 plus irinotecan and radiation in patients with locally advanced rectal cancer: clinical feasibility and response rate. ( Hatate, K; Hayakawa, K; Ihara, A; Koizumi, W; Naito, M; Nakamura, T; Okayasu, I; Onosato, W; Ozawa, H; Sato, T; Watanabe, M; Yamashita, K, 2011) |
"Paclitaxel (160 mg/m²) was administered by infusion for 3 h on the first day." | 2.76 | A phase II multi-center study of triple therapy with paclitaxel, S-1 and cisplatin in patients with advanced gastric cancer. ( Goto, H; Haruta, J; Ina, K; Iwase, H; Kumada, T; Shimada, M; Shinoda, M; Sugihara, M; Tsuzuki, T, 2011) |
" Pharmacokinetic analyses were performed following a single dose of S-1 on D-5 and D1 of the first cycle." | 2.75 | Phase I/II and pharmacokinetic study of S-1 and oxaliplatin in previously untreated advanced gastric cancer. ( Bae, KS; Chang, HM; Jang, G; Kang, YK; Kim, TW; Lee, JL; Lee, SS; Park, I; Ryu, MH; Sym, SJ; Yoo, C, 2010) |
"Etoposide 50 mg/m(2), UFT 250 mg/m(2) and leucovorin 90 mg (fixed dose) were dosed in 3 gifts approximately 8h apart for 14 days followed by 1 week rest every 3 weeks until progressive disease (PD)." | 2.74 | Oral UFT, etoposide and leucovorin in recurrent non-small cell lung cancer: a non-randomized phase II study. ( Aerts, JG; Gras, J; Hoogsteden, H; Pouw, E; Pronk, T; Salomé, J; Schmitz, PI; Surmont, V; Tan, KY; van Klaveren, RJ; Vernhout, R, 2009) |
"Optimal chemotherapy for advanced biliary tract cancer (BTC) is yet to be defined." | 2.73 | A phase II trial of S-1 and cisplatin in patients with metastatic or relapsed biliary tract cancer. ( Bang, YJ; Choi, IS; Heo, DS; Im, SA; Kim, DW; Kim, HG; Kim, JH; Kim, SW; Kim, TY; Kim, YJ; Lee, KW; Lee, SH; Oh, DY; Oh, SY; Yoon, YB, 2008) |
"He died of brain metastases." | 2.72 | [A case of adenocarcinoma of the lung significantly responding to TS-1 plus cisplatin combination chemotherapy]. ( Asou, H; Ichinose, Y; Maruyama, R; Okamoto, T; Suemitsu, R; Wataya, H, 2006) |
" Based on the results of our previous phase I/II study in patients with gastric cancer, the dosage was established in consideration of safety for outpatient therapy." | 2.72 | [Irinotecan plus oral S-1 in patients with advanced colorectal cancer--biweekly IRIS regimen]. ( Asaka, M; Komatsu, Y; Kudo, M; Tateyama, M; Yuki, S, 2006) |
"Grade 4 neutropenia was observed in one of the 59 patients (1." | 2.72 | [Phase II study of S-1, a novel oral fluorouracil, in advanced non-small-cell lung cancer]. ( Kawahara, M; Yumine, K, 2006) |
"Paclitaxel was administered by intravenous drip infusion at a starting dose (level 1) of 50 mg/m2 on days 1, 8, and 15." | 2.72 | [A phase I study of combination chemotherapy using TS-1 and weekly paclitaxel for advanced gastric cancer]. ( Doki, Y; Fujita, J; Fujiwara, Y; Kan, K; Miyata, H; Monden, M; Takiguchi, S; Tsukahara, K; Yasuda, T, 2006) |
"Irinotecan was given intravenously over the course of 90 min on day 1 and S-1 was given orally from days 1 to 14 of a 21-day cycle." | 2.71 | Phase I study of irinotecan and S-1 combination therapy in patients with metastatic gastric cancer. ( Arai, T; Goto, A; Hamaguchi, T; Muro, K; Shimada, Y; Shirao, K; Ura, T; Yamada, Y; Yasui, H, 2003) |
" Administration of more than 2 courses was attempted for each patient, with the same dosage levels at all 3 scheduled steps." | 2.71 | [Phase I study of gemcitabine (GEM) and UFT combination chemotherapy for unresectable/recurrent pancreatic cancer]. ( Dono, K; Maruhashi, S; Miyamoto, A; Monden, M; Nagano, H; Nakamori, S; Sakon, M; Takahashi, Y; Tujie, M; Umeshita, K, 2004) |
"Grade 4 neutropenia was observed in one of the 59 patients (1." | 2.70 | Phase II study of S-1, a novel oral fluorouracil, in advanced non-small-cell lung cancer. ( Furuse, K; Hasegawa, K; Kawahara, M; Kudoh, S; Matsui, K; Niitani, H; Segawa, Y; Yoshimori, K, 2001) |
" The potential benefit of long bioavailability and oral delivery of UFT compares favorably with continuous infusion regimens without the added morbidity of a catheter and pump." | 2.69 | A phase I study of combined UFT plus leucovorin and radiotherapy for pancreatic cancer. ( Bonner, JA; Childs, HA; Newsome, J; Raben, D; Robert, F; Spencer, SA, 2000) |
"Oral tegafur and I." | 2.65 | A comparative study of oral tegafur and intravenous 5-fluorouracil in patients with metastatic colorectal cancer. ( Bedikian, AY; Bodey, GP; Karlin, D; Korinek, J; Stroehlein, J, 1983) |
"Chemotherapy for colorectal cancer is now improving rapidly due to new drugs like oxaliplatin and molecular targeting drugs." | 2.43 | [S-1 as a single agent for colorectal cancer]. ( Eguchi, T; Shirao, K, 2006) |
"Patients with advanced gastric cancer and severe peritoneal metastasis were included if they had massive ascites and/or inadequate oral intake requiring intravenous nutritional support." | 1.51 | Fluoropyrimidine with or without platinum as first-line chemotherapy in patients with advanced gastric cancer and severe peritoneal metastasis: a multicenter retrospective study. ( Arai, H; Boku, N; Fukuda, N; Hironaka, S; Iwasa, S; Kawahira, M; Masuishi, T; Minashi, K; Muro, K; Nakajima, TE; Takahari, D; Yasui, H, 2019) |
"However, severe neutropenia is often observed (40%) during this therapy." | 1.48 | Risk factors for severe neutropenia induced by combination therapy of S-1 and cisplatin in patients with advanced/recurrent gastric cancer. ( Kawachi, S; Kimura, M; Shinoda, Y; Usami, E; Yoshimura, T, 2018) |
"Gemcitabine plus S-1 is a viable treatment alternative to gemcitabine, which is one of the standard treatments in patients with LAPC." | 1.46 | Efficacy and safety of gemcitabine plus S-1 in pancreatic cancer: a pooled analysis of individual patient data. ( Furuse, J; Hamada, C; Ikari, T; Imai, S; Isayama, H; Ishii, H; Nakai, Y; Okamura, S; Okusaka, T, 2017) |
"The chemotherapy regime was 80 mg/m(2) liposome-paclitaxel given on days 1, 8, 15 and 22, combined with S-1 60 mg (body surface area > 1." | 1.40 | Effect of the weekly administration of liposome-Paclitaxel combined with s-1 on advanced gastric cancer. ( Chen, L; Chen, Q; Chen, Z; Shen, L; Shen, X; Tao, J; Wang, H; Wang, J; Zhang, Y; Zhu, M; Zhuang, Z, 2014) |
" The most common adverse events were neutropenia (n = 49, 69." | 1.38 | [A safety analysis in patients treated with oxaliplatin plus S-1 as adjuvant therapy for gastric cancer]. ( Chi, Y; Huang, J; Lü, X; Qu, T; Wang, JW; Yang, L; Zhou, Y, 2012) |
"The regimen of nedaplatin combined with tegafur is effective and tolerable for the treatment of advanced esophageal cancer." | 1.35 | [Nedaplatin combined with tegafur in the treatment for advanced esophageal cancer]. ( Chen, XB; Fan, QX; Geng, L; Han, JW; Jiao, ZM; Lu, P; Lu, SP; Lu, TY; Luo, SX; Ma, ZY; Song, M; Wang, GJ; Wang, JS; Wang, R; Wang, RL; Wu, XA; Zhang, MZ; Zhao, YF, 2008) |
" Thus, TS-1 and CPT-11 combination therapy has been effective for 17 months, suggesting that it is promising for long-term administration and survival to continue it perseveringly." | 1.33 | [A case of non-curatively resected gastric cancer successfully treated over 17 months with TS-1 and irinotecan combination therapy]. ( Kawamura, S; Okumura, S; Shimada, E; Sumi, Y; Tei, M; Yamagishi, D, 2006) |
"Grade 3 neutropenia was observed, but no other severe toxicities were noted." | 1.33 | [Chemotherapy-naïve advanced pancreatic cancer with multiple liver metastases successfully treated by S-1 monotherapy--a case report]. ( Boku, N; Fukutomi, A; Yoshino, T, 2006) |
"As a measure to ensure safe use of TS-1 during the early marketing period, a drug use investigation was conducted on an all-case basis." | 1.33 | [Example of safety measures for antineoplastic agents immediately after market launch--a case of TS-1 capsule all example use result investigation that executes safety monitoring--]. ( Ito, K, 2006) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 2 (1.67) | 18.7374 |
1990's | 5 (4.17) | 18.2507 |
2000's | 45 (37.50) | 29.6817 |
2010's | 65 (54.17) | 24.3611 |
2020's | 3 (2.50) | 2.80 |
Authors | Studies |
---|---|
Hirahara, N | 1 |
Matsubara, T | 1 |
Kaji, S | 2 |
Yamamoto, T | 1 |
Hyakudomi, R | 1 |
Takai, K | 1 |
Ishitobi, K | 1 |
Uchida, Y | 1 |
Tajima, Y | 1 |
Kasai, T | 2 |
Mori, K | 1 |
Kishi, K | 1 |
Kaburagi, T | 1 |
Hosomi, Y | 1 |
Imai, H | 2 |
Yamada, Y | 4 |
Yomota, M | 1 |
Moriguchi, S | 1 |
Seike, M | 1 |
Minato, K | 1 |
Gemma, A | 3 |
Tsuchiya, T | 1 |
Kamohara, R | 1 |
Muraoka, M | 1 |
Nagayasu, T | 1 |
Saeki, S | 1 |
Takenoyama, M | 1 |
Suzuki, M | 2 |
Inada, K | 1 |
Tokunaga, S | 1 |
Hayashi, T | 2 |
Urabe, S | 1 |
Koga, T | 1 |
Akamine, S | 1 |
Sugio, K | 1 |
Fang, M | 1 |
Song, T | 1 |
Liang, X | 1 |
Lv, S | 1 |
Li, J | 3 |
Xu, H | 1 |
Luo, L | 1 |
Jia, Y | 1 |
Hamada, C | 1 |
Okusaka, T | 3 |
Ikari, T | 1 |
Isayama, H | 3 |
Furuse, J | 4 |
Ishii, H | 2 |
Nakai, Y | 3 |
Imai, S | 2 |
Okamura, S | 1 |
Wang, F | 1 |
Fan, QX | 2 |
Wang, HH | 1 |
Han, DM | 1 |
Song, NS | 1 |
Lu, H | 1 |
Xu, R | 1 |
Xu, J | 1 |
Denda, T | 1 |
Ikejiri, K | 1 |
Shen, L | 2 |
Toh, Y | 1 |
Shimada, K | 4 |
Kato, T | 1 |
Sakai, K | 1 |
Yamamoto, M | 1 |
Mishima, H | 1 |
Wang, J | 2 |
Baba, H | 4 |
Winther, SB | 1 |
Bjerregaard, JK | 1 |
Schonnemann, KR | 1 |
Ejlsmark, MW | 1 |
Krogh, M | 1 |
Jensen, HA | 1 |
Pfeiffer, P | 1 |
Kawachi, S | 1 |
Shinoda, Y | 1 |
Kimura, M | 3 |
Usami, E | 1 |
Yoshimura, T | 1 |
Nakachi, K | 1 |
Konishi, M | 1 |
Ikeda, M | 2 |
Saiura, A | 1 |
Sugiyama, M | 2 |
Sakamoto, H | 1 |
Shimamura, T | 1 |
Ohta, T | 1 |
Motoi, F | 1 |
Satoi, S | 1 |
Honda, G | 2 |
Wada, K | 1 |
Shinchi, H | 1 |
Matsumoto, I | 1 |
Sho, M | 1 |
Tsuchida, A | 1 |
Unno, M | 1 |
Kashiwabara, K | 1 |
Semba, H | 1 |
Fujii, S | 2 |
Tsumura, S | 1 |
Shigeyoshi, I | 1 |
Misawa, K | 1 |
Ito, S | 1 |
Ito, Y | 3 |
Komori, K | 1 |
Abe, T | 1 |
Senda, Y | 1 |
Kinoshita, T | 1 |
Uemura, N | 1 |
Natsume, S | 1 |
Oshiro, T | 1 |
Higaki, E | 1 |
Shimizu, Y | 2 |
Sugawara, S | 2 |
Nakagawa, K | 2 |
Yamamoto, N | 2 |
Nokihara, H | 1 |
Ohe, Y | 1 |
Nishio, M | 1 |
Takahashi, T | 1 |
Goto, K | 1 |
Maemondo, M | 2 |
Ichinose, Y | 4 |
Seto, T | 2 |
Sakai, H | 1 |
Imamura, F | 1 |
Shingyoji, M | 1 |
Saka, H | 2 |
Inoue, A | 2 |
Takeda, K | 2 |
Okamoto, I | 2 |
Kiura, K | 1 |
Morita, S | 5 |
Tamura, T | 1 |
Koizumi, W | 4 |
Nishikawa, K | 2 |
Gotoh, M | 2 |
Fuse, N | 1 |
Sugimoto, N | 2 |
Nishina, T | 2 |
Amagai, K | 1 |
Chin, K | 1 |
Niwa, Y | 1 |
Tsuji, A | 5 |
Imamura, H | 4 |
Tsuda, M | 1 |
Yasui, H | 4 |
Fujii, H | 1 |
Yamaguchi, K | 5 |
Hironaka, S | 3 |
Hyodo, I | 2 |
Arai, H | 1 |
Iwasa, S | 1 |
Boku, N | 5 |
Kawahira, M | 1 |
Masuishi, T | 1 |
Muro, K | 3 |
Minashi, K | 1 |
Fukuda, N | 1 |
Takahari, D | 2 |
Nakajima, TE | 3 |
Tachihara, M | 1 |
Ishimoto, O | 1 |
Sakakibara, T | 1 |
Usui, K | 1 |
Watanabe, H | 1 |
Matsubara, N | 2 |
Watanabe, K | 1 |
Kanazawa, K | 1 |
Ishida, T | 1 |
Saijo, Y | 1 |
Nukiwa, T | 1 |
Iwase, H | 2 |
Shimada, M | 2 |
Tsuzuki, T | 2 |
Hirashima, N | 1 |
Okeya, M | 1 |
Hibino, Y | 1 |
Ryuge, N | 1 |
Yokoi, M | 1 |
Kida, Y | 1 |
Kuno, T | 1 |
Tanaka, Y | 3 |
Kato, B | 1 |
Esaki, M | 1 |
Urata, N | 1 |
Kato, E | 1 |
Otsuka, H | 1 |
Fujii, T | 1 |
Toh, U | 1 |
Iwakuma, N | 1 |
Takahashi, R | 1 |
Mishima, M | 1 |
Takenaka, M | 1 |
Kakuma, T | 1 |
Tanaka, M | 2 |
Shirouzu, K | 1 |
Park, SR | 1 |
Hong, YS | 2 |
Lim, HS | 1 |
Seong, MW | 1 |
Kong, SY | 1 |
Kim, SY | 1 |
Park, YI | 1 |
Jung, KH | 1 |
Takahara, N | 1 |
Sasaki, T | 6 |
Hamada, T | 2 |
Uchino, R | 1 |
Mizuno, S | 1 |
Miyabayashi, K | 1 |
Kogure, H | 2 |
Sasahira, N | 2 |
Hirano, K | 2 |
Ijichi, H | 1 |
Tateishi, K | 1 |
Tada, M | 2 |
Koike, K | 1 |
Sunaga, T | 1 |
Suzuki, S | 1 |
Kogo, M | 1 |
Kurihara, T | 1 |
Koike, N | 1 |
Harada, N | 1 |
Kiuchi, Y | 1 |
Kaira, K | 3 |
Tomizawa, Y | 2 |
Yoshino, R | 1 |
Yoshii, A | 1 |
Matsuura, M | 1 |
Iwasaki, Y | 2 |
Koga, Y | 1 |
Ono, A | 1 |
Nishioka, M | 1 |
Kamide, Y | 1 |
Hisada, T | 3 |
Ishizuka, T | 3 |
Shirai, K | 1 |
Ebara, T | 1 |
Saitoh, J | 1 |
Nakano, T | 1 |
Sunaga, N | 3 |
Chen, L | 1 |
Chen, Q | 1 |
Zhuang, Z | 1 |
Zhang, Y | 1 |
Tao, J | 1 |
Shen, X | 1 |
Chen, Z | 1 |
Zhu, M | 1 |
Wang, H | 1 |
Sato, D | 1 |
Kogashiwa, Y | 1 |
Tsukahara, K | 2 |
Yamauchi, K | 1 |
Kohno, N | 2 |
Tsuburaya, A | 2 |
Mizusawa, J | 1 |
Fukushima, N | 1 |
Nashimoto, A | 1 |
Sasako, M | 1 |
Ohue, M | 1 |
Hamaguchi, T | 2 |
Sakai, D | 2 |
Noura, S | 1 |
Kinugasa, Y | 1 |
Fujita, S | 1 |
Shimada, Y | 3 |
Saito, N | 1 |
Moriya, Y | 1 |
Lee, KW | 2 |
Kim, YJ | 2 |
Lee, KH | 1 |
Han, SW | 1 |
Kim, TY | 3 |
Oh, DY | 3 |
Im, SA | 2 |
Bang, YJ | 3 |
Choi, IS | 3 |
Kim, JH | 5 |
Yoshida, K | 3 |
Kobayashi, M | 1 |
Yoshino, S | 1 |
Takahashi, M | 1 |
Takiguchi, N | 1 |
Tanabe, K | 2 |
Takahashi, N | 1 |
Tatsumoto, N | 1 |
Hara, A | 1 |
Fukushima, R | 1 |
Nozaki, I | 1 |
Kojima, H | 1 |
Miyashita, Y | 1 |
Oba, K | 1 |
Buyse, M | 1 |
Sakamoto, J | 3 |
Zheng, Y | 2 |
Fang, W | 1 |
Mao, C | 1 |
Qian, J | 1 |
Zhao, P | 1 |
Zhang, X | 1 |
Jiang, H | 1 |
Xu, N | 1 |
Kobayashi, S | 2 |
Nagano, H | 2 |
Eguchi, H | 1 |
Hatano, E | 1 |
Kanai, M | 2 |
Seo, S | 1 |
Taura, K | 1 |
Fujiwara, Y | 2 |
Ajiki, T | 1 |
Takemura, S | 1 |
Kubo, S | 1 |
Yanagimoto, H | 1 |
Toyokawa, H | 1 |
Terajima, H | 1 |
Ioka, T | 1 |
Ishiwatari, H | 1 |
Yoshida, M | 1 |
Ono, M | 1 |
Sato, T | 4 |
Miyanishi, K | 2 |
Sato, Y | 3 |
Takimoto, R | 2 |
Kobune, M | 2 |
Kato, J | 2 |
Mizushima, T | 1 |
Tamagawa, H | 1 |
Matsuda, C | 1 |
Murata, K | 1 |
Fukunaga, M | 1 |
Ota, H | 1 |
Hasegawa, J | 1 |
Tsujie, M | 1 |
Fukuzaki, T | 1 |
Hata, T | 1 |
Takemasa, I | 1 |
Yamamoto, H | 1 |
Sekimoto, M | 1 |
Nezu, R | 1 |
Doki, Y | 2 |
Mori, M | 3 |
Nakamura, Y | 1 |
Fukuda, M | 1 |
Kitazaki, T | 1 |
Nagashima, S | 1 |
Takatani, H | 1 |
Nakano, H | 1 |
Nakatomi, K | 1 |
Ikeda, T | 1 |
Yamaguchi, H | 1 |
Tsukamoto, K | 1 |
Oka, M | 1 |
Kohno, S | 1 |
Takashima, T | 1 |
Mukai, H | 1 |
Hara, F | 1 |
Saito, T | 1 |
Takano, T | 1 |
Park, Y | 1 |
Toyama, T | 1 |
Hozumi, Y | 1 |
Tsurutani, J | 1 |
Imoto, S | 1 |
Watanabe, T | 1 |
Sagara, Y | 1 |
Nishimura, R | 1 |
Shimozuma, K | 1 |
Ohashi, Y | 2 |
Moriwaki, T | 1 |
Komatsu, Y | 4 |
Machida, N | 1 |
Bando, H | 1 |
Esaki, T | 1 |
Emi, Y | 3 |
Sekikawa, T | 1 |
Matsumoto, S | 3 |
Takeuchi, M | 1 |
Miyamoto, Y | 2 |
Tanioka, H | 1 |
Maekawa, S | 1 |
Kawanaka, H | 1 |
Kitazono, M | 1 |
Oki, E | 3 |
Murakami, H | 1 |
Ogata, Y | 1 |
Saeki, H | 1 |
Shimokawa, M | 1 |
Natsugoe, S | 2 |
Akagi, Y | 1 |
Maehara, Y | 4 |
Abdel-Rahman, O | 1 |
ElHalawani, H | 1 |
Essam-Eldin, S | 1 |
Kurata, M | 1 |
Okuda, Y | 1 |
Sakamoto, K | 1 |
Karasawa, K | 1 |
Chang, T | 1 |
Egawa, N | 1 |
Kamisawa, T | 1 |
Omuro, Y | 1 |
Tsuruta, K | 1 |
Tanahashi, T | 1 |
Okumura, N | 1 |
Matsuhashi, N | 1 |
Yeo, W | 1 |
Lam, KO | 1 |
Law, AL | 1 |
Lee, CC | 1 |
Chiang, CL | 1 |
Au, KH | 1 |
Mo, FK | 1 |
So, TH | 1 |
Lam, KC | 1 |
Ng, WT | 1 |
Li, L | 1 |
Arima, S | 1 |
Shimizu, K | 3 |
Okamoto, T | 2 |
Toki, M | 1 |
Suzuki, Y | 1 |
Okano, N | 1 |
Naruge, D | 1 |
Kawai, K | 1 |
Kobayashi, T | 1 |
Kasuga, A | 1 |
Kitamura, H | 1 |
Takasu, A | 1 |
Nagashima, F | 1 |
Yanagitani, N | 2 |
Aoki, H | 1 |
Kawata, T | 1 |
Utsugi, M | 2 |
Wang, R | 1 |
Lu, P | 1 |
Zhao, YF | 1 |
Lu, TY | 1 |
Han, JW | 1 |
Wang, JS | 1 |
Luo, SX | 1 |
Lu, SP | 1 |
Wang, GJ | 1 |
Geng, L | 1 |
Zhang, MZ | 1 |
Ma, ZY | 1 |
Song, M | 1 |
Wu, XA | 1 |
Chen, XB | 1 |
Jiao, ZM | 1 |
Wang, RL | 1 |
Zang, DY | 1 |
Yang, DH | 1 |
Kim, MJ | 2 |
Jang, KM | 1 |
Hwang, SW | 1 |
Yoo, KS | 1 |
Han, T | 1 |
Kim, HY | 1 |
Kim, HJ | 1 |
Kwon, JH | 1 |
Song, HH | 1 |
Park, S | 1 |
Jung, JY | 1 |
Kim, HS | 2 |
Surmont, V | 1 |
Aerts, JG | 1 |
Pouw, E | 1 |
Tan, KY | 1 |
Vernhout, R | 1 |
Gras, J | 1 |
Salomé, J | 1 |
Pronk, T | 1 |
Schmitz, PI | 1 |
Hoogsteden, H | 1 |
van Klaveren, RJ | 1 |
Lee, SJ | 1 |
Cho, SH | 1 |
Yoon, JY | 1 |
Hwang, JE | 1 |
Bae, WK | 1 |
Shim, HJ | 1 |
Chung, IJ | 1 |
Park, I | 1 |
Lee, JL | 4 |
Ryu, MH | 2 |
Chang, HM | 2 |
Kim, TW | 4 |
Sym, SJ | 1 |
Lee, SS | 3 |
Jang, G | 1 |
Yoo, C | 1 |
Bae, KS | 1 |
Kang, YK | 2 |
Cha, Y | 1 |
Yoon, SY | 1 |
Choi, IK | 1 |
Oh, SC | 1 |
Kim, CD | 1 |
Kim, JS | 1 |
Kim, YH | 1 |
Iijima, H | 1 |
Tsurumaki, H | 1 |
Saito, R | 1 |
Togawa, O | 1 |
Toda, N | 1 |
Yasuda, I | 1 |
Hasebe, O | 1 |
Maetani, I | 1 |
Tsujino, T | 1 |
Omata, M | 1 |
Akiya, T | 1 |
Sato, A | 1 |
Sakuyama, T | 1 |
Sasaki, E | 1 |
Tomidokoro, T | 1 |
Fujimori, M | 1 |
Kikuchi, Y | 1 |
Mine, T | 1 |
Kurihara, M | 1 |
Takiguchi, Y | 1 |
Tada, Y | 1 |
Kudoh, S | 3 |
Hino, M | 1 |
Yoshimori, K | 2 |
Yoshimura, A | 1 |
Nagao, K | 1 |
Niitani, H | 2 |
Yokoyama, T | 1 |
Tokuhara, H | 1 |
Egawa, T | 1 |
Hashimoto, O | 1 |
Seki, H | 1 |
Koyanagi, K | 1 |
Bessho, T | 1 |
Takayama, T | 1 |
Sagawa, T | 1 |
Takahashi, Y | 2 |
Ohnuma, H | 1 |
Okubo, S | 1 |
Shintani, N | 1 |
Tanaka, S | 1 |
Kida, M | 1 |
Ohta, H | 1 |
Hirata, K | 2 |
Niitsu, Y | 1 |
Bin, Q | 1 |
Liao, C | 1 |
Cao, Y | 1 |
Gao, F | 1 |
Yanagihara, K | 1 |
Yoshimura, K | 1 |
Niimi, M | 1 |
Yasuda, H | 1 |
Nishimura, T | 1 |
Ishiguro, H | 1 |
Kitano, T | 1 |
Misawa, A | 1 |
Tada, H | 1 |
Teramukai, S | 2 |
Mio, T | 1 |
Fukushima, M | 2 |
Park, JH | 1 |
Yoon, SN | 1 |
Lim, SB | 1 |
Yu, CS | 1 |
Jang, SJ | 1 |
Lee, JS | 2 |
Kim, JC | 1 |
Nakayama, M | 1 |
Hayakawa, K | 2 |
Okamoto, M | 1 |
Niibe, Y | 1 |
Ishiyama, H | 1 |
Kotani, S | 1 |
Ozawa, H | 1 |
Hatate, K | 1 |
Onosato, W | 1 |
Naito, M | 1 |
Nakamura, T | 1 |
Ihara, A | 1 |
Okayasu, I | 1 |
Yamashita, K | 1 |
Watanabe, M | 2 |
Nagase, T | 1 |
Kanai, T | 1 |
Nakagawa, M | 1 |
Kumamoto, Y | 1 |
Wada, O | 1 |
Honda, T | 1 |
Hoshino, G | 1 |
Atsukawa, K | 1 |
Sakaguchi, T | 1 |
Shiba, T | 1 |
Nonaka, T | 2 |
Imajyo, K | 1 |
Ogawa, Y | 1 |
Chon, HJ | 1 |
Rha, SY | 1 |
Park, HS | 1 |
Shin, SJ | 1 |
Roh, JK | 1 |
Noh, SH | 1 |
Chung, HC | 1 |
Jeung, HC | 1 |
Nagai, H | 1 |
Takamaru, N | 1 |
Ohe, G | 1 |
Uchida, D | 1 |
Tamatani, T | 1 |
Fujisawa, K | 1 |
Iwamoto, S | 2 |
Yuki, S | 3 |
Sogabe, S | 2 |
Fukushima, H | 2 |
Iwanaga, I | 2 |
Kudo, M | 3 |
Tateyama, M | 3 |
Meguro, T | 2 |
Uebayashi, M | 1 |
Saga, A | 1 |
Sakata, Y | 3 |
Asaka, M | 2 |
Ina, K | 1 |
Sugihara, M | 1 |
Haruta, J | 1 |
Shinoda, M | 1 |
Kumada, T | 1 |
Goto, H | 1 |
Ueno, H | 1 |
Yamao, K | 1 |
Funakoshi, A | 1 |
Ohkawa, S | 1 |
Yokosuka, O | 1 |
Tanaka, K | 1 |
Moriyasu, F | 1 |
Nakamori, S | 2 |
Nakayama, N | 1 |
Tanabe, S | 1 |
Higuchi, K | 1 |
Nishimura, K | 1 |
Takagi, S | 1 |
Azuma, M | 1 |
Ae, T | 1 |
Ishido, K | 1 |
Nakatani, K | 1 |
Naruke, A | 1 |
Katada, C | 1 |
Satoh, T | 1 |
Hayashi, H | 1 |
Taku, K | 1 |
Shi, X | 1 |
Brown, KH | 1 |
Yamanaka, T | 2 |
Katakami, N | 1 |
Sawa, T | 1 |
Nishimura, Y | 1 |
Fukuoka, M | 1 |
Nakatsumi, H | 1 |
Kobayashi, Y | 1 |
Nakamura, M | 1 |
Hatanaka, K | 1 |
Miyagishima, T | 1 |
Munakata, M | 2 |
Kang, MJ | 1 |
Ahn, S | 1 |
Park, DH | 1 |
Seo, DW | 1 |
Lee, SK | 1 |
Kim, MH | 1 |
Kunisaki, C | 1 |
Ono, HA | 1 |
Hasegawa, S | 1 |
Oshima, T | 1 |
Tokuhisa, M | 1 |
Izumisawa, Y | 1 |
Takagawa, R | 1 |
Kimura, J | 1 |
Kosaka, T | 1 |
Makino, H | 1 |
Akiyama, H | 1 |
Endo, I | 1 |
Kimura, Y | 2 |
Yano, H | 1 |
Fujitani, K | 2 |
Imano, M | 2 |
Tokunaga, Y | 1 |
Matsuoka, M | 1 |
Kurokawa, Y | 1 |
Shimokawa, T | 2 |
Takiuchi, H | 3 |
Tsujinaka, T | 1 |
Furukawa, H | 2 |
Zhou, Y | 1 |
Huang, J | 1 |
Yang, L | 1 |
Chi, Y | 1 |
Qu, T | 1 |
Lü, X | 1 |
Wang, JW | 1 |
Nishino, H | 1 |
Shinozaki, T | 1 |
Ishikawa, K | 1 |
Tanaka, H | 1 |
Ichimura, K | 1 |
Goto, A | 2 |
Arai, T | 1 |
Ura, T | 1 |
Shirao, K | 2 |
Tujie, M | 1 |
Maruhashi, S | 1 |
Miyamoto, A | 1 |
Dono, K | 1 |
Umeshita, K | 1 |
Sakon, M | 1 |
Monden, M | 2 |
Hino, S | 1 |
Shintani, S | 1 |
Hara, S | 1 |
Hamakawa, H | 1 |
Hirakawa, K | 2 |
Nakata, B | 2 |
Saji, S | 1 |
Saeki, T | 2 |
Takashima, S | 2 |
Sano, M | 2 |
Horikoshi, N | 2 |
Miura, S | 1 |
Shimizu, S | 1 |
Morimoto, K | 2 |
Taguchi, T | 2 |
Nakazawa, M | 2 |
Ohnishi, T | 1 |
Chisoku, H | 1 |
Katagiri, W | 1 |
Doi, T | 1 |
Takase, T | 1 |
Yui, S | 1 |
Miwa, Y | 1 |
Fukuda, Y | 1 |
Kishino, M | 1 |
Yura, Y | 1 |
Fujita, J | 1 |
Kan, K | 1 |
Takiguchi, S | 1 |
Miyata, H | 1 |
Yasuda, T | 1 |
Ito, K | 1 |
Takahashi, I | 2 |
Kakeji, Y | 2 |
Tokunaga, E | 1 |
Ushiro, S | 1 |
Wataya, H | 2 |
Asou, H | 1 |
Maruyama, R | 1 |
Suemitsu, R | 1 |
Ishida, H | 2 |
Akita, H | 1 |
Watanabe, Y | 1 |
Nakaguchi, K | 1 |
Kabuto, T | 1 |
Yoshioka, K | 1 |
Shitara, K | 1 |
Kudou, T | 1 |
Ohtsu, A | 1 |
Wada, Y | 1 |
Ukon, K | 1 |
Hihara, J | 1 |
Egashira, A | 1 |
Morita, M | 1 |
Eguchi, T | 1 |
Fujii, M | 1 |
Tahara, M | 1 |
Yumine, K | 1 |
Kawahara, M | 2 |
Kawamura, S | 1 |
Yamagishi, D | 1 |
Tei, M | 1 |
Sumi, Y | 1 |
Shimada, E | 1 |
Okumura, S | 1 |
Yoshino, T | 1 |
Fukutomi, A | 1 |
Mitachi, Y | 1 |
Yamamitsu, S | 1 |
Takeuchi, T | 1 |
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Rivera, F | 1 |
Vega-Villegas, ME | 1 |
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Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
A Prospective, Single-arm Study of Simultaneous Modulated Accelerated Radiotherapy Combined With S-1/DDP for Elderly Esophageal Squamous Cell Carcinoma.[NCT02606916] | Phase 2 | 42 participants (Actual) | Interventional | 2015-07-31 | Completed | ||
Phase II Study of Paclitaxel Liposome Plus S-1 as Neoadjuvant Chemotherapy for Advanced Gastric Cancer[NCT02163291] | Phase 2 | 30 participants (Anticipated) | Interventional | 2013-12-31 | Not yet recruiting | ||
Apatinib Plus XELOX Regime as Neoadjuvant Therapy in Locally Advanced Gastric Cancer Patients With Lymph Node Metastasis[NCT03229096] | Phase 2 | 35 participants (Anticipated) | Interventional | 2017-02-01 | Recruiting | ||
A Prospective,Multicentral,Open-label,Randomized,Controlled,Phase III Clinical Trial to Compare S-1 for 6 Months to 1 Year as Adjuvant Chemotherapy After D2 Resection in Patients With Gastric Cancer Staged II , IIIA or IIIB.[NCT02736552] | Phase 3 | 0 participants (Actual) | Interventional | 2016-03-31 | Withdrawn | ||
Phase I Study of Gemcitabine or S-1 Adjuvant Therapy After Hemihepatectomy for Biliary Tract Cancer[NCT01291615] | Phase 1 | 6 participants (Actual) | Interventional | 2010-12-31 | Completed | ||
Phase II Trial of Cisplatin Combined With Oral TS-1 in Patients With Advanced Solid Tumors With Different Degrees of Liver Dysfunction[NCT03519074] | Phase 2 | 48 participants (Anticipated) | Interventional | 2016-07-22 | Recruiting | ||
Phase II Trial of Gemcitabine and S-1 for Patients With Advanced Biliary Tract Cancer[NCT02146703] | Phase 2 | 38 participants (Actual) | Interventional | 2005-08-31 | Completed | ||
Phase II Trial of Combination Therapy With Irinotecan, S-1, and Bevacizumab (IRIS/Bev) in Patients With Unresectable or Recurrent Colorectal Cancer[NCT00569790] | Phase 2 | 53 participants (Actual) | Interventional | 2007-10-31 | Completed | ||
PD-1 Antibody Plus Gemcitabine and Oxaliplatin (GEMOX) as Postoperative Adjuvant Therapy in Perihilar Cholangiocarcinoma Patients With Positively Metastatic Lymph Nodes : a Single Arm, Phase II Trial[NCT05430698] | Phase 2 | 62 participants (Anticipated) | Interventional | 2023-01-31 | Recruiting | ||
Randomized Phase II Trial of SP vs. GP in Advanced Biliary Cancer[NCT01375972] | Phase 2 | 92 participants (Actual) | Interventional | 2008-03-31 | Completed | ||
Phase III Trial of S-1 and Cisplatin (3 Weekly) Versus S-1 and Oxaliplatin Combination Chemotherapy for First Line Treatment of Advanced Gastric Cancer[NCT01671449] | Phase 3 | 338 participants (Actual) | Interventional | 2012-12-31 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
9 reviews available for tegafur and Neutropenia
Article | Year |
---|---|
S-1-based regimens and the risk of leucopenic complications; a Meta-analysis with comparison to other fluoropyrimidines and non fluoropyrimidines.
Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials, Phase II as Topic; Clinical Trials, | 2016 |
Oral uracil-tegafur plus leucovorin vs fluorouracil bolus plus leucovorin for advanced colorectal cancer: a meta-analysis of five randomized controlled trials.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Diarrhea; Fluorouracil; Humans | 2011 |
[S-1 for gastric cancer-S-1 monotherapy and its progress].
Topics: Administration, Oral; Anemia; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy | 2006 |
[Combination chemotherapy of S-1 plus biweekly docetaxel for advanced and recurrent gastric cancer].
Topics: Animals; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials, Phase I as Topic | 2006 |
[S-1 as a single agent for colorectal cancer].
Topics: Administration, Oral; Anorexia; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherap | 2006 |
[The current evidence of S-1 and irinotecan hydrochloride combination chemotherapy with tri-weekly schedule].
Topics: Adult; Aged; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Clinical Trials | 2006 |
[Combination therapy with S-1 and CDDP for head and neck cancer].
Topics: Adult; Aged; Anemia; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Carcinom | 2006 |
[Combination chemotherapy with S-1 and cisplatin for non-small cell lung cancer].
Topics: Administration, Oral; Anemia; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, N | 2006 |
[Clinical benefit of S-1 in metastatic breast cancer].
Topics: Administration, Oral; Anemia; Antimetabolites, Antineoplastic; Breast Neoplasms; Carcinoma, Ductal, | 2006 |
79 trials available for tegafur and Neutropenia
Article | Year |
---|---|
Phase II feasibility study of adjuvant chemotherapy with docetaxel/cisplatin/S-1 followed by S-1 for stage III gastric cancer.
Topics: Adenocarcinoma; Aged; Anemia; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy | 2021 |
A phase I and extension study of S-1 and carboplatin for previously untreated patients aged 75 years or more with advanced non-small cell lung cancer -TCOG 1101.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Carboplat | 2020 |
A single-arm, phase 2 study of adjuvant chemotherapy with oral tegafur-uracil for pathologically lymphovascular invasion positive stage IA non-small cell lung cancer: LOGIK0602 study.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Blood Vessels; Carcinoma, Non-Small-Cell Lung; | 2020 |
Comparative study of cisplatin-based definitive concurrent chemoradiotherapy with S-1 versus paclitaxel for unresectable locally advanced esophageal squamous cell carcinoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemoradiotherapy; Cisplat | 2017 |
[Efficacy and safety of Xiaoaiping combined with chemotherapy in the treatment of advanced esophageal cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Disease-Free Survival; Drug Combinations; | 2017 |
Phase II study of S-1 plus leucovorin in patients with metastatic colorectal cancer: Regimen of 1 week on, 1 week off.
Topics: Adult; Aged; Aged, 80 and over; Anorexia; Antineoplastic Combined Chemotherapy Protocols; China; Col | 2017 |
A single-arm, phase II trial of neoadjuvant gemcitabine and S1 in patients with resectable and borderline resectable pancreatic adenocarcinoma: PREP-01 study.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; CA-1 | 2019 |
Japanese subgroup analysis of a phase III study of S-1 versus docetaxel in non-small cell lung cancer patients after platinum-based treatment: EAST-LC.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Carcinoma, Non-Small-Cell Lung; Dis | 2019 |
Sex differences in the safety of S-1 plus oxaliplatin and S-1 plus cisplatin for patients with metastatic gastric cancer.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Disease-Free Survival; Dose-Respons | 2019 |
Randomized phase II trial of uracil/tegafur and cisplatin versus vinorelbine and cisplatin with concurrent thoracic radiotherapy for locally advanced unresectable stage III non-small-cell lung cancer: NJLCG 0601.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cisplat | 2013 |
Concurrent chemoradiotherapy with a novel fluoropyrimidine, S-1, and cisplatin for locally advanced esophageal cancer: long-term results of a phase II trial.
Topics: Aged; Aged, 80 and over; Anemia; Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy; | 2013 |
Phase II clinical trial of metronomic chemotherapy with combined irinotecan and tegafur-gimeracil-oteracil potassium in metastatic and recurrent breast cancer.
Topics: Administration, Metronomic; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neop | 2015 |
Phase I clinical and pharmacokinetic/pharmacogenetic study of a triplet regimen of S-1/irinotecan/oxaliplatin in patients with metastatic colorectal or gastric cancer.
Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aryl Hydrocarbon Hydro | 2013 |
Phase II study of oral S-1 and cisplatin with concurrent radiotherapy for locally advanced non-small-cell lung cancer.
Topics: Adult; Aged; Carcinoma, Non-Small-Cell Lung; Chemoradiotherapy; Cisplatin; Disease-Free Survival; Dr | 2013 |
Phase I study of nedaplatin prior to S-1 in patients with locally advanced head and neck squamous cell carcinoma.
Topics: Administration, Oral; Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Drug Administration Sch | 2013 |
Neoadjuvant chemotherapy with S-1 and cisplatin followed by D2 gastrectomy with para-aortic lymph node dissection for gastric cancer with extensive lymph node metastasis.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adj | 2014 |
A phase I trial of preoperative S-1 in combination with oxaliplatin and pelvic radiation for lower rectal cancer with T4 and lateral pelvic lymph node metastasis.
Topics: Adenocarcinoma; Adult; Aged; Alanine Transaminase; Antineoplastic Combined Chemotherapy Protocols; A | 2015 |
Phase II trial of gemcitabine plus UFT as salvage treatment in oxaliplatin, irinotecan and fluoropyrimidine-refractory metastatic colorectal cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Deo | 2014 |
Sequential paclitaxel followed by tegafur and uracil (UFT) or S-1 versus UFT or S-1 monotherapy as adjuvant chemotherapy for T4a/b gastric cancer (SAMIT): a phase 3 factorial randomised controlled trial.
Topics: Adenocarcinoma; Aged; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuva | 2014 |
Biweekly S-1 plus paclitaxel (SPA) as second-line chemotherapy after failure from fluoropyrimidine and platinum in advanced gastric cancer: a phase II study.
Topics: Administration, Oral; Adult; Aged; Anemia; Antineoplastic Combined Chemotherapy Protocols; Asian Peo | 2014 |
Phase I study of adjuvant gemcitabine or S-1 in patients with biliary tract cancers undergoing major hepatectomy: KHBO1003 study.
Topics: Aged; Antimetabolites, Antineoplastic; Biliary Tract Neoplasms; Chemotherapy, Adjuvant; Deoxycytidin | 2014 |
Phase I trial of oral S-1 combined with hepatic arterial infusion of gemcitabine in unresectable biliary tract cancer.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biliary Tract Neo | 2015 |
Phase II Study of Oral Tegafur/Uracil and Leucovorin plus Bevacizumab as a First-Line Therapy for Elderly Patients with Advanced or Metastatic Colorectal Cancer.
Topics: Administration, Oral; Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy | 2015 |
A Phase II Study of S-1 for Previously Untreated Elderly Patients with Advanced Non-Small Cell Lung Cancer.
Topics: Aged; Aged, 80 and over; Anemia; Antimetabolites, Antineoplastic; Carcinoma, Non-Small-Cell Lung; Dr | 2016 |
Taxanes versus S-1 as the first-line chemotherapy for metastatic breast cancer (SELECT BC): an open-label, non-inferiority, randomised phase 3 trial.
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Disease | 2016 |
S-1 plus leucovorin versus S-1 plus leucovorin and oxaliplatin versus S-1 plus cisplatin in patients with advanced gastric cancer: a randomised, multicentre, open-label, phase 2 trial.
Topics: Adenocarcinoma; Aged; Anemia; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Disease-Fre | 2016 |
S-1 and irinotecan plus bevacizumab as second-line chemotherapy for patients with oxaliplatin-refractory metastatic colorectal cancer: a multicenter phase II study in Japan (KSCC1102).
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colorectal N | 2016 |
A Phase I Study of S-1 and Gemcitabine with Concurrent Radiotherapy in Patients with Non-Metastatic Advanced Pancreatic Cancer.
Topics: Aged; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Pancreatic Ductal; Chemor | 2015 |
Phase II trial of neoadjuvant chemotherapy with docetaxel, nedaplatin, and S1 for advanced esophageal squamous cell carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Squamous Cell; Docetaxel; Drug Com | 2016 |
A Multicenter Phase II Study of Gemcitabine plus S-1 Chemotherapy for Advanced Biliary Tract Cancer.
Topics: Administration, Intravenous; Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Co | 2017 |
Phase I trial of oral S-1 plus gemcitabine in elderly patients with nonsmall cell lung cancer.
Topics: Administration, Oral; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carci | 2008 |
Oral UFT, etoposide and leucovorin in recurrent non-small cell lung cancer: a non-randomized phase II study.
Topics: Administration, Oral; Alopecia; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small | 2009 |
Phase II study of S-1 monotherapy in paclitaxel- and cisplatin-refractory gastric cancer.
Topics: Adenocarcinoma; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic | 2009 |
Phase I/II and pharmacokinetic study of S-1 and oxaliplatin in previously untreated advanced gastric cancer.
Topics: Adult; Anemia; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Dose-Response Relat | 2010 |
A multicenter phase II study of gemcitabine and S-1 combination chemotherapy in patients with unresectable pancreatic cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Drug Combinations; Fatig | 2010 |
Phase 2 study of S-1 plus carboplatin in patients with advanced non-small cell lung cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Non-Small-Cell | 2010 |
Multicenter, phase II study of gemcitabine and S-1 combination chemotherapy in patients with advanced biliary tract cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biliary Tract Neoplasms; Deoxycytidine; | 2010 |
Phase II study of S-1 as first-line treatment for elderly patients over 75 years of age with advanced gastric cancer: the Tokyo Cooperative Oncology Group study.
Topics: Aged; Aged, 80 and over; Anorexia; Antimetabolites, Antineoplastic; Drug Combinations; Fatigue; Fema | 2010 |
Phase I/II study of docetaxel and S-1, an oral fluorinated pyrimidine, for untreated advanced non-small cell lung cancer.
Topics: Administration, Oral; Adult; Aged; Carcinoma, Non-Small-Cell Lung; Disease Progression; Docetaxel; D | 2010 |
Phase II study of S-1, docetaxel and cisplatin combination chemotherapy in patients with unresectable metastatic gastric cancer.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogen | 2010 |
Phase II study of S-1 and docetaxel for previously treated patients with locally advanced or metastatic non-small cell lung cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Disease | 2010 |
Phase I study of preoperative chemoradiation with s-1 and oxaliplatin in patients with locally advanced resectable rectal cancer.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Thera | 2011 |
Phase I/II trial of concurrent use of S-1 and radiation therapy for T2 glottic cancer.
Topics: Aged; Aged, 80 and over; Anemia; Carcinoma, Squamous Cell; Combined Modality Therapy; Drug Administr | 2010 |
A Phase II trial of neoadjuvant preoperative chemoradiotherapy with S-1 plus irinotecan and radiation in patients with locally advanced rectal cancer: clinical feasibility and response rate.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols | 2011 |
Salvage chemotherapy of biweekly irinotecan plus S-1 (biweekly IRIS) in previously treated patients with advanced gastric cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Diarrhea; Disease-Free Su | 2011 |
Phase II study of combined treatment with irinotecan and S-1 (IRIS) in patients with inoperable or recurrent advanced colorectal cancer (HGCSG0302).
Topics: Adenocarcinoma; Adult; Aged; Anemia; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; C | 2011 |
A phase II multi-center study of triple therapy with paclitaxel, S-1 and cisplatin in patients with advanced gastric cancer.
Topics: Adult; Aged; Anemia; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Disease-Free Surviva | 2011 |
Multicenter phase II study of gemcitabine and S-1 combination therapy (GS Therapy) in patients with metastatic pancreatic cancer.
Topics: Adenocarcinoma; Adult; Aged; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Ad | 2011 |
A multicenter phase II study of combined chemotherapy with docetaxel, cisplatin, and S-1 in patients with unresectable or recurrent gastric cancer (KDOG 0601).
Topics: Adult; Aged; Anemia; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Docetaxel; Drug Admi | 2012 |
Phase I study of cediranib in combination with cisplatin plus fluoropyrimidine (S-1 or capecitabine) in Japanese patients with previously untreated advanced gastric cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Appetite; Area Under Curve; Asian Peopl | 2012 |
S-1 plus cisplatin with concurrent radiotherapy for locally advanced non-small cell lung cancer: a multi-institutional phase II trial (West Japan Thoracic Oncology Group 3706).
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Chemora | 2011 |
Phase II study of combined chemotherapy with irinotecan and S-1 (IRIS) plus bevacizumab in patients with inoperable recurrent or advanced colorectal cancer.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antineoplastic Combined | 2012 |
Randomized phase II trial of S-1 and cisplatin versus gemcitabine and cisplatin in patients with advanced biliary tract adenocarcinoma.
Topics: Adenocarcinoma; Adult; Aged; Anemia; Antineoplastic Combined Chemotherapy Protocols; Asthenia; Bilia | 2012 |
Randomized phase II trial of S-1 and cisplatin versus gemcitabine and cisplatin in patients with advanced biliary tract adenocarcinoma.
Topics: Adenocarcinoma; Adult; Aged; Anemia; Antineoplastic Combined Chemotherapy Protocols; Asthenia; Bilia | 2012 |
Randomized phase II trial of S-1 and cisplatin versus gemcitabine and cisplatin in patients with advanced biliary tract adenocarcinoma.
Topics: Adenocarcinoma; Adult; Aged; Anemia; Antineoplastic Combined Chemotherapy Protocols; Asthenia; Bilia | 2012 |
Randomized phase II trial of S-1 and cisplatin versus gemcitabine and cisplatin in patients with advanced biliary tract adenocarcinoma.
Topics: Adenocarcinoma; Adult; Aged; Anemia; Antineoplastic Combined Chemotherapy Protocols; Asthenia; Bilia | 2012 |
Low-dose docetaxel and cisplatin combination chemotherapy for stage II/III gastric cancer showing resistance to S-1 adjuvant chemotherapy: a phase I study.
Topics: Aged; Anorexia; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, | 2012 |
A phase I study of triplet combination chemotherapy of paclitaxel, cisplatin and S-1 in patients with advanced gastric cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Schedule | 2013 |
Phase I study of irinotecan and S-1 combination therapy in patients with metastatic gastric cancer.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Dru | 2003 |
[Phase I study of gemcitabine (GEM) and UFT combination chemotherapy for unresectable/recurrent pancreatic cancer].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Drug Administration Schedule; D | 2004 |
Phase I/II study of combination therapy of oral fluorinated pyrimidine compound S-1 with low-dose cisplatin in patients with unresectable and/or recurrent advanced gastric cancer: a novel study design to evaluate safety and efficacy.
Topics: Administration, Oral; Adult; Aged; Ambulatory Care; Antineoplastic Combined Chemotherapy Protocols; | 2004 |
[A late phase II clinical study of S-1 in patients with progressed, refractory breast cancer].
Topics: Adult; Aged; Anorexia; Antimetabolites, Antineoplastic; Breast Neoplasms; Diarrhea; Drug Administrat | 2004 |
[A phase I study of combination chemotherapy using TS-1 and weekly paclitaxel for advanced gastric cancer].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Drug | 2006 |
Phase I study of S-1 and biweekly docetaxel combination chemotherapy for advanced and recurrent gastric cancer.
Topics: Adult; Aged; Alopecia; Anemia; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Area Under | 2006 |
[A case of adenocarcinoma of the lung significantly responding to TS-1 plus cisplatin combination chemotherapy].
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cisplatin; Dr | 2006 |
[Combination chemotherapy of S-1 and docetaxel on advanced and recurrent gastric cancer].
Topics: Adult; Aged; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Docetaxel; Drug Administratio | 2006 |
[Irinotecan plus oral S-1 in patients with advanced colorectal cancer--biweekly IRIS regimen].
Topics: Administration, Oral; Adult; Aged; Alopecia; Antineoplastic Combined Chemotherapy Protocols; Camptot | 2006 |
[Concurrent chemoradiotherapy (CRT) with S-1 and cisplatin (CDDP) in patients (pts) with locally advanced head and neck cancer (HNC)].
Topics: Adult; Aged; Anemia; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cispl | 2006 |
[Phase II study of S-1, a novel oral fluorouracil, in advanced non-small-cell lung cancer].
Topics: Administration, Oral; Adult; Aged; Anorexia; Antimetabolites, Antineoplastic; Carcinoma, Non-Small-C | 2006 |
[Preoperative chemotherapy with S-1 and low-dose cisplatin for oral squamous cell carcinoma].
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anorexia; Antineoplastic Combined Chemotherapy | 2006 |
Long term results of a phase II trial of induction chemotherapy with uracil-ftegafur (UFT), vinorelbine and cisplatin (UFTVP) followed by radiotherapy concomitant with UFT and carboplatin (RT/UFTJ) in non-resectable locally advanced (stage IV-B) squamous
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Car | 2007 |
Phase I/II study of 3-week combination of S-1 and cisplatin chemotherapy for metastatic or recurrent gastric cancer.
Topics: Adult; Aged; Anemia; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Diarrhea; | 2008 |
A phase II trial of S-1 and cisplatin in patients with metastatic or relapsed biliary tract cancer.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biliary Tract Neoplasms | 2008 |
Multi-center phase II study for combination therapy with paclitaxel/doxifluridine to treat advanced/recurrent gastric cancer showing resistance to S-1 (OGSG 0302).
Topics: Adenocarcinoma; Aged; Anemia; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Disease-Free | 2008 |
A multicenter phase II study of biweekly paclitaxel and S-1 combination chemotherapy for unresectable or recurrent gastric cancer.
Topics: Adenocarcinoma; Aged; Alopecia; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Disease Pr | 2008 |
A comparative study of oral tegafur and intravenous 5-fluorouracil in patients with metastatic colorectal cancer.
Topics: Administration, Oral; Colonic Neoplasms; Drug Evaluation; Female; Fluorouracil; Humans; Injections, | 1983 |
Neoadjuvant therapy with cisplatin/fluorouracil vs cisplatin/UFT in locally advanced squamous cell head and neck cancer.
Topics: Adult; Aged; Alopecia; Anemia; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous C | 1997 |
[An early phase II clinical study of S-1 in patients with breast cancer. S-1 Cooperative Study Group (Breast Cancer Working Group)].
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Breast Neoplasms; Drug Administrati | 1998 |
[Early phase II study of S-1 in patients with advanced head and neck cancer. S-1 Cooperative Study Group (Head and Neck Working Group)].
Topics: Administration, Oral; Adult; Aged; Anorexia; Antimetabolites, Antineoplastic; Carcinoma, Squamous Ce | 1998 |
A phase I study of combined UFT plus leucovorin and radiotherapy for pancreatic cancer.
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Dia | 2000 |
UFT/leucovorin plus bolus epirubicin and cyclophosphamide in advanced/metastatic breast cancer.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; | 2000 |
Phase II study of S-1, a novel oral fluorouracil, in advanced non-small-cell lung cancer.
Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Carcinoma, Non-Small-Cell Lung; | 2001 |
32 other studies available for tegafur and Neutropenia
Article | Year |
---|---|
Efficacy and safety of gemcitabine plus S-1 in pancreatic cancer: a pooled analysis of individual patient data.
Topics: Aftercare; Aged; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials, Phase II as Topic; | 2017 |
S-1 (Teysuno) and gemcitabine in Caucasian patients with unresectable pancreatic adenocarcinoma.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Coho | 2018 |
Risk factors for severe neutropenia induced by combination therapy of S-1 and cisplatin in patients with advanced/recurrent gastric cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Combinations; Female; H | 2018 |
Feasibility study of postoperative adjuvant chemotherapy with S-1 in patients with biliary tract cancer.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Biliary Tract Neoplasms; Carcinoma, Papillary; Carcino | 2018 |
Toxicity and Efficacy of Sequential Chemotherapy in Patients with p-stage I Non-small Cell Lung Cancer that Recurring during Postoperative Tegafur-Uracil Adjuvant Chemotherapy.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell L | 2018 |
[The Case of a Patient with Gastric Cancer Who Showed No Neutropenia Only When Using the Generic S-1 Adjuvant Chemotherapy Formulation].
Topics: Aged; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Drug Combinations; Drugs, Generic; Fe | 2018 |
Fluoropyrimidine with or without platinum as first-line chemotherapy in patients with advanced gastric cancer and severe peritoneal metastasis: a multicenter retrospective study.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Ascites; Cisplatin; | 2019 |
A retrospective study of S-1 and oxaliplatin combination chemotherapy in patients with refractory pancreatic cancer.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemo | 2013 |
The association between neutropenia and prognosis in stage III colorectal cancer patients receiving adjuvant chemotherapy.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Chemother | 2014 |
Effect of the weekly administration of liposome-Paclitaxel combined with s-1 on advanced gastric cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Diarrhea; Disease-Free Survival; Drug A | 2014 |
Adjuvant S-1 chemotherapy after curative resection of gastric cancer in Chinese patients: assessment of treatment tolerability and associated risk factors.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Anemia; Antimetabolites, Antineoplastic; Chemotherap | 2017 |
[Nedaplatin combined with tegafur in the treatment for advanced esophageal cancer].
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cel | 2008 |
Dose-finding study of docetaxel, oxaliplatin, and S-1 for patients with advanced gastric cancer.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemo | 2009 |
[The efficacy of S-1 monotherapy as a 2nd/3rd-line therapy for unresectable recurrent colon cancer: Kanagawa conference of clinical oncology (KCCO)].
Topics: Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Dise | 2009 |
[Analysis of four patients with advanced gastric cancer undergoing gastrectomy after pre-operative combination chemotherapy using docetaxel, cisplatin and S-1].
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy P | 2010 |
[Evaluation of combination chemotherapy with oral S-1 administration followed by docetaxel by superselective intra-arterial infusion for patients with oral squamous cell carcinomas].
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols | 2011 |
[A safety analysis in patients treated with oxaliplatin plus S-1 as adjuvant therapy for gastric cancer].
Topics: Adenocarcinoma; Adult; Aged; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, | 2012 |
[Adverse reactions to TS-1 for outpatients with recurrent head and neck cancer].
Topics: Adult; Aged; Ambulatory Care; Antimetabolites, Antineoplastic; Drug Administration Schedule; Drug Co | 2002 |
[A case of advanced maxillary carcinoma with cervical lymph node metastases showing a complete response to the combination therapy of CDDP, TS-1 and radiation].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemotherapy, Adjuva | 2004 |
[Preoperative chemotherapy with TS-1 and low dose cisplatin for oral squamous cell carcinoma patients--a preliminary study].
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous | 2005 |
[Example of safety measures for antineoplastic agents immediately after market launch--a case of TS-1 capsule all example use result investigation that executes safety monitoring--].
Topics: Antimetabolites, Antineoplastic; Capsules; Drug Administration Schedule; Drug Combinations; Drug Mon | 2006 |
[Complete response to CPT-11 and UFT/LV combination therapy in a case with simultaneous multiple lung metastases from colon cancer].
Topics: Adenocarcinoma; Alopecia; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neop | 2006 |
[24 hour infusion of CPT-11/oral UFT/LV].
Topics: Administration, Oral; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colore | 2006 |
[Japanese nationwide post-marketing survey of S-1 in patients with advanced gastric cancer].
Topics: Aged; Anorexia; Antimetabolites, Antineoplastic; Drug Administration Schedule; Drug Combinations; Dr | 2006 |
[A case of non-curatively resected gastric cancer successfully treated over 17 months with TS-1 and irinotecan combination therapy].
Topics: Anorexia; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Combined Modality Therapy; D | 2006 |
[Chemotherapy-naïve advanced pancreatic cancer with multiple liver metastases successfully treated by S-1 monotherapy--a case report].
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Clinical Trials, Phase II as Topic; Deoxycytidine; | 2006 |
Moderate neutropenia with S-1 plus low-dose cisplatin may predict a more favourable prognosis in advanced gastric cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Combinations; Female; H | 2006 |
Predictive value of chemotherapy-induced neutropenia for the efficacy of oral fluoropyrimidine S-1 in advanced gastric carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Drug Combinations; Female; Humans; | 2007 |
[Good response in ARDS treated with sivelestat sodium hydrate during chemotherapy for cholangiocarcinoma].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; | 2007 |
Sequential chemotherapy for adenocarcinoma of unknown primary.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; | 1983 |
Granulocyte colony-stimulating factor (G-CSF) as an adjunct to induction chemotherapy of adult acute lymphoblastic leukemia (ALL).
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Marrow Cell | 1993 |
Preliminary results. UFT/methotrexate/leucovorin for breast Ca patients in progression after HDCT/PBPC support.
Topics: Adult; Anemia; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Diarrhea | 1997 |