tegafur has been researched along with Experimental Neoplasms in 55 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Multidrug resistant H22 (H22/FAP) hepatocellular carcinoma cells were produced in vitro by continuous exposure to increasing doses of doxorubicin, cisplatin and 5-fluorouracil (FAP regimen)." | 7.79 | Association between reversal of multidrug resistance by methyl jasmonate and P-glycoprotein ATPase activity in hepatocellular carcinoma. ( Huang, FZ; Jiang, XZ; Liu, XY; Nie, WP; Wang, CF; Wang, YQ, 2013) |
| "A significant inhibition of the growth of adenocarcinoma 755 tumors in BDF1 mice was effected by oral tegafur (FT) in combination with oral (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVdUrd), at doses at which neither drug used alone had antitumor activity." | 7.67 | The antitumor potency of oral tegafur against adenocarcinoma 755 in mice is markedly enhanced by oral (E)-5-(2-bromovinyl)-2'-deoxyuridine. ( De Clercq, E; Hoshi, A; Iigo, M; Nishimura, S; Yamaizumi, Z, 1987) |
| "Multidrug resistant H22 (H22/FAP) hepatocellular carcinoma cells were produced in vitro by continuous exposure to increasing doses of doxorubicin, cisplatin and 5-fluorouracil (FAP regimen)." | 3.79 | Association between reversal of multidrug resistance by methyl jasmonate and P-glycoprotein ATPase activity in hepatocellular carcinoma. ( Huang, FZ; Jiang, XZ; Liu, XY; Nie, WP; Wang, CF; Wang, YQ, 2013) |
| "A significant inhibition of the growth of adenocarcinoma 755 tumors in BDF1 mice was effected by oral tegafur (FT) in combination with oral (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVdUrd), at doses at which neither drug used alone had antitumor activity." | 3.67 | The antitumor potency of oral tegafur against adenocarcinoma 755 in mice is markedly enhanced by oral (E)-5-(2-bromovinyl)-2'-deoxyuridine. ( De Clercq, E; Hoshi, A; Iigo, M; Nishimura, S; Yamaizumi, Z, 1987) |
| " The antitumor activity of this compound was superior to those of 5-FU and 1-(2-tetrahydrofuryl)-5-fluorouracil (Tegafur, Ftorafur) in the treatment of transplantable tumors, not only 5-FU-sensitive tumors such as adenocarcinoma 755, lymphosarcoma LS-1, and plasmacytoma X5563, but also 5-FU-resistant tumors such as Lewis lung carcinoma and Walker carcinosarcoma 256." | 3.66 | Antitumor activity of methyl (5-fluoro-1H-2-oxo-4-pyrimidinyl beta-D-glucopyranosid)uronate against various experimental tumors. ( Arakawa, M; Inomata, T; Sasagawa, K; Shimizu, F; Shinkai, K, 1981) |
| " These findings suggest that local DC therapy in combination with TS-1 and OK-432 may well be a useful strategy for the treatment of solid tumors, and that TLR4 signaling is involved in the success of this therapy." | 1.32 | [Anti-tumor effect of intratumoral administration of dendritic cells in combination with TS-1 and OK-432]. ( Ahmed, SU; Okamoto, M; Oshikawa, T; Sato, M; Tano, T, 2004) |
| " The bioavailability of UK-21 given p." | 1.28 | Antitumor activity of two novel low immunosuppressive fluoropyrimidines UK-21 and UK-25. ( Kato, T; Kitaichi, K; Koda, A; Mori, H; Sakamoto, O, 1992) |
| " The recommended dosage for daily oral administration of FD-1 is 6-12 mg/kg/day." | 1.26 | Review of a new antimetabolic agent, 1,3-bis(tetrahydro-2-furanyl)-5-fluoro-2,4-pyrimidinedione (FD-1). ( Taguchi, T, 1980) |
| "These xenografts were 1 line of rectal cancer (H-26), two lines of gastric cancer (H-08 and H-22), and 1 line of breast cancer (H-62)." | 1.26 | Relationship of chemotherapy on human cancer xenografts in nude mice to clinical response in donor patient. ( Fujita, M; Hayata, S; Taguchi, T, 1980) |
| " The results confirm that it is possible to compare phenotypical normal with nude mice both with regard to dosage levels and therapeutic activity." | 1.26 | Toxicologic and therapeutic examinations with ftorafur in different mouse strains. ( Arnold, W; Fichtner, I; Naundorf, H, 1981) |
| "Urinary bladder tumors were induced in 18 of 20 rats (90." | 1.26 | [Effect of FT-207 on bladder cancer in rats induced by BBN. II: The effect of oral administration of FT-207 during oncogenesis of bladder cancer]. ( Babaya, K; Hiramatsu, T; Hirao, Y; Ijuin, M; Kihoin, K; Maruyama, Y; Ohara, S; Okajima, E; Tanaka, M, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 39 (70.91) | 18.7374 |
| 1990's | 10 (18.18) | 18.2507 |
| 2000's | 4 (7.27) | 29.6817 |
| 2010's | 1 (1.82) | 24.3611 |
| 2020's | 1 (1.82) | 2.80 |
| Authors | Studies |
|---|---|
| Yasumoto, M | 2 |
| Moriyama, A | 1 |
| Unemi, N | 2 |
| Hashimoto, S | 2 |
| Suzue, T | 1 |
| Yamawaki, I | 1 |
| Marunaka, T | 2 |
| Lin, TS | 1 |
| Wang, L | 1 |
| Antonini, I | 1 |
| Cosby, LA | 1 |
| Shiba, DA | 1 |
| Kirkpatrick, DL | 1 |
| Sartorelli, AC | 1 |
| Hronowski, LJ | 1 |
| Szarek, WA | 1 |
| Kametani, T | 2 |
| Kigasawa, K | 2 |
| Hiiragi, M | 2 |
| Wakisaka, K | 2 |
| Nakazato, K | 1 |
| Ichikawa, K | 1 |
| Fukawa, K | 2 |
| Irino, O | 2 |
| Nishimura, N | 2 |
| Okada, T | 2 |
| Haga, S | 1 |
| Nagamatsu, Y | 1 |
| Sugi, H | 1 |
| Yamamoto, T | 1 |
| Taguchi, A | 1 |
| Nakayama, M | 1 |
| Yang, WS | 1 |
| Qi, XR | 1 |
| Xu, QZ | 1 |
| Yuan, CH | 1 |
| Yi, YH | 1 |
| Tang, HF | 1 |
| Shen, L | 1 |
| Han, H | 1 |
| Wang, CF | 1 |
| Wang, YQ | 1 |
| Huang, FZ | 1 |
| Nie, WP | 1 |
| Liu, XY | 1 |
| Jiang, XZ | 1 |
| Nakajima, Y | 1 |
| Gotanda, T | 1 |
| Uchimiya, H | 1 |
| Furukawa, T | 1 |
| Haraguchi, M | 1 |
| Ikeda, R | 1 |
| Sumizawa, T | 1 |
| Yoshida, H | 1 |
| Akiyama, S | 1 |
| Okamoto, M | 1 |
| Ahmed, SU | 1 |
| Oshikawa, T | 1 |
| Tano, T | 1 |
| Sato, M | 2 |
| Mushiake, H | 1 |
| Tsunoda, T | 1 |
| Nukatsuka, M | 2 |
| Shimao, K | 1 |
| Fukushima, M | 2 |
| Tahara, H | 1 |
| Yamashita, T | 1 |
| Ueda, Y | 1 |
| Fuji, N | 1 |
| Itoh, T | 1 |
| Kurioka, H | 1 |
| Shirasaka, T | 4 |
| Yamagishi, H | 1 |
| Okuyama, S | 1 |
| Mishina, H | 1 |
| Ohyama, K | 1 |
| Koike, D | 1 |
| Odake, Y | 1 |
| Takiyama, Y | 1 |
| Saitoh, T | 1 |
| Kagaya, T | 1 |
| Takebe, T | 1 |
| Ishii, K | 1 |
| Ishibashi, S | 1 |
| Iwasa, H | 1 |
| Mimura, K | 1 |
| Ohsaki, Y | 1 |
| Kanabe, S | 1 |
| Hiraide, H | 1 |
| Mizoguchi, O | 1 |
| Tamaki, K | 1 |
| Kurokawa, T | 1 |
| Hatsuse, K | 1 |
| Kadota, T | 1 |
| Ezoe, I | 1 |
| Tsuru, S | 3 |
| Zinnaka, Y | 1 |
| Fujii, S | 4 |
| Syrkin, AB | 1 |
| Voronia, TA | 1 |
| Mikhaĭlova, LM | 1 |
| Suslov, NI | 1 |
| Taguchi, T | 4 |
| Fujita, M | 1 |
| Hayata, S | 1 |
| Narisawa, T | 1 |
| Tani, M | 1 |
| Takahashi, T | 1 |
| Umeno, Y | 1 |
| Yoshida, K | 1 |
| Nagamachi, M | 1 |
| Minami, Y | 1 |
| Sakurai, Y | 1 |
| Fichtner, I | 1 |
| Arnold, W | 1 |
| Naundorf, H | 1 |
| Kawaguchi, Y | 2 |
| Nagayama, S | 1 |
| Masuda, H | 1 |
| Yasuda, A | 1 |
| Arakawa, M | 1 |
| Shimizu, F | 1 |
| Sasagawa, K | 1 |
| Inomata, T | 1 |
| Shinkai, K | 1 |
| Wagner, I | 1 |
| Habs, M | 1 |
| Schmähl, D | 1 |
| Amberger, H | 1 |
| Bachmann, U | 1 |
| Hamada, S | 1 |
| Okajima, E | 1 |
| Hiramatsu, T | 1 |
| Kihoin, K | 1 |
| Ijuin, M | 1 |
| Hirao, Y | 1 |
| Ohara, S | 1 |
| Babaya, K | 1 |
| Tanaka, M | 1 |
| Maruyama, Y | 1 |
| Fujioka, A | 2 |
| Saito, H | 2 |
| Uchida, J | 3 |
| Nakano, K | 3 |
| Takeda, S | 3 |
| Satake, H | 1 |
| Shimamoto, Y | 1 |
| Kato, T | 2 |
| Takechi, T | 2 |
| Okabe, H | 2 |
| Ohshimo, H | 1 |
| Toide, H | 1 |
| Akiyoshi, H | 1 |
| Minato, Y | 1 |
| Okuda, H | 1 |
| Carter, SK | 1 |
| Slavik, M | 1 |
| Borisov, VI | 1 |
| Drago, JR | 1 |
| Maurer, RE | 1 |
| Goldman, LB | 1 |
| Gershwin, ME | 1 |
| Kaneda, T | 1 |
| Ichikawa, H | 1 |
| Hiraiwa, K | 1 |
| Volgareva, GM | 1 |
| Sokova, OI | 1 |
| Pogosiants, EE | 1 |
| Kinami, Y | 1 |
| Odagiri, S | 1 |
| Shinmura, K | 1 |
| Miyazaki, H | 1 |
| Kitano, S | 1 |
| Ikenaka, K | 1 |
| Garibjanian, BT | 1 |
| Johnson, RK | 1 |
| Kline, I | 1 |
| Vadlamudi, S | 1 |
| Gang, M | 1 |
| Venditti, JM | 1 |
| Goldin, A | 1 |
| Baumanis, EA | 1 |
| Kalnina, IE | 1 |
| Brusovanik, VI | 1 |
| Iablonovskaia, LIa | 1 |
| Khlopushina, TG | 1 |
| Krinskaia, AV | 1 |
| Bukhman, VM | 1 |
| Zherdev, VP | 1 |
| Val'dman, AV | 1 |
| Chihara, G | 1 |
| Sakamoto, O | 1 |
| Mori, H | 1 |
| Kitaichi, K | 1 |
| Koda, A | 1 |
| Emi, Y | 1 |
| Kohnoe, S | 1 |
| Yoshida, M | 1 |
| Takahashi, I | 1 |
| Maehara, Y | 1 |
| Sugimachi, K | 1 |
| Shinomiya, N | 1 |
| Katsura, Y | 1 |
| Gotoh, M | 1 |
| Noritake, M | 1 |
| Nomoto, K | 2 |
| Oie, S | 1 |
| Prior, MJ | 1 |
| Maxwell, RJ | 1 |
| Griffiths, JR | 1 |
| Uehara, N | 1 |
| Baba, H | 1 |
| Nitta, K | 1 |
| Kunimoto, T | 1 |
| Takeuchi, M | 1 |
| Sasaki, T | 1 |
| Tanaka, T | 1 |
| Miwa, M | 1 |
| Eda, H | 1 |
| Fukuda, H | 1 |
| Fujimoto, K | 1 |
| Ishitsuka, H | 1 |
| Nio, Y | 2 |
| Ohgaki, K | 2 |
| Tsuchitani, T | 1 |
| Tobe, T | 2 |
| Iigo, M | 1 |
| Yamaizumi, Z | 1 |
| Nishimura, S | 1 |
| Hoshi, A | 1 |
| De Clercq, E | 1 |
| Imai, S | 1 |
| Togami, M | 1 |
| Taniguchi, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase I, Open-Label, Non-Randomized, Dose-Escalating Safety, Tolerability and Pharmacokinetic Study of TAS-114 in Combination With S-1 in Patients With Advanced Solid Tumors[NCT02454062] | Phase 1 | 120 participants (Actual) | Interventional | 2013-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for tegafur and Experimental Neoplasms
| Article | Year |
|---|---|
Studies of analogs of fluorinated pyrimidine in Japan.
Topics: Animals; Antineoplastic Agents; Drug Evaluation, Preclinical; Drug Therapy, Combination; Fluorouraci | 1981 |
[Development of fluorinated pyrimidines in Japan].
Topics: Animals; Antineoplastic Agents; Clinical Trials as Topic; Deoxycytidine; Drug Combinations; Fluorode | 1993 |
Investigational drugs under study by the United States National Cancer Institute.
Topics: Acrylates; Alkylating Agents; Ancitabine; Animals; Antibiotics, Antineoplastic; Antimetabolites, Ant | 1976 |
Soviet antitumor preparations.
Topics: Animals; Antineoplastic Agents; Aziridines; Butylated Hydroxytoluene; Dactinomycin; Daunorubicin; Hu | 1977 |
Recent progress in immunopharmacology and therapeutic effects of polysaccharides.
Topics: Acquired Immunodeficiency Syndrome; Adjuvants, Immunologic; Animals; Drug Screening Assays, Antitumo | 1992 |
1 trial available for tegafur and Experimental Neoplasms
| Article | Year |
|---|---|
Recent progress in immunopharmacology and therapeutic effects of polysaccharides.
Topics: Acquired Immunodeficiency Syndrome; Adjuvants, Immunologic; Animals; Drug Screening Assays, Antitumo | 1992 |
50 other studies available for tegafur and Experimental Neoplasms
| Article | Year |
|---|---|
Studies of antitumor agents. 1. Resolution of racemic 1-(tetrahydro-2-furanyl)-k-fluorouracil into the R and S isomers and examination of the biological activities of the isomers.
Topics: Animals; Bacteria; Fluorouracil; In Vitro Techniques; Male; Mice; Microsomes, Liver; Neoplasms, Expe | 1977 |
Studies on antitumor agents, 2. Syntheses and antitumor activities of 1-(tetrahydro-2-furanyl)-5-fluorouracil and 1,3-bis(tetrahydro-2-furanyl)-5-fluorouracil.
Topics: Animals; Antineoplastic Agents; Carcinoma 256, Walker; Carcinoma, Ehrlich Tumor; Fluorouracil; Letha | 1978 |
(o- and p-Nitrobenzyloxycarbonyl)-5-fluorouracil derivatives as potential conjugated bioreductive alkylating agents.
Topics: Animals; Cells, Cultured; Chemical Phenomena; Chemistry; Fluorouracil; Leukemia P388; Mice; Neoplasm | 1986 |
Synthesis and biological evaluation of novel pyrimidine nucleoside analogues of 1,4-oxathiane, 1,4-dithiane, and 1,4-dioxane.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Chemical Phenomena; Chemistry; Fluorouracil; Hetero | 1982 |
Studies on the synthesis of chemotherapeutics. 12. Synthesis and antitumor activity of N-phthalidyl-5-fluorouracil derivatives.
Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Female; Fluorouracil; Lethal Dose 50; | 1982 |
Studies on the synthesis of chemotherapeutics. 10. Synthesis and antitumor activity of N-acyl- and N-(alkoxycarbonyl)-5-fluorouracil derivatives.
Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Female; Fluorouracil; Lethal Dose 50; | 1980 |
A new sulfated triterpene glycoside from the sea cucumber Colochirus quadrangularis, and evaluation of its antifungal, antitumor and immunomodulatory activities.
Topics: Animals; Antifungal Agents; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Glycosides; Huma | 2021 |
Association between reversal of multidrug resistance by methyl jasmonate and P-glycoprotein ATPase activity in hepatocellular carcinoma.
Topics: Acetates; Adenosine Triphosphate; Animals; Antineoplastic Agents; Antineoplastic Combined Chemothera | 2013 |
Inhibition of metastasis of tumor cells overexpressing thymidine phosphorylase by 2-deoxy-L-ribose.
Topics: Animals; Apoptosis; Deoxyribose; Drug Therapy, Combination; Interleukin-8; Liver Neoplasms; Male; Mi | 2004 |
[Anti-tumor effect of intratumoral administration of dendritic cells in combination with TS-1 and OK-432].
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Dendritic Cells; Drug Combinations; | 2004 |
Dendritic cells might be one of key factors for eliciting antitumor effect by chemoimmunotherapy in vivo.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Combi | 2005 |
Potassium oxonate, an enzyme inhibitor compounded in S-1, reduces the suppression of antitumor immunity induced by 5-fluorouracil.
Topics: Animals; Drug Combinations; Enzyme Inhibitors; Fluorouracil; Immunophenotyping; Interleukin-2; Kille | 2006 |
Consecutive, multimodal therapy of cancer: selective biological initiation (OK-432), cytoplasmic and nuclear damage (FT-207 and cyclophosphamide), inhibition of repair (bleomycin), and activation of cleansing and surveillance mechanisms.
Topics: Animals; Antineoplastic Agents; Biological Products; Bleomycin; Cyclophosphamide; Cytoplasm; DNA Rep | 1981 |
[Antineoplastic effect of UFT therapy (uracil-FT-207 combination therapy) on experimental pancreatic cancer transplanted in the pancreas and subcutaneous region].
Topics: Animals; Antineoplastic Agents; Carcinoma, Intraductal, Noninfiltrating; Cricetinae; Drug Therapy, C | 1982 |
[Experimental studies on the enhancing effects of the combined therapy with tegafur and cytochrome C].
Topics: Animals; Carbon Tetrachloride Poisoning; Cytochrome c Group; Drug Synergism; Drug Therapy, Combinati | 1983 |
[Effect of solcoseryl and combined therapy of solcoseryl and FT-207 for mice bearing meth-A tumor].
Topics: Actihaemyl; Animals; Drug Therapy, Combination; Fluorouracil; Methylcholanthrene; Mice; Mice, Inbred | 1983 |
[Regulation of enzyme activities involved in pyrimidine synthesis and its application to cancer chemotherapy].
Topics: Administration, Oral; Animals; Deoxyuridine; Dihydrouracil Dehydrogenase (NAD+); DNA, Neoplasm; Drug | 1984 |
[Pharmacological compatibility of the antineoplastic drugs ftorafur and 5-fluorouracil with the psychotropic drugs aminazine and phenazepam (an experimental study)].
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Chlorpromazine; Drug Interactions; | 1984 |
Review of a new antimetabolic agent, 1,3-bis(tetrahydro-2-furanyl)-5-fluoro-2,4-pyrimidinedione (FD-1).
Topics: Adult; Aged; Animals; Antimetabolites, Antineoplastic; Delayed-Action Preparations; Dogs; Drug Evalu | 1980 |
Relationship of chemotherapy on human cancer xenografts in nude mice to clinical response in donor patient.
Topics: Adult; Animals; Cytarabine; Drug Resistance; Drug Therapy, Combination; Female; Fluorouracil; Humans | 1980 |
Chemoprevention of development of colonic adenomatosis and carcinomatosis with 5-fluorouracil and ftorafur on animal model.
Topics: Adenoma; Animals; Carcinoma; Colon; Colonic Neoplasms; Female; Fluorouracil; Methylnitrosourea; Neop | 1980 |
High-pressure liquid chromatographic determination of ftorafur [1-(tetrahydro-2-furanyl)-5-fluorouracil] and GLC-mass spectrometric determination of 5-fluorouracil and uracil in biological materials after oral administration of uracil plus ftorafur.
Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Fluorouracil; Gas Chromatograph | 1980 |
Toxicologic and therapeutic examinations with ftorafur in different mouse strains.
Topics: Animals; Female; Fluorouracil; Male; Mice; Mice, Nude; Neoplasms, Experimental; Sex Factors; Tegafur | 1981 |
Studies on the metabolism of 1-(2-tetrahydrofuryl)-5-fluorouracil and uracil co-administered orally to tumor-bearing rats.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Drug Combinations; Fluorouracil; Intestinal Ab | 1980 |
Antitumor activity of methyl (5-fluoro-1H-2-oxo-4-pyrimidinyl beta-D-glucopyranosid)uronate against various experimental tumors.
Topics: Animals; Antineoplastic Agents; Carcinoma; Carcinoma 256, Walker; Female; Fluorouracil; Lung Neoplas | 1981 |
Chemotherapeutic studies on N-nitrosoacetoxymethyl-methylamine-and 1,2-dimethylhydrazine-induced colonic tumors in rats: monotherapy with 5-fluorouracil, ftorafur, CGP 6809, and CGP 15'720A.
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Agents; Carcinogens; Colonic Neoplasms; Dimethylhydra | 1982 |
[Anticancer effect of levamisole and tegafur on 1,2-dimethylhydrazine (DMH)-induced colonic cancers in rats].
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Agents; Colonic Neoplasms; Dimethylhydrazines; Fluoro | 1982 |
[Effect of FT-207 on bladder cancer in rats induced by BBN. II: The effect of oral administration of FT-207 during oncogenesis of bladder cancer].
Topics: Administration, Oral; Animals; Antineoplastic Agents; Body Weight; Butylhydroxybutylnitrosamine; Flu | 1982 |
Prolongation of survival period and improvement of cancer cachexia by long-term administration of UFT.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cachexia; Dogs; Drug Administration Schedul | 1996 |
Preclinical antitumor efficacy of S-1: a new oral formulation of 5-fluorouracil on human tumor xenografts.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Drug Combinations; Fluorouracil; Hum | 1998 |
Comparative studies on the metabolism of 2-(tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil.
Topics: Alanine; Animals; DNA, Neoplasm; Fluorouracil; In Vitro Techniques; Male; Mice; Microsomes, Liver; N | 1977 |
Immunobiology and therapeutic manipulation of heterotransplanted Nb rat prostatic adenocarcinoma. Chemotherapy of autonomous tumor, 102 Pr, heterotransplanted into congenitally athymic (nude) mice and syngeneic Nb rats.
Topics: Adenocarcinoma; Animals; Fluorouracil; Male; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, | 1979 |
[Experimental study relating to the anti-cancer effect of FT-207 suppository (author's transl)].
Topics: Animals; Carcinoma, Squamous Cell; Female; Fluorouracil; Methylcholanthrene; Mice; Neoplasms, Experi | 1979 |
[Action of ftorafur on the chromosomes of normal and tumorous cells of the Djzungarian hamster in vitro].
Topics: Animals; Cell Line; Cells, Cultured; Chromatids; Chromosomes; Cricetinae; Fluorouracil; In Vitro Tec | 1978 |
[Experimental study on the effects of local administration of anticancer drug to the regional lymph nodes (author's transl)].
Topics: Administration, Topical; Animals; Antineoplastic Agents; Dogs; Fluorouracil; Lymph Nodes; Neoplasms, | 1978 |
Effect of coadministration of uracil or cytosine on the anti-tumor activity of clinical doses of 1-(2-tetrahydrofuryl)-5-fluorouracil and level of 5-fluorouracil in rodents.
Topics: Administration, Oral; Animals; Cytosine; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Li | 1979 |
Comparison of 5-fluorouracil and ftorafur. II. Therapeutic response and development of resistance in murine tumors.
Topics: Animals; Carcinoma; Cell Line; Drug Resistance; Drug Therapy, Combination; Female; Fluorouracil; Leu | 1976 |
[Comparative study of the effect of inhibitors of monoamine oxidase and ftorafur on the growth of de-differentiated astrocytoma].
Topics: Animals; Astrocytoma; Cerebellar Neoplasms; Drug Evaluation; Fluorouracil; Monoamine Oxidase Inhibit | 1976 |
[Biochemical bases of ftorafur-potentiating effects of perfluorodecalin, inducer of cytochrome P-450 dependent microsomal monooxygenases].
Topics: Animals; Blood Substitutes; Cytochrome P-450 Enzyme System; Enzyme Induction; Fluorocarbons; Liver N | 1992 |
Antitumor activity of two novel low immunosuppressive fluoropyrimidines UK-21 and UK-25.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Body Weight; Fluorouracil; Glycine; Leukemia L | 1992 |
Hyperthermia enhances the inhibition of tumor growth by 1-(2-tetrahydrofuryl)-5-fluorouracil/uracil (1:4) in tumors in mice and humans.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Combined Modality Therapy; D | 1992 |
Effects of combined therapies with protein-bound polysaccharide (PSK, Krestin) and fluorinated pyrimidine derivatives on experimental liver metastases and on the immunologic capacities of the hosts.
Topics: Adjuvants, Immunologic; Animals; Antibody Formation; Antineoplastic Combined Chemotherapy Protocols; | 1991 |
[Combination chemotherapy with orally administered UFT and leucovorin (LV)].
Topics: Adenocarcinoma; Administration, Oral; Animals; Antineoplastic Agents; Antineoplastic Combined Chemot | 1991 |
In vivo 19F NMR spectroscopy of the antimetabolite 5-fluorouracil and its analogues. An assessment of drug metabolism.
Topics: Animals; Antineoplastic Agents; beta-Alanine; Carcinoid Tumor; Female; Floxuridine; Fluorouracil; In | 1990 |
The therapeutic effects of orally administered 5'-deoxy-5-fluorouridine, 1-(2-tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil on experimental murine tumors.
Topics: Animals; Antineoplastic Agents; Floxuridine; Fluorouracil; Leukemia L1210; Mice; Neoplasms, Experime | 1985 |
[Comparative studies on the antitumor activity of the fluorinated pyrimidines 5'-DFUR, tegafur, UFT and FUra on various murine tumors].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Floxuridine; Fluorouraci | 1988 |
[Cancer chemotherapy against human tumor cell lines transplanted in nude mice. 1. The effect of a new anti-cancer agent, UFT].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line; Male; Mice; Mice, Nude; Neoplasm | 1986 |
The antitumor potency of oral tegafur against adenocarcinoma 755 in mice is markedly enhanced by oral (E)-5-(2-bromovinyl)-2'-deoxyuridine.
Topics: Adenocarcinoma; Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Bromo | 1987 |
[N1-(2-tetrahydrofuryl)-5-fluorouracil (FT-207) is metabolized and converted to 5-fluorouracil in tumor cells].
Topics: Animals; Cells, Cultured; DNA, Neoplasm; Fluorouracil; Mice; Mice, Inbred BALB C; Neoplasms, Experim | 1987 |
[Effects of UFT on experimental liver metastases and on the immunologic capacity of the hosts].
Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Female; Immune Tolera | 1988 |