Page last updated: 2024-11-04

tegafur and Diarrhea

tegafur has been researched along with Diarrhea in 81 studies

Diarrhea: An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.

Research Excerpts

ExcerptRelevanceReference
"The aim of this single-arm phase II clinical trial was to evaluate whether the alternate-day administration of S-1 plus irinotecan would reduce the incidence of severe diarrhea in comparison to consecutive-day S-1 administration (standard IRIS regimen) in second-line treatment for patients with metastatic colorectal cancer."9.27A phase II study of bevacizumab and irinotecan plus alternate-day S-1 as a second-line therapy in patients with metastatic colorectal cancer: the AIRS study. ( Honda, M; Kim, HM; Kondo, K; Kosugi, C; Matsuda, C; Mishima, H; Oba, K; Sakamoto, J; Takahashi, T; Takemoto, H; Tanaka, C; Tokunaga, Y, 2018)
"Gemcitabine (GEM) plus cisplatin (CDDP) chemotherapy has been used worldwide as the standard first-line treatment for advanced biliary tract cancer (BTC)."9.24A Multicenter Phase II Study of Gemcitabine plus S-1 Chemotherapy for Advanced Biliary Tract Cancer. ( Arima, S; Furuse, J; Kasuga, A; Kawai, K; Kitamura, H; Kobayashi, T; Nagashima, F; Naruge, D; Okamoto, T; Okano, N; Shimizu, K; Sugiyama, M; Suzuki, Y; Takasu, A; Toki, M, 2017)
"In Japan, a study comparing the effectiveness and safety of irinotecan plus S-1 (IRIS) with those of a combination of 5-fluorouracil, leucovorin, and irinotecan (FOLFIRI) as second-line treatment in patients with advanced or recurrent colorectal cancer demonstrated that IRIS was non-inferior to FOLFIRI."9.16Phase II study of combined chemotherapy with irinotecan and S-1 (IRIS) plus bevacizumab in patients with inoperable recurrent or advanced colorectal cancer. ( Fukushima, H; Hatanaka, K; Iwanaga, I; Kobayashi, Y; Komatsu, Y; Kudo, M; Meguro, T; Miyagishima, T; Munakata, M; Nakamura, M; Nakatsumi, H; Sakata, Y; Sogabe, S; Tateyama, M; Yuki, S, 2012)
"Sorafenib, a multi-kinase inhibitor with anti-angiogenic activity, was recently approved for the treatment of advanced hepatocellular carcinoma (HCC)."9.14Phase II study of combining sorafenib with metronomic tegafur/uracil for advanced hepatocellular carcinoma. ( Chen, PJ; Cheng, AL; Ding, YH; Hsu, C; Hsu, CH; Lin, ZZ; Shao, YY; Shen, YC, 2010)
"This phase II trial was performed to evaluate the efficacy and tolerability of a new combination of Uracil/Ftorafur (UFT)/leucovorin (LV) and oxaliplatin in patients (pts) with metastatic colorectal cancer (MCRC) who had not received prior chemotherapy for metastatic disease."9.12'A phase II study of oral uracil/ftorafur (UFT) plus leucovorin combined with oxaliplatin (TEGAFOX) as first-line treatment in patients with metastatic colorectal cancer'. ( Bennouna, J; Bordenave, S; Cvitkovic, F; Dorval, E; Douillard, JY; Hebbar, M; Jacob, JH; Malek, K; Paillot, B; Perrier, H; Priou, F; Seitz, JF; Tonelli, D, 2006)
"A combination of irinotecan with continuous intravenous infusions of 5-fluorouracil (5-FU) and leucovorin (LV) is often used to treat advanced colorectal cancer."9.12Phase II study of combination therapy with S-1 and irinotecan in patients with advanced colorectal cancer. ( Goto, A; Hamaguchi, T; Kato, K; Muro, K; Shimada, Y; Shirao, K; Yamada, Y; Yasui, H, 2006)
"A total of 41 metastatic colorectal cancer (CRC) patients received tegafur/uracil (UFT)+leucovorin (LV)+oxaliplatin alternated with UFT/LV+irinotecan."9.11UFT/leucovorin and oxaliplatin alternated with UFT/leucovorin and irinotecan in metastatic colorectal cancer. ( Civitelli, S; Correale, P; De Martino, A; Fiaschi, AI; Francini, G; Giorgi, G; Lorenzi, M; Marsili, S; Marzocca, G; Messinese, S; Petrioli, R; Pozzessere, D; Sabatino, M; Tani, F; Tanzini, G, 2004)
"Low dose oral Folinic acid was used together with uracil with ftorafur (UFT) producing some response with low toxicity in advanced colorectal cancer."9.09Uracil with ftorafur and low dose oral folinic acid in advanced colorectal cancer. ( Arch-Yaemsuan, P; Boonnuch, W; Chakrapee-Sirisuk, S; Lert-Akayamanee, N; Lohsiriwat, D; Nimmanwudipong, T; Sinlarat, P; Srimuninnimit, V; Vathanophas, V, 2001)
"Both the biochemical modulation and the continuous administration of 5-fluorouracil (5-FU) have achieved promising results in patients with gastric carcinoma."9.08Treatment of patients with advanced gastric carcinoma with the combination of etoposide plus oral tegafur modulated by uracil and leucovorin. A phase II study of the ONCOPAZ Cooperative Group. ( Belón, J; Blanco, E; Espinosa, E; Feliu, J; García-Alfonso, P; García-Girón, C; Garrido, P; Gómez-Navarro, J; González Barón, M; Ordónez, A; Zamora, P, 1996)
"A significant response rate with oral tegafur and folinic acid in patients with heavily pretreated breast cancer was found."9.08Phase II trial of an all-oral regimen of tegafur and folinic acid in patients with previously treated metastatic breast cancer. ( Albanell, J; Bellmunt, J; Carulla, J; Gallego, OS; Ribas, A; Solé, LA, 1995)
"The aim of this study was to evaluate systematically the efficacy and safety of oral uracil-tegafur (UFT) plus leucovorin (LV) compared with infusional fluorouracil (5-FU) plus LV for advanced colorectal cancer."8.87Oral uracil-tegafur plus leucovorin vs fluorouracil bolus plus leucovorin for advanced colorectal cancer: a meta-analysis of five randomized controlled trials. ( Bin, Q; Cao, Y; Gao, F; Li, J; Liao, C, 2011)
"Gemcitabine has been standard of care in advanced pancreatic adenocarcinomas (PC) for almost two decades."7.88S-1 (Teysuno) and gemcitabine in Caucasian patients with unresectable pancreatic adenocarcinoma. ( Bjerregaard, JK; Ejlsmark, MW; Jensen, HA; Krogh, M; Pfeiffer, P; Schonnemann, KR; Winther, SB, 2018)
"The uracil/tegafur (UFT) plus oral Leucovorin (LV) regimen is one of the standard chemotherapy modalities for colorectal cancer, and has been reported to have fewer side effects."7.73[Efficacy of uracil/tegafur (UFT) plus oral Leucovorin (LV) therapy for colorectal cancer in elderly patients]. ( Hoki, M; Ito, T; Iwamoto, T; Iwase, K; Kanou, T; Mizuno, H; Mizushima, T; Nakamori, Y; Ozawa, H; Souma, Y, 2006)
" In a previous study, the authors demonstrated that the combination of uracil and tegafur (UFT) with leucovorin (LV) was active and well tolerated in patients with advanced colorectal carcinoma (ACC)."7.69Uracil and tegafur modulated with leucovorin: an effective regimen with low toxicity for the treatment of colorectal carcinoma in the elderly. Oncopaz Cooperative Group. ( Colmenarejo, A; de Castro, J; de la Gándara, I; Espinosa, E; Espinosa, J; Feliu, J; Fernández, Y; García Girón, C; González Barón, M; Jalón, JI, 1997)
"A comparative study was performed to evaluate the efficacy and safety of 5'-DFUR and tegafur in recurrent breast cancer."7.67[A comparative study of 5'-DFUR and tegafur in recurrent breast cancer]. ( Abe, O; Ogawa, N; Taguchi, T; Terasawa, T; Tominaga, T; Yoshida, Y, 1985)
") UFT (250 mg/m(2)/day) for 21 days of a 28-day cycle combined with increasing intravenous (i."6.70Phase I trial of weekly irinotecan combined with UFT as second-line treatment for advanced colorectal cancer. ( Alonso, V; Antón, A; Escudero, P; Herrero, A; Isla, MD; Martinez-Trufero, J; Mayordomo, JI; Sáenz, A; Tres, A; Zorrilla, M, 2001)
"The aim of this single-arm phase II clinical trial was to evaluate whether the alternate-day administration of S-1 plus irinotecan would reduce the incidence of severe diarrhea in comparison to consecutive-day S-1 administration (standard IRIS regimen) in second-line treatment for patients with metastatic colorectal cancer."5.27A phase II study of bevacizumab and irinotecan plus alternate-day S-1 as a second-line therapy in patients with metastatic colorectal cancer: the AIRS study. ( Honda, M; Kim, HM; Kondo, K; Kosugi, C; Matsuda, C; Mishima, H; Oba, K; Sakamoto, J; Takahashi, T; Takemoto, H; Tanaka, C; Tokunaga, Y, 2018)
"Gemcitabine (GEM) plus cisplatin (CDDP) chemotherapy has been used worldwide as the standard first-line treatment for advanced biliary tract cancer (BTC)."5.24A Multicenter Phase II Study of Gemcitabine plus S-1 Chemotherapy for Advanced Biliary Tract Cancer. ( Arima, S; Furuse, J; Kasuga, A; Kawai, K; Kitamura, H; Kobayashi, T; Nagashima, F; Naruge, D; Okamoto, T; Okano, N; Shimizu, K; Sugiyama, M; Suzuki, Y; Takasu, A; Toki, M, 2017)
"The incidence of diarrhea during chemotherapy was significantly lower in the S-1 plus lafutidine group than in the group treated with S-1 alone (10% vs."5.19Feasibility study of supportive care using lafutidine, a histamine H2 receptor antagonist, to prevent gastrointestinal toxicity during chemotherapy for gastric cancer. ( Hanazaki, K; Kitagawa, H; Kobayashi, M; Maeda, H; Munekage, E; Namikawa, T, 2014)
"In Japan, a study comparing the effectiveness and safety of irinotecan plus S-1 (IRIS) with those of a combination of 5-fluorouracil, leucovorin, and irinotecan (FOLFIRI) as second-line treatment in patients with advanced or recurrent colorectal cancer demonstrated that IRIS was non-inferior to FOLFIRI."5.16Phase II study of combined chemotherapy with irinotecan and S-1 (IRIS) plus bevacizumab in patients with inoperable recurrent or advanced colorectal cancer. ( Fukushima, H; Hatanaka, K; Iwanaga, I; Kobayashi, Y; Komatsu, Y; Kudo, M; Meguro, T; Miyagishima, T; Munakata, M; Nakamura, M; Nakatsumi, H; Sakata, Y; Sogabe, S; Tateyama, M; Yuki, S, 2012)
"Sorafenib, a multi-kinase inhibitor with anti-angiogenic activity, was recently approved for the treatment of advanced hepatocellular carcinoma (HCC)."5.14Phase II study of combining sorafenib with metronomic tegafur/uracil for advanced hepatocellular carcinoma. ( Chen, PJ; Cheng, AL; Ding, YH; Hsu, C; Hsu, CH; Lin, ZZ; Shao, YY; Shen, YC, 2010)
"A combination of irinotecan with continuous intravenous infusions of 5-fluorouracil (5-FU) and leucovorin (LV) is often used to treat advanced colorectal cancer."5.12Phase II study of combination therapy with S-1 and irinotecan in patients with advanced colorectal cancer. ( Goto, A; Hamaguchi, T; Kato, K; Muro, K; Shimada, Y; Shirao, K; Yamada, Y; Yasui, H, 2006)
"Tegafur is an oral fluorouracil prodrug used in the treatment of colorectal cancer."5.12A clinical pharmacokinetic analysis of tegafur-uracil (UFT) plus leucovorin given in a new twice-daily oral administration schedule. ( Bennouna, J; Cardot, JM; Château, Y; Douillard, JY; Etienne-Grimaldi, MC; François, E; Gamelin, E; Milano, G; Renée, N, 2007)
"This phase II trial was performed to evaluate the efficacy and tolerability of a new combination of Uracil/Ftorafur (UFT)/leucovorin (LV) and oxaliplatin in patients (pts) with metastatic colorectal cancer (MCRC) who had not received prior chemotherapy for metastatic disease."5.12'A phase II study of oral uracil/ftorafur (UFT) plus leucovorin combined with oxaliplatin (TEGAFOX) as first-line treatment in patients with metastatic colorectal cancer'. ( Bennouna, J; Bordenave, S; Cvitkovic, F; Dorval, E; Douillard, JY; Hebbar, M; Jacob, JH; Malek, K; Paillot, B; Perrier, H; Priou, F; Seitz, JF; Tonelli, D, 2006)
"The purpose of this study was to evaluate the efficacy, assessed as response rate, and toxicity of UFT (Tegafur-Uracil) in combination with oxaliplatin as first-line treatment of advanced colorectal cancer (CRC)."5.11Phase II study of UFT and oxaliplatin in first-line treatment of advanced colorectal cancer. ( Antón-Aparicio, L; Aparicio, J; Constela, M; Dorta, FJ; Feliu, J; Fonseca, E; García-Girón, C; Gonzalez-Baron, M; Lomas, M; Vicent, JM, 2004)
"A total of 41 metastatic colorectal cancer (CRC) patients received tegafur/uracil (UFT)+leucovorin (LV)+oxaliplatin alternated with UFT/LV+irinotecan."5.11UFT/leucovorin and oxaliplatin alternated with UFT/leucovorin and irinotecan in metastatic colorectal cancer. ( Civitelli, S; Correale, P; De Martino, A; Fiaschi, AI; Francini, G; Giorgi, G; Lorenzi, M; Marsili, S; Marzocca, G; Messinese, S; Petrioli, R; Pozzessere, D; Sabatino, M; Tani, F; Tanzini, G, 2004)
"Low dose oral Folinic acid was used together with uracil with ftorafur (UFT) producing some response with low toxicity in advanced colorectal cancer."5.09Uracil with ftorafur and low dose oral folinic acid in advanced colorectal cancer. ( Arch-Yaemsuan, P; Boonnuch, W; Chakrapee-Sirisuk, S; Lert-Akayamanee, N; Lohsiriwat, D; Nimmanwudipong, T; Sinlarat, P; Srimuninnimit, V; Vathanophas, V, 2001)
"A significant response rate with oral tegafur and folinic acid in patients with heavily pretreated breast cancer was found."5.08Phase II trial of an all-oral regimen of tegafur and folinic acid in patients with previously treated metastatic breast cancer. ( Albanell, J; Bellmunt, J; Carulla, J; Gallego, OS; Ribas, A; Solé, LA, 1995)
"Both the biochemical modulation and the continuous administration of 5-fluorouracil (5-FU) have achieved promising results in patients with gastric carcinoma."5.08Treatment of patients with advanced gastric carcinoma with the combination of etoposide plus oral tegafur modulated by uracil and leucovorin. A phase II study of the ONCOPAZ Cooperative Group. ( Belón, J; Blanco, E; Espinosa, E; Feliu, J; García-Alfonso, P; García-Girón, C; Garrido, P; Gómez-Navarro, J; González Barón, M; Ordónez, A; Zamora, P, 1996)
"Thirty-nine patients with locally advanced or metastatic gastric carcinoma received oral UFT (tegafur and uracil) plus leucovorin."5.08A phase II trial. Oral UFT and leucovorin in patients with advanced gastric carcinoma. ( Kim, BS; Kim, JG; Kim, JS; Kim, YH; Park, YT; Shin, SW, 1997)
"The aim of this study was to evaluate systematically the efficacy and safety of oral uracil-tegafur (UFT) plus leucovorin (LV) compared with infusional fluorouracil (5-FU) plus LV for advanced colorectal cancer."4.87Oral uracil-tegafur plus leucovorin vs fluorouracil bolus plus leucovorin for advanced colorectal cancer: a meta-analysis of five randomized controlled trials. ( Bin, Q; Cao, Y; Gao, F; Li, J; Liao, C, 2011)
"Gemcitabine has been standard of care in advanced pancreatic adenocarcinomas (PC) for almost two decades."3.88S-1 (Teysuno) and gemcitabine in Caucasian patients with unresectable pancreatic adenocarcinoma. ( Bjerregaard, JK; Ejlsmark, MW; Jensen, HA; Krogh, M; Pfeiffer, P; Schonnemann, KR; Winther, SB, 2018)
"The uracil/tegafur (UFT) plus oral Leucovorin (LV) regimen is one of the standard chemotherapy modalities for colorectal cancer, and has been reported to have fewer side effects."3.73[Efficacy of uracil/tegafur (UFT) plus oral Leucovorin (LV) therapy for colorectal cancer in elderly patients]. ( Hoki, M; Ito, T; Iwamoto, T; Iwase, K; Kanou, T; Mizuno, H; Mizushima, T; Nakamori, Y; Ozawa, H; Souma, Y, 2006)
"Concomitant treatment with 5-fluorouracil (5-FU) and Leucovorin (LV) is positioned as the standard chemotherapy against colorectal cancer."3.72[Home chemotherapy by concomitant UFT + Leucovorin (po.) in postoperative colorectal cancer patients assessed with Dukes D and curability C colorectal cancer]. ( Anazawa, S; Hirai, K; Kawahara, H; Ogawa, M; Sakuyama, T; Sato, K; Takao, Y; Yamazaki, Y; Yokoyama, M, 2004)
" In a previous study, the authors demonstrated that the combination of uracil and tegafur (UFT) with leucovorin (LV) was active and well tolerated in patients with advanced colorectal carcinoma (ACC)."3.69Uracil and tegafur modulated with leucovorin: an effective regimen with low toxicity for the treatment of colorectal carcinoma in the elderly. Oncopaz Cooperative Group. ( Colmenarejo, A; de Castro, J; de la Gándara, I; Espinosa, E; Espinosa, J; Feliu, J; Fernández, Y; García Girón, C; González Barón, M; Jalón, JI, 1997)
"Twenty-four patients with metastatic breast cancer that had progressed after high-dose chemotherapy with peripheral blood progenitor cell (PBPC) support were given intramuscular methotrexate in combination with oral UFT (tegafur and uracil) and oral leucovorin (the MUL regimen)."3.69Preliminary results. UFT/methotrexate/leucovorin for breast Ca patients in progression after HDCT/PBPC support. ( Ayala, F; Casado, A; Diaz-Rubio, E; López-Martin, JA; Martin, M; Nieto, Y; Rodriguez-Lescure, A, 1997)
"A comparative study was performed to evaluate the efficacy and safety of 5'-DFUR and tegafur in recurrent breast cancer."3.67[A comparative study of 5'-DFUR and tegafur in recurrent breast cancer]. ( Abe, O; Ogawa, N; Taguchi, T; Terasawa, T; Tominaga, T; Yoshida, Y, 1985)
"The incidence of oral mucositis was significantly lower in the treatment group (9."2.90A prospective pilot study of an elemental nutritional supplement for prevention of oral mucositis during S-1 adjuvant chemotherapy for gastric cancer. ( Kimura, A; Kogure, N; Kuwano, H; Mochiki, E; Ogata, K; Suzuki, M; Toyomasu, Y; Yanai, M; Yanoma, T, 2019)
"Unresectable advanced hepatocellular carcinoma is a heterogeneous disease, for which sorafenib is the first targeted agent approved for first-line therapy, and treatment options for patients with sorafenib-refractory advanced hepatocellular carcinoma are limited."2.84S-1 versus placebo in patients with sorafenib-refractory advanced hepatocellular carcinoma (S-CUBE): a randomised, double-blind, multicentre, phase 3 trial. ( Date, Y; Fang, X; Furuse, J; Hidaka, H; Ikeda, M; Kaneko, S; Kawazoe, S; Kudo, M; Moriguchi, M; Numata, K; Ohkawa, S; Okusaka, T; Sato, Y; Takeuchi, M; Tanaka, H, 2017)
"Irinotecan was administered on days 1, 8, 22, and 29."2.82A multicenter phase I study of preoperative chemoradiotherapy with S-1 and irinotecan for locally advanced lower rectal cancer (SAMRAI-1). ( Baba, H; Hayakawa, K; Hiraoka, M; Ikushima, H; Kamikonya, N; Kato, D; Nemoto-Murofushi, K; Noda, M; Oya, M; Oya, N; Sakai, Y; Sato, T; Shimada, M; Takeuchi, M; Tomita, N; Watanabe, M; Watanabe, T, 2016)
"This phase I trial of preoperative S-1 in combination with oxaliplatin and radiation for lower rectal cancer with T4 and lateral pelvic lymph node metastasis revealed that the recommended dose of oxaliplatin was 60 mg/m(2) weekly."2.80A phase I trial of preoperative S-1 in combination with oxaliplatin and pelvic radiation for lower rectal cancer with T4 and lateral pelvic lymph node metastasis. ( Fujita, S; Hamaguchi, T; Ito, Y; Kinugasa, Y; Moriya, Y; Noura, S; Ohue, M; Saito, N; Sakai, D; Shimada, Y, 2015)
"Patients with advanced pancreatic cancer who had received no prior chemotherapy were eligible for this study."2.79A phase I trial of gemcitabine, S-1 and LV combination (GSL) therapy in advanced pancreatic cancer. ( Hamada, T; Hirano, K; Ijichi, H; Isayama, H; Kogure, H; Koike, K; Miyabayashi, K; Mizuno, S; Mohri, D; Nakai, Y; Saito, K; Sasaki, T; Tada, M; Takahara, N; Tateishi, K; Yamamoto, K; Yamamoto, N, 2014)
"To evaluate the efficacy and safety of weekly paclitaxel combined with S-1 or fluorouracil in the first line treatment of advanced gastric carcinoma."2.77[A phase II prospective randomized controlled trial of weekly paclitaxel combined with S-1 or fluorouracil for advanced gastric carcinoma]. ( Ba, Y; Deng, T; Guo, ZQ; Hu, CH; Huang, DZ; Meng, JC; Wan, HP; Wang, ML; Xiong, JP; Xu, N; Yan, Z; Yao, Y; Yu, Z; Yu, ZH; Zhang, Y; Zheng, RS; Zhuang, ZX, 2012)
"54 postoperative colorectal cancer patients received the combination therapy of oxaliplatin and S-1 regimen, repeated every 3 weeks, and evaluate the efficacy after 3 cycles."2.76[Efficacy and side effects of combination therapy of oxaliplatin and S-1 for colorectal cancer]. ( Jin, ZM; Zhu, QC, 2011)
"Diarrhea was the most common type of nonhematologic toxicity: 3 patients had Grade 3 diarrhea."2.76A Phase II trial of neoadjuvant preoperative chemoradiotherapy with S-1 plus irinotecan and radiation in patients with locally advanced rectal cancer: clinical feasibility and response rate. ( Hatate, K; Hayakawa, K; Ihara, A; Koizumi, W; Naito, M; Nakamura, T; Okayasu, I; Onosato, W; Ozawa, H; Sato, T; Watanabe, M; Yamashita, K, 2011)
"We developed a combination chemotherapy, comprising weekly dosing of iv cisplatin (days 1 and 8) combined with a fixed dose (70 mg/m2/day) of S-1 (days 1-14) for patients with metastatic gastric cancer."2.72[S-1 combined with weekly dosing of cisplatin for metastatic gastric cancer]. ( Hyodo, I, 2006)
") gemcitabine (GEM) at low dose plus oral chemotherapy with uracil-tegafur (UFT) and cyclophosphamide (CPA) in combination with radiotherapy (RT) against recurrent and advanced pancreatic cancers."2.71Phase II study on low dose gemcitabine plus oral chemotherapy with uracil-tegafur and cyclophosphamide in combination with radiotherapy against recurrent and advanced pancreatic cancer. ( Endo, S; Hashimoto, K; Higami, T; Itakura, M; Koike, M; Maruyama, R; Nio, Y; Tsuji, M; Yamaguchi, K; Yano, S, 2005)
") UFT (250 mg/m(2)/day) for 21 days of a 28-day cycle combined with increasing intravenous (i."2.70Phase I trial of weekly irinotecan combined with UFT as second-line treatment for advanced colorectal cancer. ( Alonso, V; Antón, A; Escudero, P; Herrero, A; Isla, MD; Martinez-Trufero, J; Mayordomo, JI; Sáenz, A; Tres, A; Zorrilla, M, 2001)
" The potential benefit of long bioavailability and oral delivery of UFT compares favorably with continuous infusion regimens without the added morbidity of a catheter and pump."2.69A phase I study of combined UFT plus leucovorin and radiotherapy for pancreatic cancer. ( Bonner, JA; Childs, HA; Newsome, J; Raben, D; Robert, F; Spencer, SA, 2000)
"The main toxicity was diarrhea and oral mucositis."2.68Phase II trial of Oral UFT and leucovorin in advanced gastric carcinoma. ( Cheong, SK; Kim, JS; Kim, YH; Lee, JD; Park, JS; Shin, SW, 1996)
"Gastric cancer is the most chemosensitive adenocarcinoma among digestive neoplasms."2.68The UFT/leucovorin/etoposide regimen for the treatment of advanced gastric cancer. Oncopaz Cooperative Group. ( Belón, J; de Castro, J; Espinosa, E; Feliu, J; García Alfonso, P; García Girón, C; Garrido, P; González Barón, M; Lomas, M; Ordóñez, A; Zamora, P, 1997)
" Intolerance to single dosing was clearly demonstrated, and only the split dosing was advanced to 500 mg/m2/day."2.68Phase I and pharmacokinetic study of oral UFT, a combination of the 5-fluorouracil prodrug tegafur and uracil. ( Chan, KK; Groshen, S; Jeffers, S; Leichman, CG; Leichman, L; Muggia, FM; Spicer, D; Wu, X, 1996)
" After reducing the dosage of S-1, her diarrhea became milder, and she was able to continue S-1 chemotherapy."1.48The Capsule Endoscopy Findings in S-1-induced Enteritis with Severe Diarrhea during Adjuvant Chemotherapy for Gastric Cancer (with Video). ( Goto, M; Harada, S; Higuchi, K; Kodama, K; Kojima, Y; Nouda, S; Ota, K; Ozaki, H; Takeuchi, T, 2018)
"To identify predictive markers for gastric cancer treatment in Chinese patients, we evaluated the association between polymorphisms of the gene encoding cytochrome P450 2A6 (CYP2A6) and outcomes of S-1 plus oxaliplatin (SOX) chemotherapy treatment."1.46CYP2A6 Polymorphisms Associate with Outcomes of S-1 Plus Oxaliplatin Chemotherapy in Chinese Gastric Cancer Patients. ( Hu, S; Shu, C; Song, Y; Sun, YK; Yang, L; Yang, Y; Yuan, X; Zhang, W; Zhou, A; Zou, S, 2017)
"Gemcitabine plus S-1 is a viable treatment alternative to gemcitabine, which is one of the standard treatments in patients with LAPC."1.46Efficacy and safety of gemcitabine plus S-1 in pancreatic cancer: a pooled analysis of individual patient data. ( Furuse, J; Hamada, C; Ikari, T; Imai, S; Isayama, H; Ishii, H; Nakai, Y; Okamura, S; Okusaka, T, 2017)
"In 62 gastric cancer patients treated with S-1 alone, data relating to the occurrence of gastrointestinal toxicity (diarrhea, vomiting, and nausea) and possible contributing factors were retrospectively collected, and logistic regression analysis was performed."1.40Reduction in gastrointestinal toxicity by gastric secretion inhibitors during S-1 monotherapy for patients with gastric cancer. ( Chisaki, Y; Hira, D; Morita, SY; Noda, S; Terada, T; Yano, Y, 2014)
"The chemotherapy regime was 80 mg/m(2) liposome-paclitaxel given on days 1, 8, 15 and 22, combined with S-1 60 mg (body surface area > 1."1.40Effect of the weekly administration of liposome-Paclitaxel combined with s-1 on advanced gastric cancer. ( Chen, L; Chen, Q; Chen, Z; Shen, L; Shen, X; Tao, J; Wang, H; Wang, J; Zhang, Y; Zhu, M; Zhuang, Z, 2014)
"To observe the local control rate, survival time and side effect of three-dimensional conformal radiation therapy combined with Tegafur for postoperative recurrent rectal carcinoma."1.37[Effecacy of three-dimensional conformal radiation therapy combined with Tegafur for postoperative recurrent rectal carcinoma]. ( Li, WL; Liu, XH, 2011)
"Fifty-one patients with metastatic colorectal cancer were enrolled in the study."1.31Oral uracil/ftorafur (UFT) plus leucovorin as first-line chemotherapy and salvage therapy with weekly high-dose 5-fluorouracil/leucovorin for the treatment of metastatic colorectal cancer. ( Chen, JS; Hsu, KC; Tang, R; Wang, JY; Yang, TS, 2002)
" In the CDHP and Oxo treatment groups of rats, the only toxic signs were soft or diarrheal stools on the dosing day."1.29[Oral single-dose toxicity study of a new antineoplastic agent S-1, and its components, CDHP, and Oxo]. ( Hayashi, T; Hirota, T; Irimura, K; Ohmae, S; Tanaka, G, 1996)
"A 60-year-old female patient with gastric cancer and lymph node and liver metastases was treated with a combination of tegafur and uracil (UFT) (375 mg/m2/day) and mitomycin C (MMC) (5 mg/m2 once weekly)."1.29A case of advanced gastric cancer complicated by severe toxicity induced by a combination of tegafur, uracil and mitomycin C, and associated with abnormal pharmacokinetics. ( Boku, N; Ishii, H; Kaneko, K; Kusada, O; Muro, K; Muto, M; Ohkuwa, M; Ohtsu, A; Sasaki, Y; Tajiri, H; Yoshida, S, 1996)
"Tegafur was administered orally in two or three divided doses."1.27Phase I evaluation of oral tegafur. ( Bedikian, AY; Bodey, GP; Burgess, MA; Valdivieso, M, 1983)

Research

Studies (81)

TimeframeStudies, this research(%)All Research%
pre-19903 (3.70)18.7374
1990's23 (28.40)18.2507
2000's24 (29.63)29.6817
2010's30 (37.04)24.3611
2020's1 (1.23)2.80

Authors

AuthorsStudies
Kawakami, K1
Aoyama, T1
Yokokawa, T1
Kobayashi, K1
Takahari, D1
Chin, K1
Ide, T1
Machida, Y1
Yamaguchi, K2
Hama, T1
Hamada, C1
Okusaka, T2
Ikari, T1
Isayama, H2
Furuse, J3
Ishii, H2
Nakai, Y2
Imai, S1
Okamura, S1
Kudo, M2
Moriguchi, M1
Numata, K1
Hidaka, H1
Tanaka, H1
Ikeda, M1
Kawazoe, S1
Ohkawa, S1
Sato, Y2
Kaneko, S1
Takeuchi, M3
Fang, X1
Date, Y1
Li, J2
Xu, R1
Xu, J1
Denda, T1
Ikejiri, K1
Shen, L2
Toh, Y1
Shimada, K1
Kato, T2
Sakai, K1
Yamamoto, M1
Mishima, H2
Wang, J2
Baba, H2
Yang, L1
Zou, S1
Shu, C1
Song, Y1
Sun, YK1
Zhang, W1
Zhou, A1
Yuan, X1
Yang, Y1
Hu, S1
Ota, K1
Takeuchi, T1
Kodama, K1
Ozaki, H1
Harada, S1
Kojima, Y1
Nouda, S1
Goto, M2
Higuchi, K1
Winther, SB2
Bjerregaard, JK1
Schonnemann, KR1
Ejlsmark, MW1
Krogh, M2
Jensen, HA2
Pfeiffer, P4
Matsuda, C1
Honda, M1
Tanaka, C1
Kondo, K1
Takahashi, T1
Kosugi, C1
Tokunaga, Y1
Takemoto, H1
Kim, HM1
Sakamoto, J1
Oba, K1
Toyomasu, Y1
Mochiki, E1
Yanai, M1
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Yanoma, T1
Kimura, A1
Kogure, N1
Ogata, K1
Kuwano, H1
Chen, L1
Chen, Q1
Zhuang, Z1
Zhang, Y2
Tao, J1
Shen, X1
Chen, Z1
Zhu, M1
Wang, H1
Ohue, M1
Hamaguchi, T2
Ito, Y1
Sakai, D1
Noura, S1
Kinugasa, Y1
Fujita, S1
Shimada, Y2
Saito, N1
Moriya, Y1
Nakamura, T2
Yamashita, K2
Sato, T3
Ema, A1
Naito, M2
Watanabe, M4
Chisaki, Y1
Noda, S1
Hira, D1
Morita, SY1
Yano, Y2
Terada, T1
Saito, K1
Sasaki, T1
Takahara, N1
Hamada, T1
Mizuno, S1
Miyabayashi, K1
Yamamoto, K1
Mohri, D1
Kogure, H1
Yamamoto, N1
Hirano, K1
Ijichi, H1
Tateishi, K1
Tada, M1
Koike, K1
Namikawa, T1
Munekage, E1
Maeda, H1
Kitagawa, H1
Kobayashi, M1
Hanazaki, K1
Abdel-Rahman, O1
ElHalawani, H1
Essam-Eldin, S1
Zubcevic, K1
Qvortrup, C1
Vestermark, LW1
Sorbye, H1
Satoi, S1
Yanagimoto, H1
Yamamoto, T1
Ohe, C1
Miyasaka, C1
Uemura, Y1
Hirooka, S1
Yamaki, S1
Ryota, H1
Michiura, T1
Inoue, K1
Matsui, Y1
Tanigawa, N1
Kon, M1
Hayakawa, K2
Tomita, N1
Noda, M1
Kamikonya, N1
Watanabe, T1
Kato, D1
Sakai, Y1
Hiraoka, M1
Shimada, M1
Ikushima, H1
Oya, N1
Oya, M1
Nemoto-Murofushi, K1
Arima, S1
Shimizu, K1
Okamoto, T1
Toki, M1
Suzuki, Y1
Okano, N1
Naruge, D1
Kawai, K1
Kobayashi, T1
Kasuga, A1
Kitamura, H1
Takasu, A1
Nagashima, F1
Sugiyama, M1
Bin, Q1
Liao, C1
Cao, Y1
Gao, F1
Hsu, CH1
Shen, YC1
Lin, ZZ1
Chen, PJ1
Shao, YY1
Ding, YH1
Hsu, C1
Cheng, AL1
Hong, YS1
Lee, JL2
Park, JH1
Kim, JH1
Yoon, SN1
Lim, SB1
Yu, CS1
Kim, MJ1
Jang, SJ1
Lee, JS2
Kim, JC1
Kim, TW2
Tsunoda, A1
Nakao, K1
Ozawa, H2
Hatate, K1
Onosato, W1
Ihara, A1
Koizumi, W1
Okayasu, I1
Chon, HJ1
Rha, SY1
Park, HS1
Shin, SJ1
Kim, HS1
Roh, JK1
Noh, SH1
Chung, HC1
Jeung, HC1
Liu, XH1
Li, WL1
Zhu, QC1
Jin, ZM1
Komatsu, Y2
Yuki, S2
Sogabe, S1
Fukushima, H1
Nakatsumi, H1
Kobayashi, Y1
Iwanaga, I1
Nakamura, M1
Hatanaka, K1
Miyagishima, T2
Munakata, M1
Meguro, T1
Tateyama, M1
Sakata, Y1
Ozgen, Z1
Ozden, S1
Dane, F1
Atasoy, BM1
Akgun, Z1
Yumuk, PF1
Huang, DZ1
Xiong, JP1
Xu, N1
Yan, Z1
Zhuang, ZX1
Yu, Z1
Wan, HP1
Deng, T1
Zheng, RS1
Guo, ZQ1
Hu, CH1
Wang, ML1
Yu, ZH1
Yao, Y1
Meng, JC1
Ba, Y1
Yang, TS1
Wang, JY1
Tang, R1
Hsu, KC1
Chen, JS1
Petrioli, R1
Sabatino, M1
Fiaschi, AI1
Marsili, S1
Pozzessere, D1
Messinese, S1
Correale, P1
Civitelli, S1
Tanzini, G1
Tani, F1
De Martino, A1
Marzocca, G1
Lorenzi, M1
Giorgi, G1
Francini, G1
Saeki, T1
Takashima, S1
Sano, M1
Horikoshi, N1
Miura, S1
Shimizu, S1
Morimoto, K1
Kimura, M1
Taguchi, T4
Sakuyama, T1
Yokoyama, M1
Ogawa, M1
Takao, Y1
Sato, K1
Kawahara, H1
Anazawa, S1
Yamazaki, Y1
Hirai, K1
Feliu, J5
Vicent, JM1
García-Girón, C2
Constela, M1
Fonseca, E1
Aparicio, J1
Lomas, M2
Antón-Aparicio, L1
Dorta, FJ1
Gonzalez-Baron, M2
Suzuki, S1
Harada, N1
Takeo, Y1
Tanaka, S1
Hayashi, T2
Hanyu, F1
Nio, Y1
Hashimoto, K1
Yano, S1
Itakura, M1
Koike, M1
Endo, S1
Tsuji, M1
Higami, T1
Maruyama, R1
Bennouna, J2
Perrier, H1
Paillot, B1
Priou, F1
Jacob, JH1
Hebbar, M1
Bordenave, S1
Seitz, JF1
Cvitkovic, F1
Dorval, E1
Malek, K1
Tonelli, D1
Douillard, JY2
Goto, A1
Yamada, Y1
Yasui, H1
Kato, K1
Muro, K3
Shirao, K1
Inaba, Y1
Yamaura, H1
Shimamoto, H1
Nishiofuku, H1
Oyama, T1
Kanemitsu, Y1
Sawaki, A1
Arai, Y1
Mizushima, T1
Mizuno, H1
Ito, T1
Hoki, M1
Souma, Y1
Iwamoto, T1
Kanou, T1
Nakamori, Y1
Iwase, K1
Hyodo, I1
Asaka, M1
Kang, HJ1
Kang, YK1
Ryu, MH1
Chang, HM1
Sohn, HJ1
Kim, H1
Etienne-Grimaldi, MC1
François, E1
Cardot, JM1
Renée, N1
Gamelin, E1
Château, Y1
Milano, G1
Shien, T1
Shimizu, C1
Akashi-Tanaka, S1
Yonemori, K1
Kohno, T1
Hojo, T1
Ando, M1
Katsumata, N1
Kinoshita, T1
Fujiwara, Y1
Uedo, N1
Narahara, H1
Ishihara, R1
Takiuchi, H1
Fujitani, K1
Hirao, M1
Tsujinaka, T1
Imano, M1
Furukawa, H1
Tsukuma, H1
Bedikian, AY1
Bodey, GP1
Valdivieso, M1
Burgess, MA1
Inokuchi, K1
Hattori, T1
Abe, O2
Ogawa, N2
Saltz, LB1
Leichman, CG2
Young, CW1
Muggia, FM2
Conti, JA1
Spiess, T1
Jeffers, S2
Leichman, LP1
Solé, LA1
Albanell, J1
Bellmunt, J1
Ribas, A1
Gallego, OS1
Carulla, J1
Pazdur, R1
Lassere, Y1
Rhodes, V1
Ajani, JA1
Sugarman, SM1
Patt, YZ1
Jones, DV1
Markowitz, AB1
Abbruzzese, JL1
Bready, B1
Daniels, M1
Díaz-Rubio, E4
Guillem, V1
Montero, JM1
García-Conde, J1
Estapé, J1
Martín, M2
Herranz, C1
Ordoñez, A4
Galán, A1
Manzuik, LV1
Perevodchikova, NI1
Gorbunova, VA1
Singin, AS1
Gerasimova, GS1
Bychkov, MB1
Rustum, YM1
Creaven, PJ1
Espinosa, E4
de Castro, J3
Zamora, P3
Gomez-Navarro, J2
Espinosa, J2
Vilches, Y1
de la Gandara, I2
Kim, YH2
Cheong, SK1
Lee, JD1
Park, JS1
Shin, SW2
Kim, JS2
González Barón, M3
García-Alfonso, P1
Belón, J2
Blanco, E1
Garrido, P2
Boku, N1
Ohtsu, A1
Kaneko, K1
Muto, M1
Ohkuwa, M1
Sasaki, Y1
Tajiri, H1
Yoshida, S1
Kusada, O1
Tanaka, G1
Irimura, K1
Hirota, T1
Ohmae, S1
García Girón, C2
Colmenarejo, A1
Jalón, JI1
Fernández, Y1
Kurokawa, H1
Miura, K1
Yamashita, Y1
Tokudome, S1
Murata, T1
Kajiyama, M1
Abad, A1
Navarro, M1
Sastre, J1
Marcuello, E1
Aranda, E1
Gallén, M1
Fernandez-Martos, C1
Martín, C1
Casado, A1
López-Martin, JA1
Rodriguez-Lescure, A1
Nieto, Y1
Ayala, F1
González-Larriba, JL1
Garcia Carbonero, I1
Sastre Valera, J1
Perez Segura, P1
García Alfonso, P1
Kurihara, M1
Kim, BS1
Park, YT1
Kim, JG1
Shirasaka, T1
Shimamoto, Y1
Fukushima, M1
Yamashita, F1
Tanaka, M1
Fukumori, K1
Ando, E1
Kato, O1
Yamamoto, H1
Fukuda, H1
Kusaba, T1
Tanikawa, K1
Sata, M1
Wu, X1
Spicer, D1
Groshen, S1
Leichman, L1
Chan, KK1
de la Torre, A1
Ramos, S1
Valcárcel, FJ1
Candal, A1
Regueiro, CA1
Romero, J1
Magallón, R1
Salinas, J1
de las Heras, M1
Veiras, C1
Tisaire, JL1
Aragón, G1
Childs, HA1
Spencer, SA1
Raben, D1
Bonner, JA1
Newsome, J1
Robert, F1
Yoshisue, K1
Hironaga, K1
Yamaguchi, S1
Yamamoto, A1
Nagayama, S1
Kawaguchi, Y1
Bokemeyer, C1
Hartmann, JT1
Mayer, F1
Böhlke, I1
Kanz, L1
Von Pawel, J1
Derigs, G1
Schröder, M1
Alonso, V1
Escudero, P1
Zorrilla, M1
Isla, MD1
Herrero, A1
Mayordomo, JI1
Martinez-Trufero, J1
Sáenz, A1
Tres, A1
Antón, A1
Chakrapee-Sirisuk, S1
Sinlarat, P1
Lohsiriwat, D1
Lert-Akayamanee, N1
Nimmanwudipong, T1
Srimuninnimit, V1
Vathanophas, V1
Arch-Yaemsuan, P1
Boonnuch, W1
Adimi, P1
Hansen, F1
Kjaer, M1
Aabo, K1
Keldsen, N1
Sandberg, E1
Jakobsen, A1
Ohyama, M1
Matsumura, M1
Katsuta, K1
Nobori, T1
Matsuyama, H1
Fukami, K1
Kiyota, R1
Yano, H1
Shima, T1
Ogawa, K1
Terasawa, T1
Yoshida, Y1
Tominaga, T1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Phase II Study of Paclitaxel Liposome Plus S-1 as Neoadjuvant Chemotherapy for Advanced Gastric Cancer[NCT02163291]Phase 230 participants (Anticipated)Interventional2013-12-31Not yet recruiting
Feasibility of Switching Fluoropyrimidine Due to Cardiotoxicity in Patients With Solid Tumors: A Retrospective, International and Non-interventional Study[NCT04260269]200 participants (Anticipated)Observational2018-06-01Enrolling by invitation
Phase II Trial of Combination Therapy With Irinotecan, S-1, and Bevacizumab (IRIS/Bev) in Patients With Unresectable or Recurrent Colorectal Cancer[NCT00569790]Phase 253 participants (Actual)Interventional2007-10-31Completed
Phase III Trial of S-1 and Cisplatin (3 Weekly) Versus S-1 and Oxaliplatin Combination Chemotherapy for First Line Treatment of Advanced Gastric Cancer[NCT01671449]Phase 3338 participants (Actual)Interventional2012-12-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for tegafur and Diarrhea

ArticleYear
S-1-based regimens and the risk of oral and gastrointestinal mucosal injury: a meta-analysis with comparison to other fluoropyrimidines.
    Expert opinion on drug safety, 2016, Volume: 15, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Diarrhea; Drug Combinations; Fluorouracil; Humans; I

2016
Oral uracil-tegafur plus leucovorin vs fluorouracil bolus plus leucovorin for advanced colorectal cancer: a meta-analysis of five randomized controlled trials.
    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 2011, Volume: 13, Issue:8

    Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Diarrhea; Fluorouracil; Humans

2011
[Invention of a tumor-selective 5-fluorouracil derivative named S-1 by biochemical modulation of 5-fluorouracil].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1998, Volume: 25, Issue:3

    Topics: Animals; Anorexia; Antimetabolites, Antineoplastic; Diarrhea; Dogs; Drug Combinations; Female; Fluor

1998

Trials

54 trials available for tegafur and Diarrhea

ArticleYear
S-1 versus placebo in patients with sorafenib-refractory advanced hepatocellular carcinoma (S-CUBE): a randomised, double-blind, multicentre, phase 3 trial.
    The lancet. Gastroenterology & hepatology, 2017, Volume: 2, Issue:6

    Topics: Aged; Antimetabolites, Antineoplastic; Carcinoma, Hepatocellular; Diarrhea; Double-Blind Method; Dru

2017
Phase II study of S-1 plus leucovorin in patients with metastatic colorectal cancer: Regimen of 1 week on, 1 week off.
    Cancer science, 2017, Volume: 108, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Anorexia; Antineoplastic Combined Chemotherapy Protocols; China; Col

2017
A phase II study of bevacizumab and irinotecan plus alternate-day S-1 as a second-line therapy in patients with metastatic colorectal cancer: the AIRS study.
    Cancer chemotherapy and pharmacology, 2018, Volume: 81, Issue:6

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Colorectal Neoplasms; Diarrhea; D

2018
A prospective pilot study of an elemental nutritional supplement for prevention of oral mucositis during S-1 adjuvant chemotherapy for gastric cancer.
    Surgical oncology, 2019, Volume: 29

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Case-Control Studie

2019
A phase I trial of preoperative S-1 in combination with oxaliplatin and pelvic radiation for lower rectal cancer with T4 and lateral pelvic lymph node metastasis.
    International journal of clinical oncology, 2015, Volume: 20, Issue:2

    Topics: Adenocarcinoma; Adult; Aged; Alanine Transaminase; Antineoplastic Combined Chemotherapy Protocols; A

2015
Neoadjuvant chemoradiation therapy using concurrent S-1 and irinotecan in rectal cancer: impact on long-term clinical outcomes and prognostic factors.
    International journal of radiation oncology, biology, physics, 2014, Jul-01, Volume: 89, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Agranulocytosis; Analysis of Variance; Antineoplastic Combined Chemo

2014
A phase I trial of gemcitabine, S-1 and LV combination (GSL) therapy in advanced pancreatic cancer.
    Cancer chemotherapy and pharmacology, 2014, Volume: 74, Issue:5

    Topics: Aged; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Diarrhea; Dose-Respon

2014
Feasibility study of supportive care using lafutidine, a histamine H2 receptor antagonist, to prevent gastrointestinal toxicity during chemotherapy for gastric cancer.
    Anticancer research, 2014, Volume: 34, Issue:12

    Topics: Acetamides; Adenocarcinoma; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic

2014
Experience with S-1 in older Caucasian patients with metastatic colorectal cancer (mCRC): Findings from an observational chart review.
    Acta oncologica (Stockholm, Sweden), 2016, Volume: 55, Issue:7

    Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Ne

2016
A multicenter phase I study of preoperative chemoradiotherapy with S-1 and irinotecan for locally advanced lower rectal cancer (SAMRAI-1).
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2016, Volume: 120, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemoradiotherapy; Diarrh

2016
A Multicenter Phase II Study of Gemcitabine plus S-1 Chemotherapy for Advanced Biliary Tract Cancer.
    Anticancer research, 2017, Volume: 37, Issue:2

    Topics: Administration, Intravenous; Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Co

2017
Phase II study of combining sorafenib with metronomic tegafur/uracil for advanced hepatocellular carcinoma.
    Journal of hepatology, 2010, Volume: 53, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Benzenesul

2010
Phase I study of preoperative chemoradiation with s-1 and oxaliplatin in patients with locally advanced resectable rectal cancer.
    International journal of radiation oncology, biology, physics, 2011, Mar-01, Volume: 79, Issue:3

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Thera

2011
A Phase II trial of neoadjuvant preoperative chemoradiotherapy with S-1 plus irinotecan and radiation in patients with locally advanced rectal cancer: clinical feasibility and response rate.
    International journal of radiation oncology, biology, physics, 2011, Mar-01, Volume: 79, Issue:3

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols

2011
Salvage chemotherapy of biweekly irinotecan plus S-1 (biweekly IRIS) in previously treated patients with advanced gastric cancer.
    Cancer chemotherapy and pharmacology, 2011, Volume: 68, Issue:4

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Diarrhea; Disease-Free Su

2011
[Efficacy and side effects of combination therapy of oxaliplatin and S-1 for colorectal cancer].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 2011, Volume: 33, Issue:5

    Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Aged; Antineoplastic Combined Chemotherapy Protocols; Colo

2011
Phase II study of combined chemotherapy with irinotecan and S-1 (IRIS) plus bevacizumab in patients with inoperable recurrent or advanced colorectal cancer.
    Acta oncologica (Stockholm, Sweden), 2012, Volume: 51, Issue:7

    Topics: Adenocarcinoma; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antineoplastic Combined

2012
Health-related quality of life during postoperative chemoradiotherapy with oral uracil-tegafur and leucovorin in rectal cancer patients.
    Hepato-gastroenterology, 2013, Volume: 60, Issue:123

    Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemot

2013
[A phase II prospective randomized controlled trial of weekly paclitaxel combined with S-1 or fluorouracil for advanced gastric carcinoma].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 2012, Volume: 34, Issue:11

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Diarrhea;

2012
UFT/leucovorin and oxaliplatin alternated with UFT/leucovorin and irinotecan in metastatic colorectal cancer.
    British journal of cancer, 2004, Jan-26, Volume: 90, Issue:2

    Topics: Administration, Oral; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; C

2004
[A late phase II clinical study of S-1 in patients with progressed, refractory breast cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2004, Volume: 31, Issue:4

    Topics: Adult; Aged; Anorexia; Antimetabolites, Antineoplastic; Breast Neoplasms; Diarrhea; Drug Administrat

2004
Phase II study of UFT and oxaliplatin in first-line treatment of advanced colorectal cancer.
    British journal of cancer, 2004, Nov-15, Volume: 91, Issue:10

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Diarrhea; Drug Ad

2004
Phase II study on low dose gemcitabine plus oral chemotherapy with uracil-tegafur and cyclophosphamide in combination with radiotherapy against recurrent and advanced pancreatic cancer.
    Oncology reports, 2005, Volume: 14, Issue:2

    Topics: Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therap

2005
High-dose radiotherapy and concurrent UFT plus l-leucovorin in locally advanced rectal cancer: a phase I trial.
    Acta oncologica (Stockholm, Sweden), 2005, Volume: 44, Issue:3

    Topics: Adenocarcinoma; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic

2005
'A phase II study of oral uracil/ftorafur (UFT) plus leucovorin combined with oxaliplatin (TEGAFOX) as first-line treatment in patients with metastatic colorectal cancer'.
    British journal of cancer, 2006, Jan-16, Volume: 94, Issue:1

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols

2006
Phase II study of combination therapy with S-1 and irinotecan in patients with advanced colorectal cancer.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2006, Volume: 17, Issue:6

    Topics: Adenocarcinoma; Adult; Aged; Anemia; Anorexia; Antimetabolites, Antineoplastic; Antineoplastic Agent

2006
[S-1 combined with weekly dosing of cisplatin for metastatic gastric cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2006, Volume: 33 Suppl 1

    Topics: Administration, Oral; Adult; Aged; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Cisplat

2006
[Irinotecan plus oral S-1 in patients with advanced gastric cancer-biweekly IRIS regimen].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2006, Volume: 33 Suppl 1

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cap

2006
Phase I/II study of 3-week combination of S-1 and cisplatin chemotherapy for metastatic or recurrent gastric cancer.
    Cancer chemotherapy and pharmacology, 2008, Volume: 61, Issue:5

    Topics: Adult; Aged; Anemia; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Diarrhea;

2008
A clinical pharmacokinetic analysis of tegafur-uracil (UFT) plus leucovorin given in a new twice-daily oral administration schedule.
    Clinical pharmacokinetics, 2007, Volume: 46, Issue:11

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve;

2007
Phase II study of a combination of irinotecan and S-1 in patients with advanced gastric cancer (OGSG0002).
    Oncology, 2007, Volume: 73, Issue:1-2

    Topics: Adult; Aged; Anemia; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplas

2007
Postoperative adjuvant chemotherapy for gastric carcinoma. Analysis of data on 1805 patients followed for 5 years.
    Cancer, 1984, Jun-01, Volume: 53, Issue:11

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Combined Moda

1984
A fixed-ratio combination of uracil and Ftorafur (UFT) with low dose leucovorin. An active oral regimen for advanced colorectal cancer.
    Cancer, 1995, Feb-01, Volume: 75, Issue:3

    Topics: Administration, Oral; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Color

1995
Phase II trial of an all-oral regimen of tegafur and folinic acid in patients with previously treated metastatic breast cancer.
    Cancer, 1995, Feb-01, Volume: 75, Issue:3

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms;

1995
Phase II trial of uracil and tegafur plus oral leucovorin: an effective oral regimen in the treatment of metastatic colorectal carcinoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1994, Volume: 12, Issue:11

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neopla

1994
Phase II trial of UFT activity in pretreated breast cancer patients.
    Japanese journal of clinical oncology, 1993, Volume: 23, Issue:6

    Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; A

1993
Initial clinical experience with oral ftorafur and oral 6R,S leucovorin in advanced colorectal carcinoma.
    European journal of cancer (Oxford, England : 1990), 1993, Volume: 29A, Issue:12

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Diarrhea

1993
Cisplatin and UFT modulated with leucovorin for the treatment of Advanced non-small-cell lung cancer.
    American journal of clinical oncology, 1996, Volume: 19, Issue:2

    Topics: Abdominal Pain; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic

1996
Phase II trial of Oral UFT and leucovorin in advanced gastric carcinoma.
    American journal of clinical oncology, 1996, Volume: 19, Issue:2

    Topics: Administration, Oral; Adult; Aged; Antibiotics, Antineoplastic; Antidotes; Antimetabolites, Antineop

1996
Treatment of patients with advanced gastric carcinoma with the combination of etoposide plus oral tegafur modulated by uracil and leucovorin. A phase II study of the ONCOPAZ Cooperative Group.
    Cancer, 1996, Jul-15, Volume: 78, Issue:2

    Topics: Administration, Oral; Adult; Aged; Ambulatory Care; Anemia; Antidotes; Antimetabolites, Antineoplast

1996
[Evaluation of neo-adjuvant chemotherapy for oral squamous cell carcinoma].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1997, Volume: 24, Issue:10

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Squamous Cell;

1997
A preliminary report of a phase II trial. UFT plus oral folinic acid as therapy for metastatic colorectal cancer in older patients. Spanish Group for the Treatment of Gastrointestinal Tumors (TTd Group).
    Oncology (Williston Park, N.Y.), 1997, Volume: 11, Issue:9 Suppl 10

    Topics: Aged; Aged, 80 and over; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neopl

1997
Neoadjuvant therapy with cisplatin/fluorouracil vs cisplatin/UFT in locally advanced squamous cell head and neck cancer.
    Oncology (Williston Park, N.Y.), 1997, Volume: 11, Issue:9 Suppl 10

    Topics: Adult; Aged; Alopecia; Anemia; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous C

1997
The UFT/leucovorin/etoposide regimen for the treatment of advanced gastric cancer. Oncopaz Cooperative Group.
    Oncology (Williston Park, N.Y.), 1997, Volume: 11, Issue:9 Suppl 10

    Topics: Anemia; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Diarrhea; Drug Combinations; Etop

1997
UFT plus cisplatin for advanced gastric cancer.
    Oncology (Williston Park, N.Y.), 1997, Volume: 11, Issue:9 Suppl 10

    Topics: Adolescent; Adult; Aged; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Diarrh

1997
A phase II trial. Oral UFT and leucovorin in patients with advanced gastric carcinoma.
    Oncology (Williston Park, N.Y.), 1997, Volume: 11, Issue:9 Suppl 10

    Topics: Adult; Aged; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Diarrhea; Drug Co

1997
A crossover study of oral administration of UFT in chronic liver disease: comparison of continuous and intermittent schedules.
    Anti-cancer drugs, 1998, Volume: 9, Issue:5

    Topics: Administration, Oral; Aged; Area Under Curve; Carcinoma, Hepatocellular; Chronic Disease; Cross-Over

1998
Phase I and pharmacokinetic study of oral UFT, a combination of the 5-fluorouracil prodrug tegafur and uracil.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1996, Volume: 2, Issue:9

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Area Under Curve; Cohor

1996
Phase II study of radiochemotherapy with UFT and low-dose oral leucovorin in patients with unresectable rectal cancer.
    International journal of radiation oncology, biology, physics, 1999, Oct-01, Volume: 45, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Antidotes; Antimetabolites, Antineoplastic; Diarrhea; Disease-Free S

1999
A phase I study of combined UFT plus leucovorin and radiotherapy for pancreatic cancer.
    International journal of radiation oncology, biology, physics, 2000, Jul-01, Volume: 47, Issue:4

    Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Dia

2000
UFT/leucovorin plus weekly paclitaxel in the treatment of solid tumors.
    Oncology (Williston Park, N.Y.), 2000, Volume: 14, Issue:10 Suppl 9

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Diarrhea; Dose-Re

2000
Phase I trial of weekly irinotecan combined with UFT as second-line treatment for advanced colorectal cancer.
    European journal of cancer (Oxford, England : 1990), 2001, Volume: 37, Issue:18

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Coh

2001
Uracil with ftorafur and low dose oral folinic acid in advanced colorectal cancer.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2001, Volume: 84, Issue:8

    Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Diarrhea;

2001
Oral fluoropyrimidines in the treatment of advanced colorectal cancer--results of two consecutive phase II trials.
    Acta oncologica (Stockholm, Sweden), 2002, Volume: 41, Issue:2

    Topics: Administration, Oral; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Capecit

2002

Other Studies

24 other studies available for tegafur and Diarrhea

ArticleYear
The Combined Use of 5 or More Drugs Is a Factor Related to Lower Adherence to S-1 in S-1 and Oxaliplatin Treatment for Advanced Gastric Cancer.
    Biological & pharmaceutical bulletin, 2021, Volume: 44, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplast

2021
Efficacy and safety of gemcitabine plus S-1 in pancreatic cancer: a pooled analysis of individual patient data.
    British journal of cancer, 2017, Jun-06, Volume: 116, Issue:12

    Topics: Aftercare; Aged; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials, Phase II as Topic;

2017
CYP2A6 Polymorphisms Associate with Outcomes of S-1 Plus Oxaliplatin Chemotherapy in Chinese Gastric Cancer Patients.
    Genomics, proteomics & bioinformatics, 2017, Volume: 15, Issue:4

    Topics: Adult; Aged; Asian People; China; Cytochrome P-450 CYP2A6; Diarrhea; Drug Combinations; Drug Therapy

2017
The Capsule Endoscopy Findings in S-1-induced Enteritis with Severe Diarrhea during Adjuvant Chemotherapy for Gastric Cancer (with Video).
    Internal medicine (Tokyo, Japan), 2018, Feb-01, Volume: 57, Issue:3

    Topics: Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Capsule Endo

2018
S-1 (Teysuno) and gemcitabine in Caucasian patients with unresectable pancreatic adenocarcinoma.
    Cancer chemotherapy and pharmacology, 2018, Volume: 81, Issue:3

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Coho

2018
Effect of the weekly administration of liposome-Paclitaxel combined with s-1 on advanced gastric cancer.
    Japanese journal of clinical oncology, 2014, Volume: 44, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Diarrhea; Disease-Free Survival; Drug A

2014
Reduction in gastrointestinal toxicity by gastric secretion inhibitors during S-1 monotherapy for patients with gastric cancer.
    Biological & pharmaceutical bulletin, 2014, Volume: 37, Issue:7

    Topics: Aged; Diarrhea; Dose-Response Relationship, Drug; Drug Combinations; Female; Gastric Mucosa; Histami

2014
Clinical outcomes of pancreatic ductal adenocarcinoma resection following neoadjuvant chemoradiation therapy vs. chemotherapy.
    Surgery today, 2017, Volume: 47, Issue:1

    Topics: Adult; Aged; Ascites; Carcinoma, Pancreatic Ductal; Chemoradiotherapy, Adjuvant; Chemotherapy, Adjuv

2017
[Compliance of oral UFT plus leucovorin adjuvant chemotherapy in patients who underwent curative resection for colorectal cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2010, Volume: 37, Issue:6

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anorexia; Antineoplastic Combined Chemotherapy

2010
[Effecacy of three-dimensional conformal radiation therapy combined with Tegafur for postoperative recurrent rectal carcinoma].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 2011, Volume: 33, Issue:4

    Topics: Adenocarcinoma; Adult; Aged; Antimetabolites, Antineoplastic; Combined Modality Therapy; Diarrhea; E

2011
Oral uracil/ftorafur (UFT) plus leucovorin as first-line chemotherapy and salvage therapy with weekly high-dose 5-fluorouracil/leucovorin for the treatment of metastatic colorectal cancer.
    Japanese journal of clinical oncology, 2002, Volume: 32, Issue:9

    Topics: Adult; Aged; Antineoplastic Agents; Colonic Neoplasms; Diarrhea; Dose-Response Relationship, Drug; D

2002
[Home chemotherapy by concomitant UFT + Leucovorin (po.) in postoperative colorectal cancer patients assessed with Dukes D and curability C colorectal cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2004, Volume: 31, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Diarrhea; Drug Administration

2004
[A case of recurrent gallbladder cancer responding to combination chemotherapy of TS-1 and CDDP].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2004, Volume: 31, Issue:10

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Diarrhea

2004
[Retrospective analysis of tegafur/uracil (UFT) plus oral leucovorin (LV) regimen in patients with advanced colorectal cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2006, Volume: 33, Issue:7

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols

2006
[Efficacy of uracil/tegafur (UFT) plus oral Leucovorin (LV) therapy for colorectal cancer in elderly patients].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2006, Volume: 33, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Colorectal

2006
Clinical efficacy of S-1 in pretreated metastatic breast cancer patients.
    Japanese journal of clinical oncology, 2008, Volume: 38, Issue:3

    Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Bone Neoplasms; Breast Neoplasms

2008
Phase I evaluation of oral tegafur.
    Cancer treatment reports, 1983, Volume: 67, Issue:1

    Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Blood Cell Count; Diarrhea; Dose-Response Relatio

1983
A case of advanced gastric cancer complicated by severe toxicity induced by a combination of tegafur, uracil and mitomycin C, and associated with abnormal pharmacokinetics.
    Japanese journal of clinical oncology, 1996, Volume: 26, Issue:5

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Bone Marrow Diseas

1996
[Oral single-dose toxicity study of a new antineoplastic agent S-1, and its components, CDHP, and Oxo].
    The Journal of toxicological sciences, 1996, Volume: 21 Suppl 3

    Topics: Administration, Oral; Alopecia; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Ch

1996
Uracil and tegafur modulated with leucovorin: an effective regimen with low toxicity for the treatment of colorectal carcinoma in the elderly. Oncopaz Cooperative Group.
    Cancer, 1997, May-15, Volume: 79, Issue:10

    Topics: Administration, Oral; Aged; Aged, 80 and over; Ambulatory Care; Antidotes; Antimetabolites, Antineop

1997
Preliminary results. UFT/methotrexate/leucovorin for breast Ca patients in progression after HDCT/PBPC support.
    Oncology (Williston Park, N.Y.), 1997, Volume: 11, Issue:9 Suppl 10

    Topics: Adult; Anemia; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Diarrhea

1997
Reduction of 5-fluorouracil (5-FU) gastrointestinal (GI) toxicity resulting from the protection of thymidylate synthase (TS) in GI tissue by repeated simultaneous administration of potassium oxonate (Oxo) in rats.
    Cancer chemotherapy and pharmacology, 2000, Volume: 46, Issue:1

    Topics: Animals; Antimetabolites, Antineoplastic; Body Weight; Colon; Diarrhea; Digestive System; Drug Combi

2000
[A comparative study of UFT enteric-coated granules with UFT capsules on the occurrence of side effects in patients with head and neck cancers--a special attention to the upper gastrointestinal tract disorders].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1990, Volume: 17, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Capsules; Diarrhea;

1990
[A comparative study of 5'-DFUR and tegafur in recurrent breast cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:10

    Topics: Administration, Oral; Adult; Aged; Anorexia; Antineoplastic Agents; Breast Neoplasms; Capsules; Diar

1985