Page last updated: 2024-11-04

tegafur and Cirrhosis, Liver

tegafur has been researched along with Cirrhosis, Liver in 12 studies

Research Excerpts

ExcerptRelevanceReference
"We report a case of complete remission of multiple hepatocellular carcinomas after oral administration of enteric-coated tegafur/uracil."7.70Complete remission of multiple hepatocellular carcinomas associated with hepatitis C virus-related, decompensated liver cirrhosis by oral administration of enteric-coated tegafur/uracil. ( Asakura, H; Ebe, Y; Ichida, T; Ishikawa, T; Ishimoto, Y; Naito, M; Nomoto, M; Usuda, H; Yokoyama, J, 1999)
"Two female breast cancer patients who received combined tamoxifen and tegafur as postsurgical adjuvant therapy developed severe hepatotoxicity after being treated for three and eight months, respectively."7.69Chronic active hepatitis and liver cirrhosis in association with combined tamoxifen/tegafur adjuvant therapy. ( Abe, J; Hirayama, C; Maruyama, S; Matsui, K; Tanaka, J, 1995)
"The pharmacokinetics of 1-(tetrahydro-2-furanyl)-5-fluorouracil (FT) and its conversion into 5-fluorouracil (FUra) in liver tissue were studied in ten patients with hepatocellular carcinoma (HCC)."7.67Hepatic conversion of 1-(tetrahydro-2-furanyl)-5-fluorouracil into 5-fluorouracil in patients with hepatocellular carcinoma. ( Imai, Y; Kawata, S; Minami, Y; Miyoshi, S; Noda, S; Saitoh, R; Tamura, S; Tarui, S, 1987)
"Pretreatment with tocopheryl nicotinate and indomethacin increased the K values in the control subjects, but was without effect on the K values in patients with primary hepatoma."5.26Decreased disappearance rate of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT-207) from the blood and its unresponsiveness to tocophreyl nicotinate and indomethacin in patients with primary hepatocellular carcinoma. ( Hobara, N; Watanabe, A, 1979)
"We report a case of complete remission of multiple hepatocellular carcinomas after oral administration of enteric-coated tegafur/uracil."3.70Complete remission of multiple hepatocellular carcinomas associated with hepatitis C virus-related, decompensated liver cirrhosis by oral administration of enteric-coated tegafur/uracil. ( Asakura, H; Ebe, Y; Ichida, T; Ishikawa, T; Ishimoto, Y; Naito, M; Nomoto, M; Usuda, H; Yokoyama, J, 1999)
"Two female breast cancer patients who received combined tamoxifen and tegafur as postsurgical adjuvant therapy developed severe hepatotoxicity after being treated for three and eight months, respectively."3.69Chronic active hepatitis and liver cirrhosis in association with combined tamoxifen/tegafur adjuvant therapy. ( Abe, J; Hirayama, C; Maruyama, S; Matsui, K; Tanaka, J, 1995)
"UFT was administered preoperatively in 20 cases of primary hepatocellular carcinoma, and tegafur, 5-fluorouracil (5-FU), uracil, total thymidylate synthase (TS) and free TS in blood and liver tissue were determined."3.67[Study on the pharmacokinetics of UFT in patients with hepatocellular carcinoma associated with cirrhosis]. ( Ito, Y; Matsuoka, S; Misawa, K; Nagafuchi, E; Nakajima, Y; Ogasawara, K; Sato, N; Uchino, J; Une, Y, 1989)
"The pharmacokinetics of 1-(tetrahydro-2-furanyl)-5-fluorouracil (FT) and its conversion into 5-fluorouracil (FUra) in liver tissue were studied in ten patients with hepatocellular carcinoma (HCC)."3.67Hepatic conversion of 1-(tetrahydro-2-furanyl)-5-fluorouracil into 5-fluorouracil in patients with hepatocellular carcinoma. ( Imai, Y; Kawata, S; Minami, Y; Miyoshi, S; Noda, S; Saitoh, R; Tamura, S; Tarui, S, 1987)
"Tegafur fine granule preparation orally administered to the patients with primary hepatoma and liver cirrhosis, and the concentration of tegafur and 5-fluorouracil in the blood were determined."3.66[Sequential changes in blood concentrations of tegafur and 5-FU during oral administration of fine granules of tegafur in patients with primary liver cancer]. ( Hattori, M; Horiike, N; Kanaoka, M; Ohta, Y; Onji, M; Yamashita, Y; Yoshida, T, 1982)
"Tegafur-uracil has been reported to have only minor adverse effects and is associated with liver injury in 1."1.46Tegafur-uracil-induced rapid development of advanced hepatic fibrosis. ( Fujiya, M; Hasebe, T; Honda, S; Nakajima, S; Okumura, T; Sawada, K, 2017)
"A 77-year-old male with liver cirrhosis was admitted to our hospital for further examination and treatment of liver tumor."1.29[A case of hepatocellular carcinoma responding to oral administration of UFT]. ( Matsumoto, K; Onodera, H; Otawa, K; Sato, T; Ukai, K, 1996)
"Pretreatment with tocopheryl nicotinate and indomethacin increased the K values in the control subjects, but was without effect on the K values in patients with primary hepatoma."1.26Decreased disappearance rate of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT-207) from the blood and its unresponsiveness to tocophreyl nicotinate and indomethacin in patients with primary hepatocellular carcinoma. ( Hobara, N; Watanabe, A, 1979)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19906 (50.00)18.7374
1990's3 (25.00)18.2507
2000's2 (16.67)29.6817
2010's1 (8.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Honda, S1
Sawada, K1
Hasebe, T1
Nakajima, S1
Fujiya, M1
Okumura, T1
Onji, M1
Yamashita, Y1
Horiike, N1
Kanaoka, M1
Ohta, Y1
Yoshida, T1
Hattori, M1
Maruyama, S1
Hirayama, C1
Abe, J1
Tanaka, J1
Matsui, K1
Onodera, H1
Ukai, K1
Matsumoto, K1
Otawa, K1
Sato, T2
Ishikawa, T1
Ichida, T1
Ishimoto, Y1
Yokoyama, J1
Nomoto, M1
Ebe, Y1
Usuda, H1
Naito, M1
Asakura, H1
Ono, T1
Yamanoi, A1
Nazmy El Assal, O1
Kohno, H1
Nagasue, N1
Aguayo, A1
Patt, YZ1
Hobara, N1
Watanabe, A1
Une, Y1
Ito, Y1
Ogasawara, K1
Nagafuchi, E1
Matsuoka, S1
Misawa, K1
Sato, N1
Nakajima, Y1
Uchino, J1
Ikeda, K1
Kumada, H1
Arase, Y1
Chayama, K1
Gunji, T1
Yoshiba, A1
Irimoto, M1
Oguma, S1
Sakai, K1
Sato, R1
Ouchi, K1
Owada, Y1
Kawata, S1
Noda, S1
Imai, Y1
Tamura, S1
Saitoh, R1
Miyoshi, S1
Minami, Y1
Tarui, S1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Efficacy and Safety of Donafenib Combined With TACE as Adjuvant Therapy of Patients With Hepatocellular Carcinoma at a High Risk of Recurrence After Radical Resection[NCT05161143]Phase 230 participants (Anticipated)Interventional2021-12-31Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for tegafur and Cirrhosis, Liver

ArticleYear
Adjuvant chemotherapy after resection of hepatocellular carcinoma causes deterioration of long-term prognosis in cirrhotic patients: metaanalysis of three randomized controlled trials.
    Cancer, 2001, Jun-15, Volume: 91, Issue:12

    Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Carcinoma, Hepa

2001
Nonsurgical treatment of hepatocellular carcinoma.
    Seminars in oncology, 2001, Volume: 28, Issue:5

    Topics: Angiogenesis Inhibitors; Antineoplastic Agents; Capecitabine; Carcinoma, Hepatocellular; Chemoemboli

2001

Other Studies

10 other studies available for tegafur and Cirrhosis, Liver

ArticleYear
Tegafur-uracil-induced rapid development of advanced hepatic fibrosis.
    World journal of gastroenterology, 2017, Aug-21, Volume: 23, Issue:31

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Ascites; Biopsy; Carcinoma, Hepatocellular; Di

2017
[Sequential changes in blood concentrations of tegafur and 5-FU during oral administration of fine granules of tegafur in patients with primary liver cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1982, Volume: 9, Issue:3

    Topics: Administration, Oral; Antineoplastic Agents; Carcinoma, Hepatocellular; Female; Fluorouracil; Humans

1982
Chronic active hepatitis and liver cirrhosis in association with combined tamoxifen/tegafur adjuvant therapy.
    Digestive diseases and sciences, 1995, Volume: 40, Issue:12

    Topics: Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Brea

1995
[A case of hepatocellular carcinoma responding to oral administration of UFT].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1996, Volume: 23, Issue:7

    Topics: Administration, Oral; Aged; alpha-Fetoproteins; Biomarkers; Carcinoma, Hepatocellular; Drug Combinat

1996
Complete remission of multiple hepatocellular carcinomas associated with hepatitis C virus-related, decompensated liver cirrhosis by oral administration of enteric-coated tegafur/uracil.
    The American journal of gastroenterology, 1999, Volume: 94, Issue:6

    Topics: Administration, Oral; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Pr

1999
Decreased disappearance rate of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT-207) from the blood and its unresponsiveness to tocophreyl nicotinate and indomethacin in patients with primary hepatocellular carcinoma.
    Acta medica Okayama, 1979, Volume: 33, Issue:5

    Topics: Carcinoma, Hepatocellular; Fluorouracil; Humans; Indomethacin; Kinetics; Liver Cirrhosis; Liver Neop

1979
[Study on the pharmacokinetics of UFT in patients with hepatocellular carcinoma associated with cirrhosis].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1989, Volume: 16, Issue:9

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Female; Fluo

1989
[Risk factors for side effects of long-term administration of 5-fluorouracil derivatives in patients with hepatocellular carcinoma associated with liver cirrhosis--relationship with serum concentration of anti-tumor agents and side effect].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 1988, Volume: 85, Issue:11

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Ascites; Brain Diseases; Carcinoma, Hepatocell

1988
[FT, 5-FU and uracil concentrations of the blood, bile and tissue of hepatoma with liver cirrhosis after oral administration of UFT].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:4

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Bile; Carcinoma, Hepatocellula

1987
Hepatic conversion of 1-(tetrahydro-2-furanyl)-5-fluorouracil into 5-fluorouracil in patients with hepatocellular carcinoma.
    Gastroenterologia Japonica, 1987, Volume: 22, Issue:1

    Topics: Aged; Carcinoma, Hepatocellular; Drug Therapy, Computer-Assisted; Fluorouracil; Humans; In Vitro Tec

1987