tegafur has been researched along with Chemical and Drug Induced Liver Injury in 11 studies
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Following intravenous administration of S-1, the blood concentration-time profiles of CDHP were similar between control rats and rats with hepatic dysfunction, but the half-life of tegafur was significantly prolonged." | 5.35 | Effect of dimethylnitrosamine-induced liver dysfunction on the pharmacokinetics of 5-fluorouracil after administration of S-1, an antitumour drug, to rats. ( Chikamoto, J; Kanie, S; Nagayama, S; Nishimura, T; Yoshisue, K, 2009) |
| " In the present study the therapeutic effect and metabolism of 5-FU and its masked compounds: FT, UFT (uracil + FT), HCFU (Carmofur), 5'-DFUR (Doxifluridine) were assessed by using MOPC-104E plasmacytoma transplanted subcutaneously in BALB/c mice with CCl4-induced chronic liver dysfunction." | 3.68 | [Chemotherapy with fluoropyrimidines for MOPC-104E plasmacytoma transplanted in mice with CCl4 induced chronic liver dysfunction]. ( Imai, S; Morimoto, H; Nio, Y; Shiraishi, T; Tobe, T; Tseng, CC; Tsubono, M, 1990) |
| " Following intravenous administration of S-1, the blood concentration-time profiles of CDHP were similar between control rats and rats with hepatic dysfunction, but the half-life of tegafur was significantly prolonged." | 1.35 | Effect of dimethylnitrosamine-induced liver dysfunction on the pharmacokinetics of 5-fluorouracil after administration of S-1, an antitumour drug, to rats. ( Chikamoto, J; Kanie, S; Nagayama, S; Nishimura, T; Yoshisue, K, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (27.27) | 18.7374 |
| 1990's | 3 (27.27) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Kawasaki, A | 1 |
| Mimatsu, K | 1 |
| Kuboi, Y | 1 |
| Kano, H | 1 |
| Oida, T | 1 |
| Amano, S | 1 |
| Yoshisue, K | 1 |
| Kanie, S | 1 |
| Nishimura, T | 1 |
| Chikamoto, J | 1 |
| Nagayama, S | 1 |
| Sudo, C | 1 |
| Maekawa, K | 1 |
| Segawa, K | 1 |
| Hanatani, T | 1 |
| Sai, K | 1 |
| Saito, Y | 1 |
| Nukaya, H | 1 |
| Hirashima, N | 1 |
| Tanaka, Y | 1 |
| Endo, M | 1 |
| Matsunaga, S | 1 |
| Hasegawa, I | 1 |
| Kato, A | 1 |
| Sakakibara, K | 1 |
| Sakamoto, T | 1 |
| Kondo, H | 1 |
| Kobayashi, F | 1 |
| Ikeda, T | 1 |
| Sakamoto, N | 1 |
| Kurosaki, M | 1 |
| Tozuka, S | 1 |
| Sakamoto, S | 1 |
| Fukuma, T | 1 |
| Marumo, F | 1 |
| Sato, C | 1 |
| Suzuki, K | 1 |
| Nukui, A | 1 |
| Kobayashi, M | 1 |
| Sugaya, Y | 1 |
| Muraishi, O | 1 |
| Morita, T | 1 |
| Tokue, A | 1 |
| Tsubono, M | 1 |
| Nio, Y | 1 |
| Imai, S | 1 |
| Shiraishi, T | 1 |
| Morimoto, H | 1 |
| Tseng, CC | 1 |
| Tobe, T | 1 |
| Seki, S | 1 |
| Mizoguchi, Y | 1 |
| Saito, S | 1 |
| Shiomi, S | 1 |
| Sakagami, Y | 1 |
| Sakaguchi, H | 1 |
| Kuroki, T | 1 |
| Harihara, S | 1 |
| Kobayashi, K | 1 |
| Monna, T | 1 |
| Aoike, A | 1 |
| Hosokawa, T | 1 |
| Koyama, K | 1 |
| Rokutan, K | 1 |
| Nishi, Y | 1 |
| Yoshida, A | 1 |
| Nakamura, K | 1 |
| Kawai, K | 1 |
| Kitamura, M | 1 |
| Tominaga, T | 1 |
| Hayashi, K | 1 |
| Takahashi, I | 1 |
| Kosaki, G | 1 |
2 reviews available for tegafur and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
[An investigation of TS-1 single-agent therapy administered as first-line therapy for unresectable advanced gastric cancer].
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Chemical and Drug Induced Liver Inj | 2005 |
[A case of pulmonary metastasis from renal cell carcinoma with complete response to interferon-alpha and tegafur/uracil (UFT) but possibly UFT-induced liver dysfunction and leukoencephalopathy-like symptoms].
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Carcinoma, Renal Cell; Chemical and | 1999 |
1 trial available for tegafur and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
[Preliminary report of adjuvant chemo-endocrine therapy for breast cancer].
Topics: Adult; Anorexia; Breast Neoplasms; Chemical and Drug Induced Liver Injury; Combined Modality Therapy | 1985 |
8 other studies available for tegafur and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
[Drug-induced liver injury associated with uracil/tegafur + folinate therapy].
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemical and | 2009 |
Effect of dimethylnitrosamine-induced liver dysfunction on the pharmacokinetics of 5-fluorouracil after administration of S-1, an antitumour drug, to rats.
Topics: Animals; Antineoplastic Agents; Area Under Curve; Chemical and Drug Induced Liver Injury; Dihydroura | 2009 |
[Trends in drug-induced liver injury based on reports of adverse reactions to PMDA in Japan].
Topics: Adverse Drug Reaction Reporting Systems; Anti-Infective Agents; Anti-Inflammatory Agents; Antineopla | 2012 |
Severe chronic active hepatitis induced by UFTR containing tegafur and uracil.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; Chemic | 1995 |
[Chemotherapy with fluoropyrimidines for MOPC-104E plasmacytoma transplanted in mice with CCl4 induced chronic liver dysfunction].
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carbon Tetrachloride | 1990 |
[A clinicopathological study of 11 patients with acute drug-induced hepatic failure].
Topics: Acute Disease; Adult; Aged; Chemical and Drug Induced Liver Injury; Ethionamide; Female; Halothane; | 1986 |
[Effect of fluoropyrimidine, drugs of tegafur and UFT on transplanted tumor in liver-damaged mice].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carbon Tetrachloride Poisoning; Chemical an | 1988 |