tedanolide and Melanoma

tedanolide has been researched along with Melanoma* in 1 studies

Other Studies

1 other study(ies) available for tedanolide and Melanoma

Article	Year
New candidaspongiolides, tedanolide analogues that selectively inhibit melanoma cell growth. Organic letters, 2011, Jul-01, Volume: 13, Issue:13 Extracts of the sponge genus Candidaspongia showed selective cytotoxicity toward melanoma cells in the NCI 60-cell-line screen. Continued investigation of the Candidaspongia sp. extracts led to the isolation of three new tedanolide analogues, precandidaspongiolides A (1) and B (2) and candidaspongiolide B (4), as well as candidaspongiolide A (3) and tedanolide (5). Semisynthetic derivatives were also generated to develop SAR. Candidaspongiolides A/B were the most potent and showed low nanomolar activity against several melanoma cell lines. Topics: Cell Line, Tumor; Cell Proliferation; Humans; Macrolides; Melanoma; Structure-Activity Relationship	2011

Article

Year

New candidaspongiolides, tedanolide analogues that selectively inhibit melanoma cell growth.

Organic letters, 2011, Jul-01, Volume: 13, Issue:13

Extracts of the sponge genus Candidaspongia showed selective cytotoxicity toward melanoma cells in the NCI 60-cell-line screen. Continued investigation of the Candidaspongia sp. extracts led to the isolation of three new tedanolide analogues, precandidaspongiolides A (1) and B (2) and candidaspongiolide B (4), as well as candidaspongiolide A (3) and tedanolide (5). Semisynthetic derivatives were also generated to develop SAR. Candidaspongiolides A/B were the most potent and showed low nanomolar activity against several melanoma cell lines.

Topics: Cell Line, Tumor; Cell Proliferation; Humans; Macrolides; Melanoma; Structure-Activity Relationship

2011