technetium-tc-99m-tetrofosmin and Hodgkin-Disease

The purpose of this study was to compare the usefulness of gallium-67 citrate (67Ga) and technetium-99m tetrofosmin (Tc-TF) scan to detect Hodgkin's disease (HD).. In this study, 24 patients with HD underwent 67Ga and Tc-TF scan before receiving any therapy.. 67Ga scan could detect HD in all 24 (100%) patients. Tc-TF scan could detect HD in 22/24 (91.6%) patients, but it was false-negative in one case of infradiaphragmatic HD and in another case with chemotherapy resistance. There was no significant difference in detection sensitivity between 67Ga and Tc-TF scan.. We conclude that Tc-TF scan can not replace conventional 67Ga scan to detect HD.

Topics: Adult; Age Factors; Citrates; False Negative Reactions; Female; Gallium; Hodgkin Disease; Humans; Male; Middle Aged; Organophosphorus Compounds; Organotechnetium Compounds; Radionuclide Imaging; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Sex Factors; Whole-Body Counting

Technetium-99m (99mTc) tetrofosmin has been used as a tumor-seeking agent. However, its role in detecting lymphomas has not been widely investigated. The aim of the present study was to determine the uptake and clearance characteristics of 99mTc tetrofosmin in lymphoma cell lines. 99mTc sestamibi was also evaluated for comparison. Three lymphoma cell lines (U-937: monocyte-like, histiocytic lymphoma, human; RAMOS: B-lymphoma cell line, American Burkitt lymphoma, lymphoblastoid, human; Hs445: Hodgkin's disease, lymphoid, human) were studied. After incubation of radiotracers 99mTc tetrofosmin and 99mTc sestamibi in medium for 0, 10, 20, 30, 60, 120 and 180 min, the uptake and clearance of each radiotracer were measured in the three lymphoma cell lines. The uptake of 99mTc tetrofosmin was lower than that of 99mTc sestamibi in these lymphoma cell lines. Among the three cell lines, Hs445 showed the greatest 99mTc tetrofosmin uptake capacity. RAMOS and U-937 showed similar 99mTc tetrofosmin uptake capacities. 99mTc tetrofosmin accumulated in the three tested lymphoma cell lines, especially in the Hodgkin's disease cell line. However, in comparison with 99mTc sestamibi, 99mTc tetrofosmin may not be the best radiotracer for detection of lymphoma.

Topics: Biological Transport; Hodgkin Disease; Humans; Kinetics; Lymphoma; Lymphoma, B-Cell; Organophosphorus Compounds; Organotechnetium Compounds; Radiopharmaceuticals; Technetium Tc 99m Sestamibi; Tumor Cells, Cultured

The aim of this study was to assess the suitability of 99Tcm-tetrofosmin (tetrofosmin) scintigraphy as a diagnostic modality in patients with Hodgkin's disease. Fourteen untreated patients with biopsy proven Hodgkin's disease (clinical stage Ia-IVb) were investigated. Post-treatment investigations were also done in 7 of the 14 patients. Focal pathological tetrofosmin uptake was seen in 42 site in the pre-treatment studies. Computed tomography identified 36 pathological regions. The tumour-to-background ratio ranged from 1.44 to 2.17 (mean 1.63). Follow-up studies demonstrated a response to treatment, in that there was a reduction in, or complete disappearance of, localized tetrofosmin uptake in regions previously pathological, and a decrease in tumour-to-background ratios. Tetrofosmin appears suitable for the localization of lymphomatous lesions, especially supradiaphragmatic ones, and for the follow-up of therapeutic response.

Topics: Adult; Aged; Female; Follow-Up Studies; Hodgkin Disease; Humans; Male; Middle Aged; Neoplasm Staging; Organophosphorus Compounds; Organotechnetium Compounds; Reproducibility of Results; Time Factors; Tomography, Emission-Computed