technetium-tc-99m-sulfur-colloid and Thyroid-Neoplasms

This study was designed to review the diagnostic performance of sentinel node (SN) detection for assessment of the nodal status in thyroid carcinoma patients and to determine the technique (using blue dye or Technetium-99m colloid (99mTc) that demonstrated the highest success rate with regard to the detection rate and sensitivity.. A comprehensive computer literature search of studies published in English language through December 2007 and regarding SN procedures in patients with thyroid disorders was performed in MEDLINE. Pooled values regarding the SN detection rate and the pooled sensitivity values of the SN procedure were presented with a 95% confidence interval (CI) for the different SN detection techniques.. Ultimately, we identified 14 studies comprising a total of 457 patients. Of these, ten studies (n = 329 patients) used the blue dye technique with a pooled SN detection of 83% (95% CI, 79-87%). The remaining four studies (n = 128) used 99mTc-colloid with a pooled SN detection of 96% (95% CI, 91-99%; p < 0.05 vs. blue dye technique).. In patients with suspected thyroid carcinoma, SN biopsy demonstrated a higher SN detection rate when 99mTc was used (96%) instead of the blue dye technique (83%).

Topics: Chi-Square Distribution; Humans; Lymphatic Metastasis; Radionuclide Imaging; Radiopharmaceuticals; Rosaniline Dyes; Sensitivity and Specificity; Sentinel Lymph Node Biopsy; Technetium Tc 99m Sulfur Colloid; Thyroid Neoplasms

The detection of nonpalpable recurrent thyroid carcinoma has increased due to the use of imaging techniques in time. This report is to investigate whether preoperative injection of a radiotracer under ultrasound guidance is useful in nonpalpable recurrent thyroid carcinoma. The neck of two patients with recurrent thyroid carcinoma was scanned with the probe to localize the area of maximal radioactivity allowing appropriate location of the incision over the lesion. After the lymph nodes were removed, radioactivity was measured in the lesion bed to confirm the success of the dissection. In conclusion, the radio-guided nonpalpable lesion localization technique can be performed safely for the detection and excision of metastatic foci.

Topics: Biopsy, Fine-Needle; Humans; Iodine Radioisotopes; Lymph Node Excision; Lymphatic Metastasis; Male; Middle Aged; Radionuclide Imaging; Rhenium; Technetium Tc 99m Sulfur Colloid; Thyroid Neoplasms; Thyroidectomy; Ultrasonography

We examined the feasibility of sentinel lymph node biopsy for papillary thyroid cancer. In the dye injection method, 1% of isosulfan blue dye was injected around the tumor of 32 patients intra-operatively, and in the radioisotope (RI) colloid injection method, 99mTc-tin colloid was injected in 23 patients 1 day preoperatively. Lymph node mapping for detection of sentinel nodes was performed after thyroidectomy and central and modified lateral neck lymph node dissections. All dissected nodes were examined postoperatively by hematoxylineosin staining to determine whether or not metastasis was present. In the dye injection method, sentinel lymph nodes were identified in 30 (94%) of the 32 patients. Lymph node metastases were found in 14 patients, and some sentinel lymph nodes had papillary cancer metastasis in 13 patients. There was only 1 false-negative case. Sensitivity and accuracy of sentinel lymph node biopsy was 93% (13/14) and 97% (29/30). With the RI method, detection rate, sensitivity and accuracy of sentinel lymph node biopsy was 96% (22/23), 90% (9/10) and 95% (21/22), respectively. Our preliminary study indicated that sentinel lymph node biopsy was feasible in patients with thyroid cancer. It may be helpful in avoiding unnecessary lymph node dissection and improving quality of life in patients with thyroid cancer.

Topics: Carcinoma, Papillary; Humans; Lymph Node Excision; Lymph Nodes; Lymphatic Metastasis; Radiopharmaceuticals; Risk Assessment; Rosaniline Dyes; Sensitivity and Specificity; Sentinel Lymph Node Biopsy; Technetium Tc 99m Sulfur Colloid; Thyroid Neoplasms; Thyroidectomy; Treatment Outcome

A case of iodine-131 accumulation in the gall bladder following an ablative dose for thyroid carcinoma is presented.

Topics: Carcinoma, Papillary; Female; Gallbladder; Gallbladder Diseases; Humans; Iodine Radioisotopes; Middle Aged; Radionuclide Imaging; Technetium Tc 99m Sulfur Colloid; Thyroid Neoplasms; Thyroidectomy

Imaging with I-131 MIBG has proved useful for the detection of pheochromocytoma, neuroblastoma, and other neoplasms of neural crest origin. The authors present a case of a patient who was initially diagnosed as having follicular carcinoma of the thyroid in which I-131 MIBG played a key role in leading to the diagnosis of medullary carcinoma of the thyroid. Local and distant metastases were detected using I-131 MIBG imaging. Uptake of I-131 MIBG by medullary carcinoma of the thyroid has both diagnostic and therapeutic implications.

Topics: 3-Iodobenzylguanidine; Adenocarcinoma, Follicular; Antineoplastic Agents; Carcinoma, Medullary; Humans; Iodine Radioisotopes; Iodobenzenes; Liver Neoplasms; Male; Middle Aged; Radionuclide Imaging; Technetium Tc 99m Sulfur Colloid; Thyroid Neoplasms

Thirty-four patients with surgically documented medullary carcinoma of the thyroid (MCT) and elevated serum calcitonin levels had Tc-99m phosphate bone and/or Tc-99m sulfur colloid liver images for suspected metastases. Liver images demonstrated metastatic lesions in nine of 32 patients (28%). Bone images were positive for metastases in eight of 30 patients (27%). Four of these eight abnormal bone studies detected only skeletal lesions, two demonstrated only extraosseous metastases, and two showed both kinds. Of 18 patients with both radionuclide bone studies and skeletal radiographs, four demonstrated skeletal metastases, and lesions were recognized on both examinations. This study demonstrates that radionuclide bone and liver images frequently detect metastatic lesions in patients with MCT and elevated serum calcitonin levels, and that some nonskeletal metastases in patients with this tumor display an unusual affinity for bone-seeking radiotracers.

Topics: Adolescent; Adult; Aged; Bone Neoplasms; Carcinoma; Child; Female; Humans; Liver Neoplasms; Male; Middle Aged; Phosphates; Radiography; Radionuclide Imaging; Splenic Neoplasms; Technetium; Technetium Tc 99m Sulfur Colloid; Thyroid Neoplasms