technetium-tc-99m-sulfur-colloid and Sepsis

The effect of injection or chronic infusion of lipopolysaccharide (LPS) into unanaesthetized rats on the distribution of [99Tcm-]SC has been determined. At a dose of 2.5 mg/kg, LPS injection caused a marked alteration in the distribution of the radiolabelled material, with more uptake being achieved in the lung while less was taken up by the spleen. Kidney and liver uptake were also changed. Chronic infusion of LPS at a similar dose (3 mg/kg in 24 h) caused a marked increase in the uptake of the radioactive material by the lung only. These data are consistent with a working hypothesis that the alterations in RES phagocytic activity of the lung observed in rats subjected to burn trauma could be related in part to LPS, either coming as a bolus, or being continuously presented.

Topics: Animals; Burns; Female; Lipopolysaccharides; Lung; Mononuclear Phagocyte System; Phagocytosis; Rats; Sepsis; Technetium Tc 99m Sulfur Colloid

Topics: Adult; Aged; Drug Evaluation; Factor VIII; Fibrinogen; Fibronectins; Humans; Liver; Middle Aged; Peritonitis; Phagocytosis; Postoperative Period; Radionuclide Imaging; Sepsis; Technetium Tc 99m Sulfur Colloid

Since the scintillation camera enables us to include lower thorax in the views obtained during Tc-99m colloid imaging of the liver and spleen, intrathoracic pathology may be identified as relatively cold or hot areas in the thoracic cavity. Eighteen patients who underwent Tc-99m sulfur colloid imaging during a one-year period were found to have intrathoracic pathology demonstrated either as photopenic areas or as areas of increased radioactivity. These patients' clinical data and the results of other diagnostic modalities, including autopsy, were correlated with the Tc-99m images. The intrathoracic disease processes recognized were bacteremia, two cases; pleural effusion, two cases; lung pathology, one case; and cardiomegaly, 13 cases. With the Exception of two patients with bacteremia who had substantial radiocolloid sequestration by the lung, all the other patients had hepatic dysfunction. The presence of compromised hepatic function allows the visualization of intrathoracic abnormalities: photopenia suggesting pleural fluid collection or an enlarged cardiac silhouette (either photopenia or increased radioactivity occupying a large space in the anterior view to yield cardiothoracic ratio of greater than 50%). Therefore, Tc-99m sulfur during colloid liver-spleen imaging, patients with hepatic dysfunction may incidentally demonstrate intrathoracic pathology, especially cardiomegaly.

Topics: Aged; Cardiomegaly; Humans; Liver; Lung Diseases; Male; Middle Aged; Pleural Effusion; Radionuclide Imaging; Retrospective Studies; Sepsis; Spleen; Technetium Tc 99m Sulfur Colloid

Topics: Abscess; Aged; Diagnosis, Differential; Female; Gallium Radioisotopes; Humans; Pentetic Acid; Radionuclide Imaging; Retroperitoneal Space; Sepsis; Sulfur; Technetium; Technetium Tc 99m Pentetate; Technetium Tc 99m Sulfur Colloid

Topics: Adult; Humans; Liver; Liver Abscess; Male; Metronidazole; Peptococcus; Radionuclide Imaging; Sepsis; Sulfur; Technetium; Technetium Tc 99m Sulfur Colloid; Tooth Extraction