technetium-tc-99m-sulfur-colloid and Schistosomiasis-mansoni

Hepatic fibrosis in the pathogenesis of schistosomal glomerulopathy cannot be explained by any positive influence of hepatocellular injury. In order to examine the potential role of impairment of hepatic macrophage function, the t1/2 plasma clearance of 99mTc-sulphur colloid was studied in 30 patients with schistosomal glomerulopathy, ten normal volunteers, ten cases of uncomplicated intestinal schistosomiasis, ten non-schistosomal cirrhotic patients and ten non-schistosomal nephrotic patients. Liver and renal biopsies were obtained from appropriate groups and examined by light microscopy and glomerular immunofluorescence. There was a significant correlation between t1/2 of sulphur colloid clearance and proteinuria, mesangial hypercellularity, and predominance of IgA glomerular deposits. These data indicate that hepatic macrophage dysfunction is an important factor in the pathogenesis of schistosomal glomerulopathy, and that IgA plays a major role in advanced glomerular lesions. The degree of impairment of hepatic macrophage function may influence the pattern and severity of glomerular lesions depending upon the affection of IgA clearance mechanisms.

Topics: Adult; Female; Glomerulonephritis, Membranoproliferative; Humans; Liver Cirrhosis; Macrophages; Male; Middle Aged; Phagocytosis; Proteinuria; Schistosomiasis mansoni; Technetium Tc 99m Sulfur Colloid

Liver-spleen scintigrams were performed in 42 patients with chronic hepatosplenic schistosomiasis. The scan patterns found are described and classified in five stages of increasing hepatic involvement. The scintigraphic classification correlates well with clinical parameters of disease severity. With higher stages, the number of symptoms and the severity of complications increase. The liver-spleen scan provides a simple and accurate means to determine extent of hepatic involvement and probabilities of complications in this disease.

Topics: Chronic Disease; Humans; Liver; Liver Diseases, Parasitic; Prognosis; Radionuclide Imaging; Schistosomiasis mansoni; Spleen; Splenic Diseases; Technetium Tc 99m Sulfur Colloid