technetium-tc-99m-sulfur-colloid and Purpura--Thrombocytopenic

This paper presents a case of an 80-year-old man with idiopathic thrombocytopenic purpura after splenectomy performed many years ago, which normalized platelet count, presented with severe thrombocytopenia with no response to treatment. A SPECT/CT study was performed using 99mTc-labelled Sn-colloid. The histology confirmed the presence of splenic tissue in those foci. Spleen examination (SPECT/CT) using 99mTc-labelled Sn-colloid is able to detect splenic tissue and in our opinion is a simpler and less time-consuming procedure than using 99mTc DRBC.

Topics: Aged, 80 and over; Humans; Male; Multimodal Imaging; Positron-Emission Tomography; Postoperative Complications; Purpura, Thrombocytopenic; Radiopharmaceuticals; Spleen; Splenectomy; Technetium Tc 99m Sulfur Colloid; Tomography, X-Ray Computed

A 17 x 12 x 5-cm giant intrapelvic mass in a 14-year-old girl is reported. This mass developed 6 years after a splenectomy for splenic torsion. The heat-denatured 99mTc-labelled red cell scan and 99mTc-sulphur-colloid scan confirmed the specific red cell sequestration function and reticuloendothelial activity in the giant intrapelvic spleen. The size and development of the giant intrapelvic spleen are unusual. The usefulness of functional images to diagnosis the nature of the intrapelvic mass is well demonstrated.

Topics: Adolescent; Diagnosis, Differential; Erythrocytes; Female; Humans; Purpura, Thrombocytopenic; Radionuclide Imaging; Radiopharmaceuticals; Spleen; Splenectomy; Technetium; Technetium Tc 99m Sulfur Colloid; Tomography, X-Ray Computed

Ten children underwent splenic imaging with heat-denatured red blood cells labeled with technetium-99m (Tc-99m DRBC). The presenting problems included the heterotaxia syndrome, recurrent idiopathic thrombocytopenic purpura following splenectomy, mass in the left posterior hemithorax, and blunt abdominal trauma. In nine patients, the presence or absence of splenic tissue was established. A splenic hematoma was identified in the tenth patient. All patients were initially scanned with Tc-99m sulfur colloid (Tc-99m SC), and were selected for Tc-99m DRBC scintigraphy only after the results of the SC scans failed to establish the clinical problem beyond doubt. The availability of kits containing stannous ions, essential for efficient and stable labeling of red blood cells with Tc-99m and requiring only a small volume of blood, make splenic scintigraphy in children a relatively simple and definitive diagnostic procedure, when identification of splenic tissue is of clinical importance.

Topics: Abdominal Injuries; Adolescent; Child, Preschool; Erythrocytes; Female; Humans; Infant; Infant, Newborn; Isotope Labeling; Male; Purpura, Thrombocytopenic; Radionuclide Imaging; Reagent Kits, Diagnostic; Spleen; Sulfur; Syndrome; Technetium; Technetium Tc 99m Sulfur Colloid