technetium-tc-99m-sulfur-colloid and Leukemia--Lymphoid

In-111 WBC scintigraphy in a woman with relapsed acute lymphoid leukemia demonstrated normal uptake of white blood cells by the liver and spleen, but virtually absent bone marrow activity. Tc-99m SC imaging confirmed normal marrow function and distribution. A bone marrow biopsy revealed mildly hypocellular, regenerating marrow without leukemic infiltration. The effects of systemic cytotoxic chemotherapy on marrow reticuloendothelial function may have been responsible for this discordant uptake.

Topics: Bone Marrow; Female; Humans; Indium Radioisotopes; Leukemia, Lymphoid; Leukocytes; Middle Aged; Radionuclide Imaging; Technetium Tc 99m Sulfur Colloid

2 patients with premortem marrow necrosis in acute leukemia are discussed. A review of the course of each patient plus those in the literature suggests that premortem marrow necrosis may not be a poor prognostic sign in acute lymphoblastic leukemia but generally precedes a prolonged and fatal pancytopenia in acute myelogenous leukemia. The technetium-99m rhenium sulfur colloid marrow scan was found to be of value in assessing the extent and degree of necrosis of the marrow as well as in documenting and predicting marrow recovery following chemotherapy.

Topics: Aged; Biopsy, Needle; Bone Marrow; Bone Marrow Examination; Female; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Necrosis; Prognosis; Radionuclide Imaging; Rhenium; Sulfur; Technetium; Technetium Tc 99m Sulfur Colloid

Topics: Bronchial Neoplasms; Carcinoma, Small Cell; Cell Count; Cell Movement; Hot Temperature; Humans; Indium; Leukemia, Lymphoid; Liver; Lung; Lymphocytes; Radioisotopes; Spleen; Sulfur; Technetium; Technetium Tc 99m Sulfur Colloid

Topics: Adolescent; Adult; Aged; Bone Marrow; Drug Therapy, Combination; Female; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Middle Aged; Radionuclide Imaging; Scintillation Counting; Sulfur; Technetium; Technetium Tc 99m Sulfur Colloid

Topics: Abscess; Adult; Aeromonas; Antineoplastic Agents; Escherichia coli Infections; Female; Gallium Radioisotopes; Humans; Immunosuppression Therapy; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Splenic Diseases; Sulfur; Technetium; Technetium Tc 99m Sulfur Colloid; Ultrasonography