technetium-tc-99m-sulfur-colloid and Hodgkin-Disease

Topics: Amyloidosis; Colloids; Fatty Liver; Glycogen Storage Disease; Granuloma; Hepatitis, Viral, Human; Hodgkin Disease; Humans; Liver Cirrhosis; Liver Diseases; Liver Diseases, Alcoholic; Liver Neoplasms; Radionuclide Imaging; Sulfur; Technetium; Technetium Tc 99m Sulfur Colloid

Aim of the study was to observe the impact of bone marrow damage induced by local irradiation on leukopenia.. For the human study, five cancer patients received local radiation therapy. Bone marrow aspiration was conducted to measure nucleated cell count and 99mTc-Sc sulfur colloid ECT imaging was carried out to examine bone marrow function. For the animal study, fifty New Zealand white rabbits were divided into 3 groups: non-irradiated control group (N.=10), abdomen irradiation group (irradiation area did not cover bone marrow) (N.=20), chest irradiation group (irradiation area covered bone marrow) (N.=20). Nucleated cell counts were taken after confirming onset of leukopenia.. Bone marrow of five patients proliferated normally. ECT imaging showed no abnormality in the pattern of red bone marrow distribution. Hematopoietic function was mildly active.. Suppressed myeloproliferative function does not fully account for irradiation-induced leukopenia.

Topics: Animals; Bone Marrow; Bone Marrow Cells; Cell Proliferation; Esophageal Neoplasms; Female; Hodgkin Disease; Humans; Leukocytes; Leukopenia; Lung Neoplasms; Male; Nasopharyngeal Neoplasms; Rabbits; Radionuclide Imaging; Technetium Tc 99m Sulfur Colloid

Methods for determining spleen size in vivo have many clinical applications. Spleen size can be estimated accurately in vivo from measurements of length (L) and width (W) of the spleen silhouette as visualized by a scintillation camera after administration of technetium-99m (99mTc) sulfur colloid to the patient. Assuming mass and volume are proportional, spleen weight will depend on (L x W)3/2. Estimates of spleen size using these parameters obtained from scintigraphs were compared to actual determinations following splenectomy. Within the range of observations, the method had a standard deviation of 45 grams. It is safe, fast, and inexpensive.

Topics: Hodgkin Disease; Humans; Liver; Organ Size; Radionuclide Imaging; Radiopharmaceuticals; Regression Analysis; Retrospective Studies; Spleen; Splenectomy; Splenomegaly; Technetium Tc 99m Sulfur Colloid

A new technique of splenic localization, before initiating radiation therapy in patients with Hodgkin's disease, is described. We find this method of splenic localization economical and accurate.

Topics: Hodgkin Disease; Humans; Methods; Radionuclide Imaging; Spleen; Technetium Tc 99m Sulfur Colloid

Prognosis and proper treatment in Hodgkin's disease (HD) are strictly related to staging accuracy: liver and spleen involvement is of particular importance in this regard. We have evaluated, in 113 consecutive patients, the accuracy of clinical parameters to detect histologically documented HD involvement by comparing hepatosplenomegaly, liver function tests, liver and spleen scan, inspection of liver and spleen surface at laparoscopy with histologic findings. Our data suggest that of all the parameters studied, laparoscopy has the highest sensitivity and specificity values (about 100%). Laparoscopy may precede laparotomy as a staging procedure in HD and may give, in patients not submitted to laparotomy whatever the reasons, very reliable information.

Topics: Adolescent; Adult; Aged; Hodgkin Disease; Humans; Laparoscopy; Laparotomy; Liver Function Tests; Liver Neoplasms; Middle Aged; Neoplasm Staging; Prognosis; Splenic Neoplasms; Sulfur; Technetium; Technetium Tc 99m Sulfur Colloid

Two hundred six technetium-99m sulfur colloid bone marrow scans in 110 pediatrics patients were reviewed. The normal distribution of sulfur colloid in the lower extremities in various age groups was established. There was progressive loss of uptake with increasing age from less than two years to greater than ten years. Tumor replacement was seen as regions of decreased radioactivity, and the extent of the scan defect paralleled the response of the disease to therapy. Both chemotherapy and irradiation resulted in an extension of the Tc-99m SC to peripheral marrow sites. In irradiated areas, marrow scan defects were demonstrated and generally recovered normal activity by six months after the completion of therapy. Marrow scan abnormalities caused by tumor replacement were present in four patients despite normal bone scans and radiographs. Ultimate confirmation of tumor involvement was by needle aspiration or biopsy. Persistent marrow defects were seen in two patients with neuroblastoma who had remission of their disease: biopsy revealed myelofibrosis. Technetium-99m sulfur colloid bone marrow scanning is a sensitive monitor of altered marrow activity associated with pediatric hematologic or oncologic diseases.

Topics: Bone Marrow; Child; Child, Preschool; Hodgkin Disease; Humans; Lymphoma; Neoplasms; Neuroblastoma; Prospective Studies; Radionuclide Imaging; Reference Values; Sarcoma, Ewing; Sulfur; Technetium; Technetium Tc 99m Sulfur Colloid; Wilms Tumor

Topics: Fibrosarcoma; Gold Colloid, Radioactive; Hodgkin Disease; Humans; Lymph Nodes; Lymphatic Metastasis; Lymphedema; Lymphoma, Follicular; Radionuclide Imaging; Retroperitoneal Space; Sulfur; Technetium; Technetium Tc 99m Sulfur Colloid; Teratoma

Topics: Colloids; Drug Evaluation; Hodgkin Disease; Humans; Liver; Liver Neoplasms; Organotechnetium Compounds; Phytic Acid; Rhenium; Spleen; Splenic Neoplasms; Sulfur; Technetium; Technetium Compounds; Technetium Tc 99m Sulfur Colloid; Tomography, Emission-Computed

Topics: Adolescent; Child; Child, Preschool; Chylothorax; Hodgkin Disease; Humans; Lymph Node Excision; Lymphedema; Lymphoscintigraphy; Neuroblastoma; Pelvic Neoplasms; Postoperative Complications; Sulfur; Technetium; Technetium Tc 99m Sulfur Colloid

Three patients had chest radiographs suggesting pathology associated with the right hemidiaphragm. The patients' histories included trauma in one case, recently diagnosed leukemia in a second, and Hodgkin's disease in the third. In all three cases, the Tc-99m-sulfur colloid liver scan provided a noninvasive identification of the nature of the diaphragmatic densities seen on the chest radiographs, thus affecting patient management.

Topics: Adolescent; Diagnosis, Differential; Diaphragm; Female; Hodgkin Disease; Humans; Leukemia; Liver; Male; Middle Aged; Radiography; Radionuclide Imaging; Sulfur; Technetium; Technetium Tc 99m Sulfur Colloid; Wounds and Injuries

Thirty seven patients with lymphomatous disease were studied to detect abdominal lymph nodes involvement by means of lymph nodes scan with 99Tcm-sulfur-microcolloid, ultrasounds scans, lymphangiographies. Lymphangiography was considered as reference standard in patients which explorative laparotomy was not performed in. Isotopic method demonstrated high sensitivity, despite low specificity. Opposite results were obtained by ultrasounds. We concluded that isotopic abdominal lymph nodes scan is a clinically valuable test, if negative, while ultrasounds are, if positive. Both methods, specially if associated, proved quite useful in restaging after therapy, where important parameters are low risk and stress for the patients, easy execution, low costs.

Topics: Aged; Female; Hodgkin Disease; Humans; Lymph Nodes; Lymphoma; Middle Aged; Neoplasm Staging; Radionuclide Imaging; Sulfur; Technetium; Technetium Tc 99m Sulfur Colloid; Tomography; Ultrasonography