technetium-tc-99m-sulfur-colloid and Hemorrhage

Three cases of postpartum hepatic hemorrhage in the syndrome of hemolysis, elevated liver enzymes, and low platelet count (HELP) were diagnosed by Tc-99m sulfur colloid liver-spleen scanning. Two patients had follow-up scans. One showed rapid resolution of the hematoma on the repeat scan performed six days later, while the other showed delayed resolution on the repeat scan four weeks later. All patients received non-surgical supportive therapy with or without blood transfusion after delivery, and recovered well. Usefulness of radionuclide liver-spleen scanning in the diagnosis of peripartum hepatic hemorrhage and monitoring course of the disease is emphasized.

Topics: Adult; Female; Hemolysis; Hemorrhage; Humans; Liver; Liver Diseases; Pre-Eclampsia; Pregnancy; Puerperal Disorders; Radionuclide Imaging; Syndrome; Technetium Tc 99m Sulfur Colloid; Thrombocytopenia

The authors evaluated a method of detecting urinary tract bleeding using Tc-99m sulfur colloid in a canine model.

Topics: Animals; Dogs; Hemorrhage; Kidney Diseases; Radionuclide Imaging; Technetium Tc 99m Sulfur Colloid

Liver--spleen scintigraphy in patients who have incurred blunt abdominal trauma is accepted as a useful diagnostic tool. Abdominal and pelvic imaging to detect extrahepatic or extrasplenic sites of hemorrhage should be a routine part of liver--spleen imaging in the evaluation of blunt abdominal injury. A patient with mesenteric bleeding and a normal liver and spleen detected by liver--spleen scintigraphy is reported.

Topics: Abdomen; Abdominal Injuries; Aged; Hemorrhage; Humans; Liver; Male; Mesentery; Pelvis; Radionuclide Imaging; Spleen; Technetium Tc 99m Sulfur Colloid; Wounds, Nonpenetrating

After the intravenous administration of Tc-99m sulfur colloid, there was found homogeneous lung, renal, and splenic uptake with absence of uptake by the liver and bone marrow of a nine-day-old female infant. More than 20 other doses were dispensed from the same Tc-99m sulfur colloid preparation with the expected biodistribution. A necropsy done two days later showed diffuse hepatic hemorrhagic necrosis without evidence of intravascular fibrin deposition in the lungs or kidneys. The underlying cause of the infant's disease was a Coxsackie B2 viral infection, based upon positive postmortem viral cultures of kidney and liver tissues and characteristic histopathologic lesions of the central nervous system and viscera. The altered biodistribution presumably reflected marked impairment of Kupffer cell function and an apparent increase in pulmonary macrophages.

Topics: Coxsackievirus Infections; Enterovirus B, Human; Female; Hemorrhage; Hepatitis, Viral, Human; Humans; Infant, Newborn; Infant, Newborn, Diseases; Liver; Liver Diseases; Necrosis; Radionuclide Imaging; Sulfur; Technetium; Technetium Tc 99m Sulfur Colloid

A case is discussed of a man who presented with trauma to the chest and abdomen. A radiocolloid image showed uptake by the liver. However, the spleen was not identified. Areas of activity outside of the spleen were noted. The patient had splenic avulsion; extra sites of activity likely represented bleeding sites in the abdomen. Failure to identify the spleen on a radiocolloid image, after trauma, should be an alerting sign to possible splenic avulsion (especially when there are also ectopic sites of accumulation of the radiocolloid).

Topics: Hemorrhage; Humans; Male; Middle Aged; Radionuclide Imaging; Spleen; Splenic Diseases; Sulfur; Technetium; Technetium Tc 99m Sulfur Colloid

Topics: Abdomen; Aged; Colloids; Gastrointestinal Hemorrhage; Hemorrhage; Humans; Meckel Diverticulum; Radiography; Radionuclide Imaging; Rectal Diseases; Sigmoid Diseases; Sodium Pertechnetate Tc 99m; Sulfur; Technetium; Technetium Tc 99m Sulfur Colloid

Topics: Hemorrhage; Humans; Pulmonary Atelectasis; Radionuclide Imaging; Sulfur; Technetium; Technetium Tc 99m Sulfur Colloid

Topics: Adult; Female; Hemorrhage; Humans; Radionuclide Imaging; Spleen; Sulfur; Technetium; Technetium Tc 99m Sulfur Colloid; Wounds, Nonpenetrating

Tc99m-sulfur colloid scintigraphy has proven clinically useful in identifying gastrointestinal hemorrhages. The authors describe a patient with recurrent hemothorax under oral anticoagulation therapy in which Tc-99m-sulfur colloid imaging was used to determine the site of bleeding.

Topics: Adult; Anticoagulants; Heart Valve Prosthesis; Hemorrhage; Hemothorax; Humans; Male; Radionuclide Imaging; Recurrence; Sulfur; Technetium; Technetium Tc 99m Sulfur Colloid

Topics: Adult; Erythrocytes; Female; Hemorrhage; Humans; Lung; Lung Diseases; Radionuclide Imaging; Sulfur; Technetium; Technetium Tc 99m Sulfur Colloid

Pulmonary hemorrhage, whether in the form of hemoptysis or bleeding into the pleural space, may be a life threatening problem. While fiberoptic bronchoscopy and selective bronchial and intercostal angiography are the major diagnostic modalities, these techniques are not without risks. Two patients are described-one with massive hemoptysis from a bronchogenic carcinoma; another with pleural bleeding from a torn intercostal artery-in whom Tc-99m-sulfur colloid scintigraphy accurately located the source of hemorrhage. We conclude that Tc-99m-sulfur colloid scintigraphy may be a helpful noninvasive method to increase the sensitivity and specificity of fiberoptic bronchoscopy and bronchial angiography in patients with massive pulmonary bleeding.

Topics: Adult; Angiography; Bronchoscopy; Carcinoma, Bronchogenic; Diagnosis, Differential; Fiber Optic Technology; Hemoptysis; Hemorrhage; Humans; Lung Diseases; Lung Neoplasms; Male; Middle Aged; Pleura; Radionuclide Imaging; Sulfur; Technetium; Technetium Tc 99m Sulfur Colloid

Topics: Aged; Hemorrhage; Humans; Ileal Diseases; Male; Radionuclide Imaging; Sulfur; Technetium; Technetium Tc 99m Sulfur Colloid