technetium-tc-99m-sulfur-colloid and Esophagitis

Topics: Chronic Disease; Esophagitis; Esophagus; Female; Gastroesophageal Reflux; Humans; Middle Aged; Radionuclide Imaging; Radiopharmaceuticals; Stomach; Technetium Tc 99m Sulfur Colloid

We studied intraesophageal pressure changes in patients with symptoms of gastroesophageal reflux and an abnormal 24-hr pH monitoring record (N = 52). Our method was simultaneous esophageal manometry and pH monitoring. We observed a three-component esophageal manometric sequence (EMS). When this sequence recurred over and over, we termed this phenomenon "cycling." We found cycling in 35% of the patients (18/52). Those with cycling had lower basal LES pressures, more acid exposure, and an increased incidence of endoscopic esophagitis. That cycling resulted from repeated reflux events and their esophageal clearance was documented by scintigraphy during simultaneous manometry and pH monitoring (N = 7 patients). Cycling was found on the routine esophageal manometry record of 25% of symptomatic patients (N = 112) with an abnormal 24-hr pH score. In conclusion, cycling represents an esophageal manometric phenomenon due to repetitive reflux events. Its recognition during esophageal manometry may denote a severe reflux diathesis.

Topics: Adult; Eating; Esophagitis; Esophagoscopy; Esophagus; Female; Gastric Acidity Determination; Gastroesophageal Reflux; Humans; Male; Manometry; Middle Aged; Monitoring, Physiologic; Periodicity; Posture; Radionuclide Imaging; Recurrence; Retrospective Studies; Technetium Tc 99m Sulfur Colloid

The 'single swallow' technique for the isotopic investigation of oesophageal function has been widely accepted. In our experience the results obtained when several consecutive 'single swallow' tests are performed show considerable variation. Although one or two swallows may be enough to diagnose abnormality, the exclusion of a motility disorder requires more, preferably six consecutive swallows.

Topics: Adult; Deglutition; Esophagitis; Esophagus; Humans; Male; Organometallic Compounds; Pentetic Acid; Peristalsis; Radionuclide Imaging; Technetium Tc 99m Pentetate; Technetium Tc 99m Sulfur Colloid

Esophageal transit of a small volume of watery liquid has been observed scintigraphically in 200 studies performed on patients aged between 6 days and 16 years. Qualitative information concerning esophageal morphology and function in the various phases of deglutition, and scintigraphic features of achalasia, stenosis, and other pathologies are described. Measured esophageal transit time and its normal variation, its relevance to the diagnosis of esophagitis, and the monitoring of treatment are discussed. This technique observing distinct deglutitions has proven a useful diagnostic tool. Its advantages and limitations are discussed in comparison with other methods.

Topics: Adolescent; Child; Child, Preschool; Esophagitis; Esophagus; Female; Gastroesophageal Reflux; Humans; Infant; Infant, Newborn; Male; Radionuclide Imaging; Sulfur; Technetium; Technetium Tc 99m Sulfur Colloid