technetium-tc-99m-sulfur-colloid and Connective-Tissue-Diseases

Topics: Connective Tissue Diseases; Defecography; Deglutition Disorders; Digestive System; Esophageal Motility Disorders; Esophagus; Food; Gastric Emptying; Gastroesophageal Reflux; Gastrointestinal Motility; Humans; Isotope Labeling; Muscular Diseases; Peristalsis; Radioactive Tracers; Radionuclide Imaging; Reference Values; Technetium Tc 99m Sulfur Colloid

A better understanding of scintigraphic findings may lead to a wider acceptance of esophageal transit studies. The purpose of this study, therefore, was to correlate standard manometric parameters with the quantitative and qualitative characteristics of liquid and semi-solid bolus transport. Twenty-nine patients were simultaneously investigated with esophageal scintigraphy and manometry. Single-swallow and sum-image data of six consecutive swallows were analyzed. No significant relationship between transit time and the velocity of the peristaltic wave could be identified, which suggests that factors other than peristaltic velocity (e.g., pharyngeal pump) essentially modulate esophageal transit. There was also no linear correlation between esophageal emptying and peristaltic amplitudes. Emptying was normal in patients with amplitudes greater than 30 mmHg and reduced in those with amplitudes less than 30 mmHg. This suggests that a threshold pressure greater than 30 mmHg is necessary to propel a test bolus adequately. Patterns in condensed images have been shown to specifically reflect the events in corresponding manometric recordings. Normal and different pathologic types of peristalsis presented analogous findings in both modalities. Thus, an analysis of the relationship between bolus transport and contraction parameters in simultaneous studies increases understanding of quantitative and qualitative scintigraphic results.

Topics: Adult; Aged; Connective Tissue Diseases; Deglutition; Deglutition Disorders; Diabetes Mellitus, Type 1; Esophagus; Female; Gastroesophageal Reflux; Germany; Humans; Male; Manometry; Middle Aged; Prospective Studies; Radionuclide Imaging; Technetium Tc 99m Sulfur Colloid

A simultaneous dual isotope technique incorporating computer subtraction for the diagnosis of bone, joint, or soft-tissue infection using [67Ga]citrate and [99mTc]MDP or sulfur colloid is described. Comparison of this technique with visual congruence or noncongruence of the two radionuclide images in 41 patients shows that the two techniques have identical sensitivity (93%) and specificity (92%) but the computer technique gave additional information in 17% of all cases (44% of abnormals) concerning the anatomic location of the infective focus which aided in the subsequent surgical management of the patient.

Topics: Adolescent; Adult; Aged; Bone Diseases; Child; Child, Preschool; Computers; Connective Tissue Diseases; Diphosphonates; Female; Gallium Radioisotopes; Humans; Infections; Male; Middle Aged; Radionuclide Imaging; Subtraction Technique; Technetium; Technetium Tc 99m Medronate; Technetium Tc 99m Sulfur Colloid