technetium-tc-99m-sulfur-colloid and Cerebral-Hemorrhage

technetium-tc-99m-sulfur-colloid has been researched along with Cerebral-Hemorrhage* in 2 studies

Other Studies

2 other study(ies) available for technetium-tc-99m-sulfur-colloid and Cerebral-Hemorrhage

ArticleYear
Optimized thrombolysis of cerebral clots with tissue-type plasminogen activator in a rabbit model of embolic stroke.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 264, Issue:1

    The dose-dependent effects of tissue-type plasminogen activator (t-PA) on the kinetics of cerebral clot lysis in a rabbit model of middle cerebral artery embolic stroke were investigated. The clots were formed in vitro and tagged with 99Tc for gamma-scintigraphic imaging. After embolization, groups of animals were treated with t-PA. Dose-response curves for the t-PA were generated, and in addition, long and short dosing schedules were assessed. The optimal doses for frequency and rate of cerebral clot lysis in this model are approximately 6.3 mg/kg given over 2 hr or 3.3 mg/kg given over 30 min. These dosing regimens for t-PA were accompanied by approximately 50% consumption of plasma plasminogen, fibrinogen and alpha 2-antiplasmin. Doses of t-PA on either side of this optimum caused attenuation in both the frequency and rate of cerebral clot lysis. Treatment with t-PA under either dosing regimen did not augment the frequency of hemorrhagic transformation, but the size of the resultant hemorrhage in those animals where intracranial bleeding occurred was reduced by 3.3 mg/kg t-PA given over 30 min.

    Topics: Animals; Cerebral Arteries; Cerebral Hemorrhage; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Intracranial Embolism and Thrombosis; Male; Rabbits; Technetium Tc 99m Sulfur Colloid; Thrombolytic Therapy; Tissue Plasminogen Activator

1993
Detection of intracranial bleeding by 99mTc sulfur colloid scintigraphy.
    AJR. American journal of roentgenology, 1985, Volume: 144, Issue:1

    Topics: Cerebral Hemorrhage; Child, Preschool; Female; Humans; Radionuclide Imaging; Technetium Tc 99m Sulfur Colloid

1985