technetium-tc-99m-sulfur-colloid and Abnormalities--Multiple

Topics: Abnormalities, Multiple; Female; Humans; Infant, Newborn; Intellectual Disability; Lymphedema; Lymphoscintigraphy; Male; Obstetric Labor, Premature; Pregnancy; Preoperative Care; Radiopharmaceuticals; Syndrome; Technetium Tc 99m Sulfur Colloid

For the evaluation of a variety of hepatosplenic disorders, SPECT complements planar 99mTc-sulfur colloid liver/spleen imaging. By isolating small, ectopic or poorly functioning spleen(s) from overlying or adjacent liver, SPECT imaging should facilitate identification of splenic tissue in infants with suspected heterotaxy syndrome.. During a 10-yr period, 10 planar-only and 9 planar-plus-SPECT liver/spleen scans were obtained from 15 infants, 13 of whom were less than 1 mo of age at first examination. Four of the planar-only group had follow-up planar-plus-SPECT imaging. Scintigraphic diagnosis regarding presence of splenic tissue was correlated with clinical diagnosis.. Thirteen infants had splenic tissue; two were asplenic. Planar-only imaging provided correct diagnoses in six [four with, two without spleen(s)] but was negative or equivocal in four infants. Planar-plus-SPECT imaging was positive in all in whom it was performed; moreover, in 4/13 infants (31%), splenic tissue was documented only by SPECT imaging.. Particularly when planar views are inconclusive, SPECT imaging is invaluable for identification and localization of functioning splenic tissue in infants with suspected heterotaxy syndrome.

Topics: Abnormalities, Multiple; Female; Heart Defects, Congenital; Humans; Infant; Infant, Newborn; Liver; Male; Retrospective Studies; Sensitivity and Specificity; Situs Inversus; Spleen; Syndrome; Technetium Tc 99m Sulfur Colloid; Tomography, Emission-Computed, Single-Photon

Over 10 years, 8 infants required surgery for central diaphragmatic herniation. Contrast peritoneography and technetium-99m-sulfur colloid radionuclide scanning were the most definitive diagnostic aids. Associated anomalies included variations of the pentalogy of Cantrell. A midline gastroduodenal loop was found in two infants. Six infants are alive and well 6 months to 3 years postoperatively. An abdominal approach is preferred if there is an intestinal hernia, associated gastrointestinal anomalies, or if a bilateral defect is present.

Topics: Abnormalities, Multiple; Female; Follow-Up Studies; Hernia, Diaphragmatic; Hernias, Diaphragmatic, Congenital; Humans; Infant, Newborn; Liver; Male; Radiography; Radionuclide Imaging; Stomach; Sulfur; Technetium; Technetium Tc 99m Sulfur Colloid

Microgastria is a rare congenital anomaly usually associated with asplenia. In this 2 1/2-year-old presenting with left hydrocele and inguinal hernia multiple accessory spleens were found in the inguinal-scrotal region compatible with splenic-gonadal fusion. 99mTc-sulfur colloid scanning is helpful in microgastria searching for the presence of splenic tissue and in splenic-gonadal fusion for the location of accessory heterotopic spleens.

Topics: Abnormalities, Multiple; Adult; Child, Preschool; Female; Gonadal Dysgenesis; Humans; Male; Radionuclide Imaging; Spleen; Stomach; Sulfur; Technetium; Technetium Tc 99m Sulfur Colloid; Testis

Splenic-gonadal fusion is an unusual congenital anomaly resulting from the fusion of the splenic and gonadal anlagen at approximately the sixth week of gestation. A 14-mo-old male presenting with signs and symptoms of testicular torsion underwent scrotal exploration, and ectopic splenic tissue was found adjacent to the left testis. The operative diagnosis of splenic-gonadal fusion prompted abdominal scanning with 99mTc-sulfur colloid. The radionuclide image demonstrated an unusual pattern of activity that was consistent with surgical description of the intraabdominal appearance of this disorder. It is suggested that 99mTc-sulfur colloid scanning may prove to be a useful adjunct in the evaluation of patients with this anomaly.

Topics: Abnormalities, Multiple; Colloids; Humans; Infant; Male; Radionuclide Imaging; Spleen; Sulfur; Technetium; Technetium Tc 99m Sulfur Colloid; Testis