technetium-tc-99m-pyrophosphate and Retroperitoneal-Neoplasms

Osteoscintigraphy and dynamic scintigraphy of the kidneys with 99mTc-pyrophosphate were used for investigation of 24 pediatric patients with tumorous involvement of the retroperitoneal space. Bone metastases were detected by osteoscintigraphy in 8 patients, pathological changes of the kidneys and urinary tract in 9 patients. Dynamic investigation of the kidneys with 99mTc-pyrophosphate performed in the first 20 min. after the drug injection showed disorders of renal evacuatory function of a varied degree of expression in all 24 patients. Dynamic investigation of the kidneys with 99mTc-pyrophosphate was not accompanied by an increase in radiation exposures therefore it was recommended at the first stage of radionuclide investigation of children with tumorous involvement of the retroperitoneal space followed by osteoscintigraphy.

Topics: Adult; Bone Neoplasms; Child; Child, Preschool; Diphosphates; Hodgkin Disease; Humans; Infant; Kidney Neoplasms; Neuroblastoma; Radioisotope Renography; Retroperitoneal Neoplasms; Technetium; Technetium Tc 99m Pyrophosphate; Wilms Tumor

In static scintigraphy with 99m Tc-pertechnetate of primary lesions of the retroperitoneal space in children 4 types of scintigraphic pictures were singled out for differential diagnosis of Wilms' tumors, avascular benign lesions of the retroperitoneal space and neurogenic retroperitoneal tumors. The sensitivity of diagnosis of Wilms' tumor was 92.6%, specificity 90.9%. The most objective and complete information on the kidney involvement in tumor process could be obtained in static scintigraphy with 99m Tc-pertechnetate combined with scintigraphy with 99m Tc-gluconate or 99m Tc-pyrophosphate. The sensitivity of diagnosis of secondary lesions of the lymph nodes of the retroperitoneal space was 76.8%.

Topics: Adolescent; Child; Child, Preschool; Diphosphates; Gluconates; Humans; Infant; Kidney Neoplasms; Organotechnetium Compounds; Radionuclide Imaging; Retroperitoneal Neoplasms; Sodium Pertechnetate Tc 99m; Technetium; Technetium Tc 99m Pyrophosphate; Wilms Tumor

Topics: Adolescent; Bone Neoplasms; Child; Child, Preschool; Female; Humans; Infant; Mediastinal Neoplasms; Neuroblastoma; Radiography; Radionuclide Imaging; Retroperitoneal Neoplasms; Technetium; Technetium Tc 99m Pyrophosphate; Tin Polyphosphates