technetium-tc-99m-pyrophosphate and Psoriasis

The authors presented the results of clinical, x-ray and osteoscintigraphic investigations of 133 psoriatic arthritis patients and 72 patients with common psoriasis. Osteoscintigraphy was performed using a routine method with 99mTc-pyrophos (USSR) and 99mTc-phosphone (Hungary) on gamma-camera LFOV (Nuclear-Chicago, USA). X-ray signs of the involvement of the osteoarticular system were noted in 69 (51%) patients with psoriatic arthritis and in 16 (22%) patients with common psoriasis. The method permitted the detection of the foci of RP hyperfixation in 129 (97%) patients with psoriatic arthritis and in 51 (70.8%) patients with common psoriasis. They were observed mostly in large and small limb joints, less frequently--in the vertebral column, cranial bones, thorax, and ribs. Thus, osteoscintigraphy is a highly sensitive method for the detection of active inflammatory foci of the osteoarticular system in psoriasis at all stages of arthritis development. It makes it possible to detect the spreading of arthritis and its preclinical forms.

Topics: Arthritis; Bone and Bones; Chronic Disease; Diphosphates; Evaluation Studies as Topic; Humans; Psoriasis; Radiography; Radionuclide Imaging; Technetium; Technetium Tc 99m Pyrophosphate

Topics: Arthritis; Diphosphates; Humans; Joints; Psoriasis; Radionuclide Imaging; Sodium Pertechnetate Tc 99m; Technetium; Technetium Tc 99m Pyrophosphate

Topics: Arthritis; Diphosphates; Humans; Joints; Psoriasis; Radionuclide Imaging; Sodium Pertechnetate Tc 99m; Technetium; Technetium Tc 99m Pyrophosphate

A juxtaposition between the clinical-laboratory, immunologic and radionucleotide articular parameters was performed in 50 patients with psoriatic arthropathy, distributed according to the incidence of X-ray manifestations. The late and moderate changes in ESK, leukocytes, fibrinogen, DPA and phosphatasemia do not characterize the severity of the disease. A tendency to hyperuricemia and hypercalcemia is established in the period of arthralgia before the X-ray image for bone-tissue damage. The genetic HLA-B27 predetermination plays a certain role for the more frequent involvement of the spine and sacroiliac joints in the pathological process. The disturbances in the immune system are manifested with increased number of early T-lymphocytes, FcG-receptor lymphocytes, complement (C3b)--receptor lymphocytes and spontaneously blast-transformed cells. The increasing IgG content correlates with the accumulation of macromorphological X-ray images and with the index of mineral metabolism from the articular study with 99MTc-pyrophosphate. The changes in the pertechnetium index for articular vascularization are quantitatively insignificant and do not allow the joining of the psoriatic arthropathy to the group of primary synoviarthritis. The accumulation of technetium pyrophosphate in the articular structures is asymmetric, focal and precedes the changes in the X-ray image.

Topics: Adult; Alkaline Phosphatase; Arthritis; Blood Proteins; Blood Sedimentation; Calcium; Diphosphates; Female; Fibrinogen; Humans; Leukocyte Count; Male; Middle Aged; Psoriasis; Sodium Pertechnetate Tc 99m; T-Lymphocytes; Technetium; Technetium Tc 99m Pyrophosphate; Uric Acid

Topics: Adult; Aged; Arthritis; Diphosphates; Female; Humans; Male; Middle Aged; Psoriasis; Radionuclide Imaging; Technetium; Technetium Tc 99m Pyrophosphate