technetium-tc-99m-pyrophosphate and Liver-Neoplasms

Topics: Aged; Diagnosis, Differential; Erythrocytes; Gastrointestinal Hemorrhage; Humans; Ileal Neoplasms; Ileum; Liver Neoplasms; Male; Neuroendocrine Tumors; Radionuclide Imaging; Technetium Tc 99m Pyrophosphate

Cavernous hemangioma is the most common benign tumor of the liver, the organ in which these lesions are most often present. We report on 28 patients who underwent 99mTc-labeled red cell scintigraphy after ultrasound or computerized tomography images suggesting the existence of one or more hepatic angiomas. In 16 patients (57.1%), an accumulation of red blood cells was considered to indicate the existence of hemangiomas. On the basis of subsequent clinical follow-up, ultrasound studies, and in one case laparotomy, all were eventually confirmed to be hemangiomas. The specificity as 100%. In the remaining 12 patients (42.9%), red cell uptake was not observed and the findings were considered negative; in this group, there were 10 true negatives and 2 false negatives in which scintigraphy failed to detect the existing angiomas due to their small size and deep location. The sensitivity was 88.8%. On the basis of the results, it is concluded that labeled red cell scintigraphy is a highly sensitive and specific method for the diagnosis of cavernous hemangioma of the liver. It should be considered the method of choice when this lesion is suspected, thus avoiding the use of more invasive diagnostic procedures such as laparoscopy which, in our study proved to be unnecessary.

Topics: Adult; Aged; Erythrocytes; Female; Gamma Cameras; Hemangioma, Cavernous; Humans; Liver Neoplasms; Male; Middle Aged; Radionuclide Imaging; Radiopharmaceuticals; Sensitivity and Specificity; Technetium Tc 99m Pyrophosphate; Technetium Tc 99m Sulfur Colloid; Time Factors

By means of ultrasonography it is possible to detect hepatic lesions of few millimeters, however, it doesn't give a precise diagnosis. The role of planar scintigraphy in the diagnosis of hepatic hemangioma has already been established, although it has limitations which are partially solved by means of SPECT. 46 patients with different pathologies and 9 healthy volunteers have been studied. In the 19 confirmed hemangiomas, planar scintigraphy showed a sensitivity of 73.6% versus 84.2% for SPECT, mostly due to lesions less than 2.5 cm. Besides that, SPECT allowed a correct visualization of abdominal and intrahepatic major vessels, although lesions less than 1.5 cm are difficult to evaluate.

Topics: Adult; Aged; Erythrocytes; Female; Hemangioma; Humans; Liver; Liver Neoplasms; Male; Middle Aged; Scintillation Counting; Technetium Tc 99m Pyrophosphate; Tomography, Emission-Computed, Single-Photon

The objective of this study is to correlate the presence of bone and liver metastases in patients with breast cancer with respect to the results of bone and liver scans, axillary nodal status, and serum alkaline phosphatase levels. One hundred ninety-seven patients with breast cancer treated by modified radical mastectomy between the years 1978 and 1981 were studied. Fifty-nine (30%) of the total group had distant metastases during the course of observation of 60 to 96 months; of 35 patients in whom bone metastases developed, 30 had normal preoperative bone scan results. Of 21 patients who had liver metastases, 19 had normal preoperative liver scans. Nineteen (70%) of the 27 patients with abnormal bone scans had normal alkaline phosphatase levels. Seven (63%) of the 11 patients who had abnormal liver scans had a normal alkaline phosphatase. The study supports the concept that preoperative bone and liver scans are ineffective indicators of metastatic involvement. Selection of patients for screening by bone and liver scans according to alkaline phosphatase determinations was not supported by this study. The appropriate use of bone scans for screening in patients with breast carcinoma is suggested as a follow-up device in patients with positive lymph nodes.

Topics: Alkaline Phosphatase; Bone Neoplasms; Breast Neoplasms; Diphosphates; Female; Humans; Liver Neoplasms; Mastectomy; Radionuclide Imaging; Technetium; Technetium Tc 99m Pyrophosphate; Technetium Tc 99m Sulfur Colloid

Sequential liver scintiphotography with Tc-99m pyrophosphate (PYP) was used to prospectively evaluate its uptake patterns in hepatoma. The scintiphotos and time-activity curves of 40 cases were analyzed. Two distinct patterns of tumor activity were noted: gradual but complete extraction and trapping of Tc-99m PYP in hepatoma in 38% of the patients (group 1), and absence of subsequent Tc-99m PYP uptake in hepatoma after initial blood pool activity in 62% of the patients (group 2). Since extraction and trapping of Tc-99m PYP occur approximately in two fifths of the patients with hepatoma, we conclude that Tc-99m PYP liver scintigraphy is not worthwhile supplementing the conventional radionuclide studies for diagnosing hepatoma, even in the selected patients in the countries where the prevalence of hepatoma is high.

Topics: Carcinoma, Hepatocellular; Diphosphates; Humans; Liver; Liver Neoplasms; Prospective Studies; Radionuclide Imaging; Technetium; Technetium Tc 99m Pyrophosphate; Technetium Tc 99m Sulfur Colloid; Time Factors

Topics: Carcinoma; Diphosphates; Female; Humans; Liver Neoplasms; Radionuclide Imaging; Technetium; Technetium Tc 99m Pyrophosphate; Thyroid Neoplasms

A case of small cell anaplastic carcinoma of the lung with hepatic secondaries has been found to accumulate Tc-99m-pyrophosphate in both lung primary and hepatic metastases and to our knowledge is the first such case reported in the literature. There was no radiographic evidence of calcification in the tumor or hepatic metastases.

Topics: Aged; Bone and Bones; Diphosphates; Humans; Liver Neoplasms; Lung Neoplasms; Male; Radionuclide Imaging; Technetium; Technetium Tc 99m Pyrophosphate