technetium-tc-99m-pyrophosphate and Hypertrophy--Left-Ventricular

Amyloid deposition was frequently observed in the removed tenosynovium of elderly men with CTS. Cardiac screening may be useful for early diagnosis of CA in patients undergoing CTR with amyloid deposition.

Topics: Aged; Amyloidosis; Carpal Tunnel Syndrome; Female; Humans; Hypertrophy, Left Ventricular; Male; Prevalence; Technetium Tc 99m Pyrophosphate

The diagnosis of wild-type transthyretin cardiac amyloidosis (ATTRwt) is frequently missed or delayed because of the limited specificity of manifestations. We investigated the utility of combined assessment of high-sensitivity cardiac troponin T (hs-cTnT) measurement and. We divided 39 consecutive ATTRwt patients into two groups depending on whether serum hs-cTnT measurement and. Diagnostic yield was higher in group B than in group A (1.2 vs. 5.4 ATTRwt patients per 1000 hospitalized patients, p<0.01). Group B patients presented broad clinical features that were different from group A patients with classical characteristics. Atrial fibrillation was more frequent (12.5% vs. 58.1%, p=0.044) and inter-ventricular septum (IVS) thickness and relative wall thickness (RWT) were smaller in group B patients than in group A patients (IVS thickness: 16.1±2.4mm vs. 13.6±2.8mm, p=0.023; RWT: 0.71±0.11mm vs. 0.58±0.13mm, p=0.014). Furthermore, left ventricular hypertrophy (LVH) (IVS thickness ≥15mm) was more frequent in patients in group A than in patients in group B (87.5% vs. 33.3%, p=0.013). No significant difference was observed in the mean value of left ventricular ejection fraction (LVEF), whereas the dispersion of LVEF was high in group B (interquartile range: 47-58% vs. 39-57%).. An integrated approach consisting of hs-cTnT measurement and

Topics: Aged; Aged, 80 and over; Amyloid Neuropathies, Familial; Female; Heart Ventricles; Humans; Hypertrophy, Left Ventricular; Male; Radionuclide Imaging; Technetium Tc 99m Pyrophosphate; Troponin T; Ventricular Function, Left