technetium-tc-99m-pyrophosphate and Hodgkin-Disease

Osteoscintigraphy and dynamic scintigraphy of the kidneys with 99mTc-pyrophosphate were used for investigation of 24 pediatric patients with tumorous involvement of the retroperitoneal space. Bone metastases were detected by osteoscintigraphy in 8 patients, pathological changes of the kidneys and urinary tract in 9 patients. Dynamic investigation of the kidneys with 99mTc-pyrophosphate performed in the first 20 min. after the drug injection showed disorders of renal evacuatory function of a varied degree of expression in all 24 patients. Dynamic investigation of the kidneys with 99mTc-pyrophosphate was not accompanied by an increase in radiation exposures therefore it was recommended at the first stage of radionuclide investigation of children with tumorous involvement of the retroperitoneal space followed by osteoscintigraphy.

Topics: Adult; Bone Neoplasms; Child; Child, Preschool; Diphosphates; Hodgkin Disease; Humans; Infant; Kidney Neoplasms; Neuroblastoma; Radioisotope Renography; Retroperitoneal Neoplasms; Technetium; Technetium Tc 99m Pyrophosphate; Wilms Tumor

A total of 401 patients: 148 men, 134 women and 119 children with Hodgkin's disease were examined to determine the diagnostic value of the radioisotope and x-ray methods in the early detection of metastatic involvement of the skeletal bones. Specific skeletal bone lesions were revealed in 72 patients. Metastatic lesions of the skeletal bones develop more frequently in adults than in children. No significant differences in the site of metastases were noted. Radioisotope examination is an earlier diagnostic method in the early detection of metastatic involvement of the skeletal bones in Hodgkin's disease and more informative in the diagnosis of costal and cranial bone lesions.

Topics: Adolescent; Adult; Aged; Bone Neoplasms; Child; Child, Preschool; Diphosphates; Female; Hodgkin Disease; Humans; Male; Middle Aged; Radiography; Radionuclide Imaging; Technetium; Technetium Tc 99m Pyrophosphate