technetium-tc-99m-pyrophosphate and Cardiovascular-Diseases

The authors examined 98 patients with different cardiovascular diseases and 20 practically healthy subjects and established that complex use of pirphotech with 99mTc-pertechnetate gives an objective information on circulatory disorders in the myocardium. Radionuclide ventriculography in the static variant should be carried out early for obtaining adequate information on the state of cardiodynamics.

Topics: Adult; Cardiovascular Diseases; Gamma Cameras; Gated Blood-Pool Imaging; Heart; Humans; Indicators and Reagents; Middle Aged; Organic Chemicals; Radionuclide Generators; Sodium Pertechnetate Tc 99m

"Persistently abnormal" technetium-99m stannous pyrophosphate myocardial scintigrams (PPi+) appear to be associated with a relatively poor prognosis after acute myocardial infarction (AMI). To assess the incidence and implications of PPi+, we performed a retrospective analysis in 29 patients with and 25 patients without diabetes mellitus who had abnormal myocardial scintigrams within 4 days of AMI and who had follow-up scintigrams at least 3 months after hospital discharge. There were no significant differences between patients with and without diabetes as regards age, incidence of transmural or nontransmural AMI, or degree of left ventricular dysfunction after AMI. Persistently abnormal PPi+ occurred more commonly in patients with diabetes than in nondiabetic patients (18 of 29, 62%, compared to 3 of 25, 12%; p less than 0.001). Patients with chronic PPi+ had more frequent cardiac complications following hospital discharge (p less than 0.005) including death, recurrent AMI, unstable angina, and intractable congestive heart failure. Postmortem analysis in two patients with diabetes and chronic PPi+ revealed marked myocytolysis. Thus, patients with diabetes mellitus have an increased incidence of post-AMI "persistently abnormal" technetium (PPi+) scintigrams and relatively poor prognosis following myocardial infarction.

Topics: Aged; Cardiovascular Diseases; Creatine Kinase; Diabetes Complications; Diabetes Mellitus; Diphosphates; Female; Follow-Up Studies; Heart; Humans; Insulin; Male; Middle Aged; Myocardial Infarction; Myocardium; Prognosis; Radionuclide Imaging; Retrospective Studies; Technetium; Technetium Tc 99m Pyrophosphate

Topics: Adult; Brain Diseases; Burns, Electric; Cardiovascular Diseases; Digestive System Diseases; Diphosphates; Diphosphonates; Female; Humans; Leukemia, Erythroblastic, Acute; Lung Diseases; Male; Middle Aged; Polyphosphates; Radionuclide Imaging; Splenic Diseases; Technetium; Technetium Compounds; Technetium Tc 99m Pyrophosphate; Urologic Diseases