technetium-tc-99m-pyrophosphate and Cardiotoxicity

Topics: Antirheumatic Agents; Cardiomyopathies; Cardiotoxicity; Female; Humans; Hydroxychloroquine; Lupus Erythematosus, Systemic; Middle Aged; Radiopharmaceuticals; Technetium Tc 99m Pyrophosphate; Tomography, Emission-Computed, Single-Photon

Taking an overdose of AMT, a commonly prescribed tricyclic antidepressant drug, has an increased risk of sudden cardiac death. The cardiotoxicity of amitriptyline (AMT) is a commonly observed toxicity with high morbidity and mortality rates in emergency departments (ED). Nevertheless, there are still no effective treatment options for AMT-induced cardiotoxicity. The aim of the present study was to evaluate the effects of paricalcitol (PRC), a Vitamin D receptor agonist, using electrocardiographic (ECG), biochemical, and scintigraphic methods. Twenty-eight male Wistar rats were randomly divided into four groups: untreated control (CON), amitriptyline-induced cardiotoxicity (AMT), paricalcitol (PRC), and amitriptyline + paricalcitol (AMT + PRC). Cardiotoxicity was induced by intraperitoneal (i.p) injection of a single-dose AMT (100 mg/kg). PRC was administered as 10 μg/kg (i.p.) after the injection of AMT. We examined ECG, biochemical, and scintigraphic results of PRC administration on AMT-induced changes. Cardiotoxicity of AMT was characterized by conduction abnormalities (increased QRS complex, T wave, and QT interval duration and elevation of ST segment amplitude), elevated

Topics: Action Potentials; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Biomarkers; Cardiotoxicity; Disease Models, Animal; Electrocardiography; Ergocalciferols; Heart; Heart Diseases; Heart Rate; Male; Positron Emission Tomography Computed Tomography; Predictive Value of Tests; Radiopharmaceuticals; Rats, Wistar; Technetium Tc 99m Pyrophosphate; Troponin T

Topics: Aged; Amyloidosis; Antirheumatic Agents; Cardiotoxicity; Echocardiography; Female; Humans; Hydroxychloroquine; Positron Emission Tomography Computed Tomography; Sjogren's Syndrome; Technetium Tc 99m Pyrophosphate