technetium-tc-99m-pyrophosphate and Atrial-Fibrillation

Topics: Atrial Fibrillation; Bone and Bones; Diphosphates; Humans; Technetium; Technetium Tc 99m Pyrophosphate

Transthyretin cardiac amyloidosis (ATTR-CA) is an increasingly recognized disease, in which atrial fibrillation (AF) has been shown to be prevalent. Cardiac scintigraphy with technetium-99m-pyrophosphate (99mTc-PyP) labeled bone-seeking tracers is used to noninvasively make the diagnosis of ATTR-CA, based on ventricular myocardial uptake. Assessment of atrial wall uptake (AU) on 99mTc-PyP is currently not used in the clinical setting Methods: We analyzed a cohort of patients referred for 99mTc-PyP scan at a tertiary center to explore AU and associations between any and incident AF, ATTR-CA, and all-cause mortality.. Among 580 patients included, 296 patients (51%) had a diagnosis of AF; 164 patients (28%) had scans consistent with ATTR-CA while 117 patients (20%) had AU. Of 117 patients with AU, 107 (91%) had any AF. In contrast, of 463 patients without AU 191(41%) had any AF. Of those with AU, 59/117(50%) patients had a 99mTc-PyP diagnosis of ATTR-CA while 58/117(50%) patients did not have such a diagnosis (. In a consecutive cohort of patients undergoing 99mTc-PyP scans, 20% had AU, which was statistically associated with any AF, independently of ATTR-CA diagnosis and sex. AU was associated with significantly lower freedom from incident AF at 1-year. Overlooking AU on 99mTc-PyP scans could potentially miss an earlier disease manifestation, or an additional risk factor for any/incident AF.

Topics: Atrial Fibrillation; Cardiomyopathies; Diphosphates; Heart Atria; Humans; Prealbumin; Radionuclide Imaging; Stroke Volume; Technetium; Technetium Tc 99m Pyrophosphate; Ventricular Function, Left

Topics: Atrial Fibrillation; Diphosphates; Humans; Radionuclide Imaging; Technetium; Technetium Tc 99m Pyrophosphate

Topics: Atrial Fibrillation; Diphosphates; Humans; Radionuclide Imaging; Technetium; Technetium Tc 99m Pyrophosphate

Topics: Amyloidosis; Atrial Fibrillation; Cardiomyopathies; Diphosphates; Heart; Humans; Technetium Tc 99m Pyrophosphate

Aim was to study the performance of single-photon emission computed tomography (SPECT) with. The research included 70 patients (the average age of 49.3 ± 10.2 years) with persistent form of idiopathic AF. All patients underwent myocardium SPECT with. Sensitivity of SPECT with. The study showed the possibility of successful application of radionuclide methods for diagnoses of chronic latent myocarditis at AF. Taking into account high informative values the results of scintigraphy can be also considered as a promising additional criteria for selecting patients with AF of unexplained etiology for non-invasive endomyocardial biopsy procedure.

Topics: Atrial Fibrillation; Feasibility Studies; Female; Heart; Humans; Inflammation; Magnetic Resonance Imaging; Male; Middle Aged; Myocarditis; Sensitivity and Specificity; Technetium Tc 99m Pyrophosphate; Technetium Tc 99m Sestamibi; Tomography, Emission-Computed, Single-Photon

Topics: Acute Disease; Aged; Asthma; Atrial Fibrillation; Biopsy; Electrocardiography; Heart Septum; Humans; Hypereosinophilic Syndrome; Male; Myocarditis; Myocardium; Technetium Tc 99m Pyrophosphate; Tomography, Emission-Computed, Single-Photon; Ultrasonography

Cycle length windowing is gaining increasing acceptance in gated blood pool imaging of patients with atrial fibrillation (AF). The goals of this study were: to assess differences of ejection fraction (EF) in AF with and without windowing and to determine how EF varied with cycle length in patients with AF. Twenty patients with AF were prospectively studied by gated blood pool imaging, with simultaneous collection in each patient of 5-7 studies with cycle length windows spanning the cycle length histogram. Each window accepted beats of only a narrow range of cycle lengths. EF was determined for each of the narrow cycle length windows as well as for the entire gated blood pool study without cycle length windowing. For every patient an average of the windowed EFs was compared with the non-windowed EF. EF values were similar (mean windowed: 46.6; non-windowed: 45.5; P = 0.16), and there was a good correlation between the two techniques (r = 0.97). The data were then examined for a relationship of EF with cycle length. The difference from average windowed EF (delta EF) was calculated for each window and plotted vs. the cycle length of the center of each window. No predictable linear or nonlinear relationship of delta EF with window position was observed. Lack of predictable variation of EF with cycle length is likely due to lack of a predictable amount of ventricular filling for a given cycle length, as the amount of diastolic filling in AF depends on the random cycle length of the preceding beat.(ABSTRACT TRUNCATED AT 250 WORDS)

Topics: Atrial Fibrillation; Electrocardiography; Gated Blood-Pool Imaging; Humans; Stroke Volume; Technetium; Technetium Tc 99m Pyrophosphate; Tin Polyphosphates

Topics: Adult; Aged; Atrial Fibrillation; Electric Countershock; Heart; Humans; Middle Aged; Myocardium; Radionuclide Imaging; Technetium; Technetium Tc 99m Pyrophosphate; Tin Polyphosphates