technetium-tc-99m-medronate and Wilms-Tumor

Bone metastases are extremely rare in patients with classical Wilms' tumor (WT). We describe the clinical and radiologic features, treatment and outcome of three patients with WT (one with favorable histology and two with anaplasia) in whom bone metastases were detected at diagnosis or relapse. Bone metastases were documented by skeletal radiographs, computed tomography and/or bone scintigraphy. The patient with favorable histology WT had no evidence of pulmonary metastases and is now free of disease following aggressive chemotherapy and radiotherapy.

Topics: Biopsy, Needle; Bone Neoplasms; Child; Child, Preschool; Humans; Infant; Kidney Neoplasms; Lung Neoplasms; Male; Radionuclide Imaging; Technetium Tc 99m Medronate; Tomography, X-Ray Computed; Wilms Tumor

Topics: Child; Diagnosis, Differential; Diphosphonates; Humans; Kidney Neoplasms; Male; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate; Wilms Tumor

Technetium-99m methylene diphosphonate (99mTc MDP) imaging was performed in 29 consecutive children with abdominal masses. Dynamic images of the inferior vena cava were obtained by injecting the radiotracer in the feet. Serial renal images were obtained for the next 30 min. Routine bone imaging was performed at about 3 hr. The radionuclide studies of the inferior vena cava accurately diagnosed total obstruction and displacement to the left but not partial obstruction and displacement to the right. The abnormalities on early renal imaging included displacement (14), distortion (seven), obstruction (eight), and nonvisualization (one). All patients with Wilms tumor (eight) had either nonvisualized or distorted renal parenchyma. Patients with neuroblastoma (17) and other tumors (four) had displacement and obstruction. Soft-tissue accumulation of 99mTc MDP was noted in two Wilms tumors and 12 neuroblastomas.

Topics: Abdominal Neoplasms; Child; Diphosphonates; Humans; Kidney Neoplasms; Neuroblastoma; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate; Vena Cava, Inferior; Wilms Tumor

Topics: Bone and Bones; Child, Preschool; Diphosphonates; Humans; Male; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate; Thoracic Neoplasms; Wilms Tumor