technetium-tc-99m-medronate and Vitamin-D-Deficiency

Topics: Alkaline Phosphatase; Humans; Hypercalcemia; Hyperparathyroidism, Primary; Male; Middle Aged; Osteitis Deformans; Pelvic Bones; Radiography; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate; Vitamin D Deficiency

Topics: Adult; Calcium Citrate; Cholecalciferol; Emigration and Immigration; Female; Germany; Humans; Osteomalacia; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate; Vitamin D; Vitamin D Deficiency

Topics: Adult; Bone Density; Calcitriol; Fatty Acids; Female; Humans; Malabsorption Syndromes; Muscle Weakness; Technetium Tc 99m Medronate; Vitamin D Deficiency; Wheelchairs

A patient with osteomalacia secondary to vitamin D deficiency after gastrectomy for gastric cancer is presented. Initial bone scintigrams showed both asymmetric and symmetric focal areas of intense uptake due to pseudofractures reminiscent of bone metastases. Radiographs only confirmed the presence of pseudofractures at some, but not all, of the abnormal sites demonstrated by bone scintigraphy. At first, metastatic bone disease was suspected. However, the appearance of repeated bone scintigram was normalized after treatment with vitamin D. A diagnosis of osteomalacia was established. The present case serves to illustrate that symmetric focal lesions are important features of pseudofractures secondary to osteomalacia, and comparison with radiographs and repeated bone scintigraphy are necessary in distinguishing between bone metastases and pseudofractures.

Topics: Bone and Bones; Bone Neoplasms; Diagnosis, Differential; Fractures, Bone; Gastrectomy; Humans; Male; Middle Aged; Osteomalacia; Postoperative Complications; Radionuclide Imaging; Stomach Neoplasms; Technetium Tc 99m Medronate; Vitamin D Deficiency

The effects of vitamin D-free diet with low Ca content on 24 hours' 99mTc-methylendiphosphonate retention (in the whole body and tibia), long-term the whole body 85Sr retention and 2 hours' 85Sr catchment in epiphysis, metaphysis and diaphysis of femur and tibia in rats (at the same time in certain experiments femur density and weight after incineration were established) were followed. The whole body 99mTc-MDP retention increases significantly as early as the third day of the diet administration, retention in tibia and the whole body is in further 2 experiments increased after 1, 2 and 4 weeks of the diet (density decreases from the first or the second week). The whole body 85Sr retention is significantly increased as early as after 2 days of the diet, the great difference against controls only slowly decreases after discontinuation of low-Ca diet. Further experiment followed 2 hours' 85Sr catchment in femur and tibia samples after 2, 5, 10 and 20 days of diet--catchment increase is significant after 20 days (bone density and ash weight is significantly decreased after 10 and 20 days of diet). Thus retention of both osteotrophic substances in bone is as a result of low Ca diet increased. This reaction is in case with 85Sr expected, in that of 99mTc-MDP it suggests a possible relation of the catchment and mineral component of osseous tissue. Increased retention of both the substances obviously fails to be related to local blood circulation which was in this situation in our previous experiments decreased.(ABSTRACT TRUNCATED AT 250 WORDS)

Topics: Animals; Bone and Bones; Calcium; Female; Male; Radionuclide Imaging; Rats; Strontium Radioisotopes; Technetium Tc 99m Medronate; Vitamin D Deficiency

Topics: Adult; Aged; Aged, 80 and over; Bone and Bones; Bone Diseases, Metabolic; Cholecalciferol; Female; Humans; Liver Cirrhosis; Male; Middle Aged; Radionuclide Imaging; Technetium Tc 99m Medronate; Vitamin D Deficiency