technetium-tc-99m-medronate and Vascular-Diseases

Topics: Adult; Female; Humans; Lupus Erythematosus, Systemic; Radionuclide Imaging; Radiopharmaceuticals; Ribs; Technetium Tc 99m Medronate; Vascular Diseases

Calciphylaxis is a highly morbid syndrome of vascular calcification and skin necrosis, the pathophysiology of which remains largely elusive. We report a patient with end-stage renal disease and multiple painful skin lesions who underwent a bone scan for extremity pain. Increased tracer accumulation was seen in the subcutaneous tissues of the trunk and lower extremities. In this case, the bone scan aided in the diagnosis and treatment of calciphylaxis for a patient who experienced a relatively short hospital stay.

Topics: Aged; Bone and Bones; Calcinosis; Calciphylaxis; Female; Humans; Kidney Failure, Chronic; Necrosis; Radionuclide Imaging; Radiopharmaceuticals; Skin Ulcer; Syndrome; Technetium Tc 99m Medronate; Vascular Diseases

The authors describe a complex regional pain syndrome (CRPS) and discuss its type according to the presence or absence of nerve injury. A patient underwent thromboendarterectomy of the right popliteal artery. Subsequently, right lower limb reflex sympathetic dystrophy developed, which was confirmed by scintigraphy and responded well to calcitonin treatment. Typing according to the new classification of CRPS type I or II with possible nerve injury is discussed, and a short review of the literature is included.

Topics: Aged; Causalgia; Complex Regional Pain Syndromes; Diagnosis, Differential; Endarterectomy; Foot; Humans; Male; Popliteal Artery; Radionuclide Imaging; Radiopharmaceuticals; Reflex Sympathetic Dystrophy; Technetium Tc 99m Medronate; Vascular Diseases; Whole-Body Counting

To describe the radionuclide three-phase whole-body bone imaging (TPWBBI) technique and discuss the usefulness of its application.. TPWBBI was performed after a single intravenous injection of 555 to 925 MBq (15 to 25 mCi) Tc-99m MDP. Whole-body arterial flow (phase one) followed by blood-pool and tissue perfusion (phase two) images were obtained with the moving detector head speed set at 150 cm/minute and 40 cm/minute, respectively. Conventional whole-body static bone images (phase three) were obtained 3 hours later.. When 542 consecutive TPWBBI results were reviewed, 394 (166 extraskeletal and 228 skeletal) abnormalities were detected during phases one and two. The 166 extraosseous lesions included vascular diseases: abdominal aortic aneurysms and peripheral vascular diseases and renal abnormalities, liver abnormalities, ascites, and pleural effusions. Many of these were incidentally detected clinically significant findings and would not have been identified on conventional static bone images. It helps to differentiate among acute and chronic fractures, active and inactive inflammatory diseases such as arthritis or osteomyelitis, and Paget's disease.. With a single injection of Tc-99m MDP, whole-body images obtained in the arterial phase, the blood-pool and tissue perfusion phase, and the static bone phase can identify many clinically significant skeletal and soft tissue abnormalities. TPWBBI can differentiate between active and inactive phases of different disease processes and thereby provide a diagnosis that is more specific than a conventional single-phase bone scan. It may be applicable as a tool for nuclear physical examination.

Topics: Adult; Aged; Aged, 80 and over; Bone Diseases; Diagnosis, Differential; Digestive System Diseases; Feasibility Studies; Female; Female Urogenital Diseases; Humans; Male; Male Urogenital Diseases; Middle Aged; Predictive Value of Tests; Radionuclide Imaging; Radiopharmaceuticals; Sensitivity and Specificity; Soft Tissue Neoplasms; Technetium Tc 99m Medronate; Vascular Diseases; Whole-Body Counting