technetium-tc-99m-medronate and Uterine-Cervical-Neoplasms

Insufficiency fractures (IFs) are a type of stress fracture caused by the effects of normal or physiological stresses on abnormally weakened bone. Frequently, these fractures are occult, and a portion of these fractures is misdiagnosed as bone metastases on a whole-body bone scan (WBS). The aim of this study was to evaluate a potential benefit of single-photon emission computed tomography/computed tomography (SPECT/CT) with metabolic and morphological imaging to diagnose IF in patients with cervical cancer after radiotherapy.. This article presents a retrospective review of 35 patients with cervical cancer after radiotherapy in patients (females; mean age, 55.94 ± 8.75 years; range, 36-73 years) who were referred to have WBS to determine whether there was any bone metastasis. The criterion standard was based on radiological investigations, clinical information, and follow-up at a minimum of 12 months.. Insufficiency fractures were most frequently observed in the sacrum, accounting for 52.5% (21/40) of lesions. Fracture lines or sclerotic lines were noted in the IF lesion in 19 of 40 lesions on CT, and osteosclerosis was seen in 31 of 40 lesions. On WBS analysis, the sensitivity for detected lesions was 87.5% (42/48) for WBS. Nineteen lesions were interpreted as benign, 6 lesions were malignant, and 21 (43.8%) lesions were equivocal. Based on the criterion standard, WBS had an accuracy of only 47.9% (23/48). On SPECT/CT analysis, all of the lesions were observed on SPECT/CT; only 3 (6.25%) of 48 lesions were equivocal, and the accuracy was 89.6% (43/48).. Single-photon emission computed tomography/computed tomography should be included in the differential diagnoses when lesions show elevated technetium Tc 99m-labeled methylene diphosphonate uptake on WBS. Compared with a WBS alone, a more accurate diagnosis of IF can be obtained using SPECT/CT, which resulted not only in fewer equivocal lesions but also in a higher diagnostic accuracy.

Topics: Adult; Aged; Bone Neoplasms; Female; Fractures, Stress; Humans; Middle Aged; Radiation Injuries; Radiopharmaceuticals; Retrospective Studies; Sacrum; Single Photon Emission Computed Tomography Computed Tomography; Technetium Tc 99m Medronate; Uterine Cervical Neoplasms; Whole Body Imaging

Topics: Bone and Bones; Female; Humans; Iatrogenic Disease; Middle Aged; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate; Ureter; Urologic Diseases; Uterine Cervical Neoplasms

Topics: Aged; Bone and Bones; Bone Neoplasms; Calcinosis; Chronic Disease; Female; Humans; Pancreatitis; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate; Tomography, X-Ray Computed; Uterine Cervical Neoplasms

Topics: Adenocarcinoma; Aged; Citrates; Female; Gallium; Gallium Radioisotopes; Humans; Peritoneal Neoplasms; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate; Uterine Cervical Neoplasms

Examination for liver and bone metastases was performed in 30 women suffering from carcinoma of the uterus and in 27 with cervical and 37 with ovarian carcinoma. Scintigraphy was the examination method of choice in bone metastases and computed tomography in liver metastases. Bone metastases were not seen in any patient in the stages I to IV with carcinoma of the cervix and ovarian carcinoma. Bone metastases were found in one patient in stage III and in one in stage IV with carcinoma of the uterus. Liver metastases were found in four patients in stages III and IV with carcinoma of the uterus and in five patients with ovarian carcinoma.

Topics: Bone Neoplasms; Female; Humans; Liver Neoplasms; Middle Aged; Neoplasm Staging; Ovarian Neoplasms; Technetium Tc 99m Medronate; Tomography, X-Ray Computed; Uterine Cervical Neoplasms; Uterine Neoplasms

Topics: Diphosphonates; Ethanolamines; Female; Hexoprenaline; Humans; Midodrine; Phenethylamines; Postoperative Complications; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate; Ureter; Urination Disorders; Uterine Cervical Neoplasms