technetium-tc-99m-medronate and Uremia

Topics: Bone and Bones; Calcinosis; Female; Heart; Humans; Kidney Failure, Chronic; Lung; Male; Middle Aged; Radionuclide Imaging; Renal Dialysis; Technetium Tc 99m Medronate; Uremia

Topics: Adult; Carcinoma; Enteral Nutrition; Heart; Humans; Lung; Male; Nasopharyngeal Neoplasms; Nutrition Disorders; Radionuclide Imaging; Radiopharmaceuticals; Stomach; Technetium Tc 99m Medronate; Thyroid Gland; Tissue Distribution; Uremia

To investigate the incidence rate, pathologic changes, mechanisms and diagnostic methods in renal bone disease.. The blood levels of carboxyterminal parpthyriod hormone (C-PTH), 1,25(OH)2D3, calcium and phosphate, aluminum in serum and bone tissue were measured. The bone biopsy and bone scan with 99m technetium methylene diphosphonate (99mTC-MDP) were performed in 51 uremic patients.. One hundred per cent of the patients had varying degree of pathologic changes in bone, in which 50.9% of the patients presented high-turnover bone disease, 7.8% of the patients presented low-turnover bone disease and 41.8% of the patients had mixed-type bone disease. The levels of serum C-PTH were predominently high in high-turnover bone disease while the levels of serum 1,25(OH)2D3 were significantly decreased in low-turnover bone disease. There was a high positive rate for the diagnosis of renal bone disease by bone scan with 99mTC-MDP.. The examination of bone pathology is the most valuable method for the diagnosis of renal bone disease. Bone scan with 99mTC-MDP has reference value when clinical conditions do not allow to make bone biopsy.

Topics: Adult; Aged; Biopsy; Bone Diseases, Metabolic; Female; Glomerulonephritis; Humans; Ilium; Male; Middle Aged; Radionuclide Imaging; Technetium Tc 99m Medronate; Uremia

Topics: Adult; Bone and Bones; Calcinosis; Humans; Male; Muscular Diseases; Radionuclide Imaging; Technetium Tc 99m Medronate; Uremia

The value of radionuclide bone scanning in the diagnosis of renal osteodystrophy is still debated. In order to re-examine this issue, 25 uremic patients treated by intermittent hemodialysis underwent 99m-Technetium Methylene Diphosphonate (99mTc-MDP) bone scan. They were subdivided into three groups according to quantitative bone histology. Group 1 (N = 8) had pure dialysis osteomalacia, group 2 (N = 7) mixed lesions, and group 3 (N = 10) pure osteitis fibrosa. The scintigraphic studies were interpreted by means of a five point semi-quantitative scale. Using this quantification, all but one group 1 patients had decreased bone tracer uptake, and all patients of group 3 had an increased uptake (chi square test of Yates, P less than 0.001). Among patients of group 2, bone uptake was decreased in the three patients with clearly reduced mineralization front and moderate osteitis fibrosa, but it was increased in all patients with severe osteitis fibrosa and subnormal mineralization front. A quantitative analysis of regional tracer uptake into bone was performed in two patients: one of group 2 and one of group 3. The results obtained clearly corroborated the semi-quantitative findings. Thus, in hemodialysis patients with symptomatic bone disease, the 99mTc-MDP bone scan provides useful information for the differential diagnosis between dialysis-related osteomalacia and secondary hyperparathyroidism. In patients with mixed lesions, the importance of bone tracer uptake appears to depend on the extent of the mineralization front and on the intensity of osteitis fibrosa.

Topics: Adult; Aged; Biopsy; Bone and Bones; Chronic Kidney Disease-Mineral and Bone Disorder; Female; Humans; Male; Middle Aged; Osteitis Fibrosa Cystica; Osteomalacia; Radionuclide Imaging; Renal Dialysis; Technetium Tc 99m Medronate; Uremia

Topics: Adult; Bone and Bones; Calcinosis; Calcium; Diphosphonates; Humans; Male; Middle Aged; Phosphorus; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate; Uremia

Topics: Adult; Aged; Biopsy; Bone and Bones; Chronic Kidney Disease-Mineral and Bone Disorder; Diphosphonates; Female; Humans; Male; Middle Aged; Technetium; Technetium Tc 99m Medronate; Tomography, Emission-Computed; Uremia

Topics: Adolescent; Adult; Bone and Bones; Chronic Disease; Chronic Kidney Disease-Mineral and Bone Disorder; Diphosphonates; Female; Humans; Male; Middle Aged; Polyphosphates; Radionuclide Imaging; Technetium; Technetium Compounds; Technetium Tc 99m Medronate; Uremia