technetium-tc-99m-medronate and Thrombosis

Many reasons could lead to abnormal increased extraosseous tracer uptake on Tc-MDP bone scintigraphy. A 75-year-old man was referred a bone scintigraphy to evaluate his chest pain. The images revealed rib fractures. In addition, increased MDP activity in the muscle of the lower extremities was noted. The abnormal increased uptake in the muscles was likely related to the arterial thromboses revealed by vascular ultrasonography. The patient received interventional embolectomy.

Topics: Aged; Arteries; Biological Transport; Humans; Lower Extremity; Male; Muscles; Radionuclide Imaging; Technetium Tc 99m Medronate; Thrombosis

The association between cancer and venous thrombosis is well established. However, that between malignancy and arterial thrombosis is less well described. We herein report a 48-year-old male patient diagnosed with base of tongue carcinoma, referred for Tc-methylene diphosphonate (MDP) bone scan study to evaluate recently developed pain and numbness in his right leg while undergoing chemoradiation. Tc-MDP bone scan study revealed complete absence of radiotracer distribution in the right lower limb below the knee region. This finding was inferred to be due to avascularity in this region secondary to thrombo-embolism that was substantiated by color Doppler sonography.

Topics: Arteries; Humans; Incidental Findings; Leg Bones; Male; Middle Aged; Radionuclide Imaging; Technetium Tc 99m Medronate; Thrombosis

Topics: Aged; Bacteremia; Catheterization, Central Venous; Humans; Indium Radioisotopes; Male; Radionuclide Imaging; Radiopharmaceuticals; Renal Dialysis; Subclavian Vein; Technetium Tc 99m Medronate; Thrombosis

Topics: Aged; Aged, 80 and over; Bone and Bones; Child; Female; Femoral Artery; Humans; Leg; Male; Radionuclide Imaging; Technetium Tc 99m Medronate; Thrombosis

Focal Tc-99m MDP uptake on bone scanning in regions of deep venous thrombosis (DVT) is reported in two patients with documented DVT. It is speculated that this uptake may be related to localized calcification or ossification, which is occasionally observed on radiographs of patients with chronic DVT.

Topics: Aged; Bone and Bones; Female; Femoral Vein; Humans; Iliac Vein; Leg; Middle Aged; Radionuclide Imaging; Technetium Tc 99m Medronate; Thrombosis

A new observation is reported wherein 99m Tc-MDP is incorporated into recanalizing thrombophlebitis. In one patient with subacute disease, inflammatory vascularity is appreciated during the first one to two minutes after injection. Both patients showed evidence of late phosphate uptake in their greater saphenous veins two hours later. Intravenous isotope injections may be given in an arm vein: foot injections are not required.

Topics: Adult; Bone and Bones; Diphosphonates; Female; Femoral Vein; Humans; Male; Radionuclide Imaging; Saphenous Vein; Staphylococcal Infections; Substance-Related Disorders; Technetium; Technetium Tc 99m Medronate; Thrombosis

A quadriplegic patient with a swollen leg was suspected of having deep-venous thrombosis, and was studied with radionuclide venography (RNV) and contrast venography. Focal narrowing of the femoral vein, seen on RNV, was due to extrinsic compression. Although soft-tissue radiographs were normal, Tc-99m diphosphonate imaging established the diagnosis of early heterotopic bone formation (myositis ossificans), which was responsible for the venous compression. Clinically this inflammatory process can mimic deep-venous thrombosis, and should be considered in evaluating patients at risk for both heterotopic bone formation and deep-venous thrombosis.

Topics: Adult; Diagnosis, Differential; Diphosphonates; Edema; Femoral Vein; Humans; Male; Myositis Ossificans; Quadriplegia; Radiography; Radionuclide Imaging; Technetium; Technetium Tc 99m Aggregated Albumin; Technetium Tc 99m Medronate; Thrombosis

Three-phase radionuclide scintigraphy of the hand was performed on 116 patients. Normal and abnormal patterns for radionuclide angiography, immediate post-injection blood-pool images, and delayed scans (3-4 hr.) were established. Of 80 patients with normal circulation, 61 (76%) had equal radial and ulnar artery flow bilaterally, while in 19 (24%) either the radial or ulnar artery was dominant. Abnormal studies were grouped into three categories: suspected vascular lesions (Group I), pain of uncertain etiology (Group II), and patients evaluated before and after reconstructive surgery (Group III). The diagnosis was correct in 89% of the patients in Group I (34/38), 89% of those in Group II (57/64), and all of those in Group III (14/14). Three-phase scintigraphy of the hand yields significant information about perfusion and bone metabolism.

Topics: Adolescent; Adult; Aged; Arteriovenous Malformations; Arthritis; Bone Neoplasms; Child; Child, Preschool; Diphosphonates; Female; Hand; Hand Injuries; Hemangioma; Humans; Male; Middle Aged; Radionuclide Imaging; Raynaud Disease; Reference Values; Regional Blood Flow; Technetium; Technetium Tc 99m Medronate; Thrombosis

Topics: Bone and Bones; Diphosphonates; Humans; Kidney; Male; Middle Aged; Pentetic Acid; Radionuclide Imaging; Renal Veins; Technetium; Technetium Tc 99m Medronate; Technetium Tc 99m Pentetate; Thrombosis