technetium-tc-99m-medronate and Stomach-Neoplasms

Unexpected extraosseous uptake is common on Tc-methylene diphosphonate bone scintigraphy, but accumulation by primary upper gastrointestinal tract malignant melanoma is rarely reported. The present case is a 58-year-old woman with a 10-day history of diffuse bone pain and weakness. Her bone scintigraphy showed unexpected diffuse gastric tracer uptake. Subsequent gastroscopy revealed a number of hyperpigmented lesions in the stomach and duodenal bulb. Malignant melanoma was confirmed by histopathology and immunohistochemistry. Because extensive physical examination failed to identify any other site of ocular and cutaneous melanoma, a diagnosis of primary upper gastrointestinal tract malignant melanoma was established.

Topics: Female; Humans; Melanoma; Middle Aged; Positron Emission Tomography Computed Tomography; Radiopharmaceuticals; Stomach Neoplasms; Technetium Tc 99m Medronate

A 47-year-old woman with a history of subtotal gastrectomy due to gastric cancer underwent bone scintigraphy to evaluate possible recurrent disease. The whole-body images revealed a single focus of elevated 99mTc-MDP activity in the right pubic region, which was located in the intrapelvic soft tissue on subsequent SPECT/CT images. Pathological examination after needle biopsy demonstrated that the soft tissue was an implantation metastasis from gastric cancer.

Topics: Female; Humans; Middle Aged; Pelvic Neoplasms; Stomach Neoplasms; Technetium Tc 99m Medronate; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; Whole Body Imaging

Topics: Adenocarcinoma; Bone Marrow Neoplasms; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Radionuclide Imaging; Radiopharmaceuticals; Stomach Neoplasms; Technetium Tc 99m Medronate; Tomography, X-Ray Computed

Diffuse metastatic visceral calcification is rare in breast cancer. We report on a 57-year-old woman with breast cancer and hypercalcemia who had diffuse metastatic visceral calcifications on lungs, myocardium, stomach, and thyroid on a (99m)Tc-methylene diphosphonate bone scan. Visceral calcifications were completely resolved 6 months after successful anticancer and zoledronic acid treatments. Bone scanning offers a useful diagnostic tool for both identifying visceral calcification and assessing the response to therapy in chemosensitive malignities with hypercalcemia such as breast cancer.

Topics: Antineoplastic Agents; Bone and Bones; Breast Neoplasms; Calcification, Physiologic; Calcium; Diphosphonates; Female; Heart Neoplasms; Humans; Imidazoles; Lung Neoplasms; Middle Aged; Neoplasm Metastasis; Stomach Neoplasms; Technetium Tc 99m Medronate; Thyroid Neoplasms; Time Factors; Zoledronic Acid

A 54 year old man presenting a so-called super bone scan is reported. The patient had a past history of subtotal gastrectomy due to early gastric cancer 19 years previously. Laboratory data indicated microcytic anemia and high serum alkaline phosphatase. Both the serum calcium and phosphate levels were within normal ranges. In spite of extensive examination for a primary malignant lesion in the organs including the remaining stomach, no solid tumors were identified. Pathological examinations revealed that the tumor cells in the biopsy specimen from the lumbar spine were almost identical to those in the gastric cancer excised 19 years previously. We considered that micrometastases in the bone marrow existed at the time of the initial surgery for gastric cancer and reappeared 19 years later showing super bone scan.

Topics: Adenocarcinoma; Bone Marrow Neoplasms; Gastrectomy; Humans; Immunochemistry; Lumbar Vertebrae; Male; Middle Aged; Stomach Neoplasms; Technetium Tc 99m Medronate; Tomography, Emission-Computed, Single-Photon

Topics: Female; Humans; Middle Aged; Plasmacytoma; Radionuclide Imaging; Radiopharmaceuticals; Stomach Neoplasms; Technetium Tc 99m Medronate; Tomography, X-Ray Computed

Topics: Adenocarcinoma; Artifacts; Bone Neoplasms; Humans; Humerus; Male; Middle Aged; Radionuclide Imaging; Sensitivity and Specificity; Stomach Neoplasms; Technetium Tc 99m Medronate

At present, algorithms used in nuclear medicine to reconstruct single photon emission computerized tomography (SPECT) data are usually based on one of two principles: filtered backprojection and iterative methods. In this paper a different algorithm, applying an artificial neural network (multilayer perception) and error backpropagation as training method are used to reconstruct transaxial slices from SPECT data. The algorithm was implemented on an Elscint XPERT workstation (i486, 50 MHz), used as a routine digital image processing tool in our departments. Reconstruction time for a 64 x 64 matrix is approximately 45 s/transaxial slice. The algorithm has been validated by a mathematical model and tested on heart and Jaszczak phantoms. Phantom studies and very first clinical results ((111)In octreotide SPECT, 99mTc MDP bone SPECT) show in comparison with filtered backprojection an enhancement in image quality.

Topics: Algorithms; Carcinoid Tumor; Computer Simulation; Heart; Humans; Image Processing, Computer-Assisted; Neural Networks, Computer; Octreotide; Phantoms, Imaging; Radiopharmaceuticals; Spine; Stomach Neoplasms; Technetium Tc 99m Medronate; Tomography, Emission-Computed, Single-Photon

Topics: Aged; Bone and Bones; Bone Neoplasms; Female; Humans; Radionuclide Imaging; Radiopharmaceuticals; Stomach Neoplasms; Technetium Tc 99m Medronate

This case report describes the clinical, scintigraphic, and pathologic findings in a patient with an unexpected finding of a cutaneous malignant melanoma.. Multiple imaging studies were done, as was a pathologic examination of a suspicious pigmented lesion on the patient's back.. A Tc-99m MDP bone scan showed diffuse uptake in the skeleton, lungs, kidneys, and stomach.. Metastatic calcification, as shown by isotope scintigraphy, is an unusual manifestation of metastatic cancer from a primary cutaneous melanoma.

Topics: Adult; Bone and Bones; Female; Humans; Kidney Neoplasms; Lung Neoplasms; Melanoma; Radionuclide Imaging; Radiopharmaceuticals; Renal Insufficiency; Skin Neoplasms; Stomach Neoplasms; Technetium Tc 99m Medronate

We report an interesting case of osteomalacia in which flare response was seen during therapy. The first 99mTc-methylene diphosphonate bone scan showed increased bilateral and symmetric uptake in the ribs, clavicles and iliac bones. Thoracic CT showed symmetric radiolucent seams (Looser's zones) in both ribs, which were pathognomonic of osteomalacia. After initiation of therapy with vitamin D, the patient's subjective symptoms gradually were relieved. On a second bone scan 4 mo. after initiation of therapy, the hot spots in the ribs remained unchanged. Uptake in the bilateral clavicles had become more intense, and new hot spots were recognized in the right lower ribs and left tibia. A third bone scan after 10 mo. demonstrated an obvious decrease in the number and intensity of the hot spots. Increased uptakes in the second scan were thought to be a flare response caused by therapy.

Topics: Aged; Bone and Bones; Follow-Up Studies; Gastrectomy; Humans; Malabsorption Syndromes; Male; Osteomalacia; Pain; Radionuclide Imaging; Radiopharmaceuticals; Stomach Neoplasms; Technetium Tc 99m Medronate; Time Factors; Tomography, X-Ray Computed; Vitamin D

We counted the lesions at the time of detection of bone metastases and calculated the rate of increase in the number of bone metastases from changes in serial bone scintigrams, and investigated the usefulness of serial scintigrams as a prognostic indicator in patients with metastatic bone tumors. Subjects were 112 patients with bone metastases from four types of primary lesion: 21 with prostate cancer, 27 breast cancer, 39 lung cancer and 25 stomach cancer. Of these, 18 (prostate), 19 (breast), nine (lung) and eight (stomach) underwent serial bone scintigrams in which bone metastases were first detected and identified as progressing. The numbers of lesions at the time of detection of bone metastases for prostate and stomach cancers were significantly greater than those for lung cancer. The rate of increase in the number of bone metastases for stomach cancer was significantly higher than that for prostate or breast cancers. There was no correlation between the survival time after the detection of bone metastases and the number of lesions at the time of detection in the four types of cancer. However, in prostate cancer, a negative correlation existed between the survival time after the detection of bone metastases and the rate of increase in the number of bone metastases. Thus, in patients with bone metastases from prostate cancer, it appears that the rate of increase in the number of bone metastases, estimated from serial bone scintigrams, was indicative of prognosis.

Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Bone and Bones; Bone Neoplasms; Breast Neoplasms; Disease Progression; Evaluation Studies as Topic; Female; Follow-Up Studies; Humans; Injections, Intravenous; Lung Neoplasms; Male; Middle Aged; Prognosis; Prostatic Neoplasms; Radionuclide Imaging; Radiopharmaceuticals; Regression Analysis; Stomach Neoplasms; Survival Rate; Technetium Tc 99m Medronate; Whole-Body Counting

Signet-ring cell carcinoma of the breast, first recognized in 1976, behaves aggressively and is associated with a poor prognosis. The tumor is a rare type of breast cancer and often metastasizes to the gastrointestinal tract and female genital tract. The authors report a case of a 48-year-old woman with bilateral signet-ring cell carcinoma of the breasts with multiple skeletal metastases and gastric metastasis. The breast cancer was depicted on a Tc-99m MIBI scintimammogram.

Topics: Bone Neoplasms; Breast Neoplasms; Carcinoma, Signet Ring Cell; Female; Humans; Middle Aged; Neoplasms, Multiple Primary; Radionuclide Imaging; Stomach Neoplasms; Technetium Tc 99m Medronate; Technetium Tc 99m Sestamibi

A patient with osteomalacia secondary to vitamin D deficiency after gastrectomy for gastric cancer is presented. Initial bone scintigrams showed both asymmetric and symmetric focal areas of intense uptake due to pseudofractures reminiscent of bone metastases. Radiographs only confirmed the presence of pseudofractures at some, but not all, of the abnormal sites demonstrated by bone scintigraphy. At first, metastatic bone disease was suspected. However, the appearance of repeated bone scintigram was normalized after treatment with vitamin D. A diagnosis of osteomalacia was established. The present case serves to illustrate that symmetric focal lesions are important features of pseudofractures secondary to osteomalacia, and comparison with radiographs and repeated bone scintigraphy are necessary in distinguishing between bone metastases and pseudofractures.

Topics: Bone and Bones; Bone Neoplasms; Diagnosis, Differential; Fractures, Bone; Gastrectomy; Humans; Male; Middle Aged; Osteomalacia; Postoperative Complications; Radionuclide Imaging; Stomach Neoplasms; Technetium Tc 99m Medronate; Vitamin D Deficiency

The authors conducted a retrospective review of 234 bone scans of stomach cancer patients who had been diagnosed at the Seoul National University Hospital. In 106 of the 234 cases (45.3%), there were abnormal bone scan results, suggestive of bone metastases. The most common site of bone metastases was the spine, followed by the ribs, pelvis, femur, and skull. These sites were similar to those known for other malignant diseases. The incidence of bone metastases increased according to the duration of disease, especially within 12 months after diagnosis in patients with stage III gastric cancer. The incidence of bone metastases increased as the clinical stage increased. However, the incidence of metastases did not relate to gastric cancer pathologic type. The authors found 6 cases of "superscan" in the 234 bone scans (2.6%). The bone scan findings correlated positively with the level of serum alkaline phosphatase.

Topics: Bone Neoplasms; Female; Humans; Male; Middle Aged; Radionuclide Imaging; Retrospective Studies; Stomach Neoplasms; Technetium Tc 99m Medronate

Topics: Aged; Bone and Bones; Humans; Leiomyoma; Male; Radionuclide Imaging; Stomach Neoplasms; Technetium Tc 99m Medronate

Within the imaging literature, the super bone scan has emerged as a distinct type of bone scan with a specific differential diagnosis. Previous reviews have included prostate, breast, bladder and colon cancer, and lymphoma among the causes of a super bone scan but have not included stomach cancer. We report a super bone scan caused by late recurrence of stomach cancer in the bone marrow. Because the management of stomach cancer is significantly different than the management of other causes of a super bone scan, the distinction is clinically relevant. We conclude that stomach cancer should be considered in the differential diagnosis of a super bone scan.

Topics: Adenocarcinoma; Bone and Bones; Bone Marrow; Bone Neoplasms; Diagnosis, Differential; Humans; Male; Middle Aged; Radionuclide Imaging; Stomach Neoplasms; Technetium Tc 99m Medronate; Tomography, X-Ray Computed

Topics: Adenocarcinoma, Mucinous; Aged; Bone Neoplasms; Diphosphonates; Female; Humans; Lymphatic Metastasis; Radionuclide Imaging; Stomach Neoplasms; Technetium; Technetium Tc 99m Medronate

Increased accumulation of radioactivity was observed in malignant pleural and ascitic effusion as to a patient with stomach cancer and in malignant pleural effusions as to 2 patients (1 with breast cancer and another with lung cancer) during the performance of routine whole-body bone scans with 99mTc methylene diphosphonate. This finding should strongly suggest malignancy.

Topics: Adult; Ascites; Bone and Bones; Breast Neoplasms; Diphosphonates; Female; Humans; Lung Neoplasms; Male; Middle Aged; Pleural Effusion; Stomach Neoplasms; Technetium; Technetium Tc 99m Medronate; Tomography, Emission-Computed

When the bone scintigram reveals high diffuse skeletal activity, it may be misinterpreted as normal. Some authors have reported such scintigrams in articles entitled "Significance of absent or faint kidney sign on bone scan" and "False negative bone scintigram". Three cases with bone metastasis showing high diffuse skeletal activity are presented in this paper. The recognition of abnormally high diffuse skeletal activity on bone scintigrams is discussed. The exposure time of all three cases was short when compared with normal cases, when the bone image was taken with a preset count. Therefore, exposure time is very important for objective differentiation between the cases showing high diffuse skeletal activity and normal cases.

Topics: Bone Neoplasms; Diphosphonates; Female; Humans; Male; Middle Aged; Prostatic Neoplasms; Radionuclide Imaging; Stomach Neoplasms; Technetium; Technetium Tc 99m Medronate; Time Factors

Accumulation of 99mTc-methylene diphosphonate was observed in liver metastasis resulting from stomach carcinoma. This accumulation was located around the lesion on an emission-computed tomogram. This has not been previously reported.

Topics: Adult; Diphosphonates; Humans; Liver Neoplasms; Male; Stomach Neoplasms; Technetium; Technetium Tc 99m Medronate; Tomography, Emission-Computed

Topics: Bone and Bones; Diphosphonates; Female; Humans; Male; Middle Aged; Prostatic Neoplasms; Radionuclide Imaging; Stomach Neoplasms; Technetium; Technetium Tc 99m Medronate

Topics: Abdomen; Adenocarcinoma; Adult; Aged; Ascitic Fluid; Diphosphonates; Female; Humans; Leukemia, Myeloid; Lymphoma, Large B-Cell, Diffuse; Male; Middle Aged; Ovarian Neoplasms; Radionuclide Imaging; Stomach Neoplasms; Technetium; Technetium Tc 99m Medronate; Teratoma; Testicular Neoplasms; Urethral Neoplasms