technetium-tc-99m-medronate and Spondylarthropathies

The aim of this study was to assess the effectiveness of radiation synovectomy (RSV) in the treatment of recurrent joint effusions, using 90Y in patients with chosen inflammatory joint diseases. The group of treated patients consisted of 30 people. Qualification for the treatment was based on clinical assessment, three-phase bone scintigraphy (BS3) and biochemical analysis. Intra-articular injection of 90Y was performed. Biochemical analysis was repeated after 48 h, 4 and 24 weeks, whereas BS3 was repeated after 24 weeks. Changes in the second phase of BS3 were assessed visually, using a four-degree scale and in the third phase, semiquantitatively with J/B ratio. The changes in the blood pool phase before RSV were 3.4 +/- 0.6 and after the therapy 2.00 +/- 0.8 (P < 0.001). The J/B ratio was: before RSV 2.58 +/- 08; after treatment 2.09 +/- 0.9 (P < 0.05). RSV is an effective method to treat recurrent effusions in patients with RA and SPA.

Topics: Adult; Aged; Arthritis, Rheumatoid; Citrates; Female; Humans; Injections, Intra-Articular; Knee Joint; Male; Middle Aged; Organometallic Compounds; Radioisotopes; Radionuclide Imaging; Spondylarthropathies; Synovial Fluid; Synovial Membrane; Technetium Tc 99m Medronate; Treatment Outcome