technetium-tc-99m-medronate and Skin-Neoplasms

A 6-year-old castrated Goldendoodle dog was presented for left-sided lameness of 3 weeks' duration. Focal, moderate to marked increased

Topics: Animals; Bone Neoplasms; Dog Diseases; Dogs; Fatal Outcome; Femur; Hair Diseases; Lameness, Animal; Lung Neoplasms; Male; Pilomatrixoma; Radionuclide Imaging; Scapula; Skin Neoplasms; Technetium Tc 99m Medronate

Topics: Humans; Lymphatic Metastasis; Male; Melanoma; Middle Aged; Radionuclide Imaging; Skin Neoplasms; Technetium Tc 99m Medronate; Whole Body Imaging

Lymphoscintigraphy for sentinel node (SN) localization was performed on a 60-y-old man with a melanoma on his back. Skin contamination occurred as a result of the radiopharmaceutical dose administration. Skin contamination could result in a misinterpretation of the SN location. Careful observation of the procedure avoided a misinterpretation with this study.

Topics: Artifacts; Humans; Lymphoscintigraphy; Male; Melanoma; Middle Aged; Radiopharmaceuticals; Sentinel Lymph Node Biopsy; Skin Neoplasms; Technetium Tc 99m Medronate; Technetium Tc 99m Sulfur Colloid

This case report describes the clinical, scintigraphic, and pathologic findings in a patient with an unexpected finding of a cutaneous malignant melanoma.. Multiple imaging studies were done, as was a pathologic examination of a suspicious pigmented lesion on the patient's back.. A Tc-99m MDP bone scan showed diffuse uptake in the skeleton, lungs, kidneys, and stomach.. Metastatic calcification, as shown by isotope scintigraphy, is an unusual manifestation of metastatic cancer from a primary cutaneous melanoma.

Topics: Adult; Bone and Bones; Female; Humans; Kidney Neoplasms; Lung Neoplasms; Melanoma; Radionuclide Imaging; Radiopharmaceuticals; Renal Insufficiency; Skin Neoplasms; Stomach Neoplasms; Technetium Tc 99m Medronate

The authors report the casual discovery in 1991 of a metastasis during Tc-99m MDP imaging of a 57-year-old woman who underwent surgery in 1983 for cutaneous melanoma on the right calf. The scan did not show bone alterations but did reveal an area of hyperactive uptake in the soft tissue of the medial surface of the thigh, where slightly altered pigmentation was also apparent. A subsequent immunoscan with Tc-99m-F(ab')2 225.28S confirmed increased uptake at this site. The lesion was removed and was histologically diagnosed as a skin metastasis from melanoma. Inguinal adenopathy appeared 6 months later. The uptake of Tc-99m MDP by both primary and metastases tumors has been described, although this may be the first report concerning melanoma. The uptake mechanism is not known.

Topics: Antibodies, Monoclonal; Female; Humans; Immunoglobulin Fab Fragments; Lymphatic Metastasis; Melanoma; Middle Aged; Radioimmunodetection; Skin Neoplasms; Soft Tissue Neoplasms; Technetium Tc 99m Medronate; Thigh

Dermatofibrosarcoma protuberans occurs early in life, is an unusual soft tissue tumor, and is uncommonly seen distal to knees. The authors present a rare case of dermatofibrosarcoma protuberans of the toe with different imaging modalities.

Topics: Adult; Bone and Bones; Dermatofibrosarcoma; Female; Foot Diseases; Gallium Radioisotopes; Humans; Magnetic Resonance Imaging; Radionuclide Imaging; Skin Neoplasms; Technetium Tc 99m Medronate; Thallium Radioisotopes; Toes

Topics: Adult; Female; Hemangioma; Humans; Skin Neoplasms; Soft Tissue Neoplasms; Technetium Tc 99m Medronate; Thigh; Tomography, Emission-Computed, Single-Photon

Topics: Adult; Bone Neoplasms; Diagnosis, Differential; Fibroma; Humans; Male; Melanoma; Pseudarthrosis; Radionuclide Imaging; Skin Neoplasms; Technetium Tc 99m Medronate

The clinical records of 94 patients with regionally advanced melanoma (nodal disease or regional satellites) were reviewed to determine the value of preoperative bone and liver imaging. Of 68 bone scans obtained, none were suggestive of metastases. of 97 liver imaging studies (computed tomography, scintiscan, or sonography) in 88 patients, only two were found to have demonstrable metastases. Liver enzyme elevation was present in both of these patients. Bone and liver imaging in the absence of signs or symptoms of dissemination by history, physical examination, chest x-ray, and enzyme determination for regionally advanced melanoma appears to be of little value unless the patient is involved in a protocol study.

Topics: Alkaline Phosphatase; Bone Neoplasms; Female; Humans; Liver Neoplasms; Male; Melanoma; Middle Aged; Radionuclide Imaging; Skin Neoplasms; Technetium Tc 99m Medronate; Technetium Tc 99m Sulfur Colloid

Topics: Adenocarcinoma; Female; Humans; Middle Aged; Orbital Neoplasms; Radionuclide Imaging; Skin Neoplasms; Technetium Tc 99m Medronate

Five hundred and eighty birthmarks were reviewed; 356 were hemangiomas and 224 were malformations. Bony alterations occurred in association with only 1 percent of hemangiomas, in contrast with 34 percent of patients with vascular malformations. These alterations in bone development were classified according to size, shape, and density changes. Hypertrophy and distortion were typical of lymphatic malformations. Hypoplasia and demineralization were characteristic findings in the extremity venous malformations. Destructive and intraosseous changes were more commonly noted in the arterial or high-flow lesions. Possible mechanisms of altered skeletal growth include mechanical, physiological, and developmental processes.

Topics: Adolescent; Adult; Arm; Arteriovenous Malformations; Bone and Bones; Child; Child, Preschool; Diphosphonates; Female; Head and Neck Neoplasms; Hemangioma; Humans; Infant; Leg; Male; Middle Aged; Radionuclide Imaging; Retrospective Studies; Skin Neoplasms; Technetium; Technetium Tc 99m Medronate; Terminology as Topic