technetium-tc-99m-medronate and Sinusitis

To investigate the clinical significance of bone involvement in chronic rhinosinusitis, 99mTc-MDP bone single photon emission computed tomography (SPECT) was studied in 43 patients diagnosed as having chronic rhinosinusitis. Quantitative isotope uptake indices calculated on SPECT were compared between the patient and a control group, and between patients with a good postoperative outcome and those with a poor outcome. The patient group showed a significantly higher isotope uptake than the control group. The uptake of isotope in the ethmoid sinus areas in patients who had a poor postoperative outcome was significantly higher than those who had a good outcome. Our study suggests that patients with chronic rhinosinusitis have apparent bony involvement, and patients with more severe bone involvement may have a poorer treatment outcome.

Topics: Adult; Chronic Disease; Endoscopy; Female; Humans; Male; Middle Aged; Nasal Bone; Otorhinolaryngologic Surgical Procedures; Rhinitis; Sinusitis; Technetium Tc 99m Medronate; Tomography, Emission-Computed, Single-Photon; Treatment Outcome

Sinonasal tuberculosis is a rare disease; its association with osteomyelitis of surrounding bone and cervical lymphadenopathy has been reported rarely. In this article, we report a case of sinonasal tuberculosis that was complicated by osteomyelitis of the ethmoid bone and cervical lymphadenopathy. Infection of the bone was demonstrated by biopsy and (99m)Tc-MDP bone single photon emission computed tomography (SPECT), and cervical lymphadenopathy was confirmed by histology. This case will be discussed with specific emphasis on the imaging characteristics.

Topics: Adult; Ethmoid Bone; Ethmoid Sinusitis; Female; Humans; Magnetic Resonance Imaging; Maxillary Sinusitis; Neck; Nose Diseases; Osteomyelitis; Sinusitis; Technetium Tc 99m Medronate; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; Tuberculosis; Tuberculosis, Lymph Node

Radionuclide scintigraphy is useful in the diagnosis of sinusitis. Three cases are described, using different radionuclide agents (99mTc-MDP, 67Ga-citrate and 111In-leukocytes) in which sinusitis was discovered, though clinically unsuspected. The advantages and limitations of these agents are briefly reviewed.

Topics: Adolescent; Aged; Citrates; Citric Acid; Female; Humans; Indium Radioisotopes; Infant; Leukocytes; Male; Radionuclide Imaging; Sinusitis; Technetium Tc 99m Medronate