technetium-tc-99m-medronate and Sclerosis

Juvenile mandibular chronic osteomyelitis is a rare entity that predominantly affects children and adolescents, but little is known about the factors that contribute to the recurrent course and eventual resolution of this disease. Here, we describe new findings of soft tissue and mandibular nerve canal involvement.. Four patients with mandibular diffuse sclerosing osteomyelitis are presented; all were followed with CT, a few also with MRI and bone scan. We recorded imaging findings of lesion location, pattern of bone formation, presence and evolution of lytic lesions, mandibular nerve, and soft tissue involvement.. In all patients we found enlargement of the mandibular nerve canal and soft tissue changes on CT and MRI (when available). All patients had ground glass bone patterns in conjunction with lamellated/onion skin new periosteal bone formation on CT, and all patients with follow-up CT had change in lytic lesion locations.. Mandibular nerve canal enlargement, soft tissue abnormalities, and change in location of lytic lesions may represent a diagnostic pattern in mandibular diffuse sclerosing osteomyelitis (Garré) that was not previously entirely recognized as such.

Topics: Adolescent; Child; Child, Preschool; Chronic Disease; Diagnostic Imaging; Female; Follow-Up Studies; Humans; Image Enhancement; Lymph Nodes; Magnetic Resonance Imaging; Male; Mandible; Mandibular Diseases; Mandibular Nerve; Masseter Muscle; Osteogenesis; Osteolysis; Osteomyelitis; Periosteum; Radionuclide Imaging; Radiopharmaceuticals; Recurrence; Sclerosis; Technetium Tc 99m Medronate; Tomography, Spiral Computed; Whole Body Imaging

Fibrous dysplasia is a benign bone disorder. It is diagnosed by distinctive X-ray radiography, CT, and MRI findings. Although bone scintigraphy helps to identify the tumor origin according to accelerated bone turnover, the glucose metabolism in fibrous dysplasia has not yet been investigated. We reported a case of fibrous dysplasia in craniofacial bone which showed signs of the acceleration of bone mineral turnover without elevated glucose utilization by Technetium-99m-HMDP SPECT and Fluorine-18-FDG PET. We concluded that the growth of fibrous dysplasia needed the acceleration of bone mineral turnover without an increase in glucose metabolism.

Topics: Bone Density; Facial Bones; Female; Fibrous Dysplasia, Polyostotic; Fluorodeoxyglucose F18; Glucose; Humans; Hyperplasia; Middle Aged; Radiopharmaceuticals; Sclerosis; Skull; Technetium Tc 99m Medronate; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed

The literature on diffuse sclerosing osteomyelitis of the mandible has included at least two groups of lesions: (1) those from which bacterial infectious agents are rarely isolated (chronic-tendoperiostitis); and (2) those from which bacteria are readily isolated (true diffuse sclerosing osteomyelitis). The latter should be distinguished from secondarily infected florid osseous dysplasia. In this article the features of 16 patients with sclerotic jawbone lesions associated with symptoms of infection are analyzed. Eleven patients showed a large area of sclerosis of the mandible that was not restricted to the alveolar process and was surrounding an infectious focus. The histologic pattern revealed a deposition of reactive bone. These lesions are considered to represent true diffuse sclerosing osteomyelitis. The remaining five patients showed sclerotic lesions restricted to the alveolar process in one or more quadrants of the jaws. Apart from inflammation and reactive changes, histologic pattern revealed a fibroblastic stroma with bone and cementum-like structures that are formed by metaplasia. These lesions are considered to represent secondarily infected florid osseous dysplasia.

Topics: Adolescent; Adult; Aged; Diagnosis, Differential; Female; Fibrous Dysplasia of Bone; Humans; Male; Mandibular Diseases; Middle Aged; Osteomyelitis; Periapical Periodontitis; Pericoronitis; Radiography, Panoramic; Sclerosis; Technetium Tc 99m Medronate

Thirteen patients with isolated pain and swelling of a sterno-clavicular clavicular joint have been reviewed. Three groups were identified. Group 1 comprised four patients, all of whom had a short history of less than six weeks and suffered a pyarthrosis or malignant disease; group 2, four patients who were shown to have features of condensing osteitis of the clavicle (Cone et al, 1983); and group 3, five patients, had degenerative arthritis of a sterno-clavicular joint. The only difference between groups 2 and 3 were that patients in group 3 had a rather longer history, both articular surfaces were involved and showed a possible increase in the incidence of degenerative joint disease elsewhere. It is suggested that condensing osteitis is but a part of a spectrum of degenerative disease of the sterno-clavicular joints, akin to discogenic vertebral body sclerosis (McCarthy & Dorfman, 1982).

Topics: Adult; Aged; Arthritis; Female; Gallium Radioisotopes; Humans; Male; Middle Aged; Osteitis; Pain; Radiography; Radionuclide Imaging; Sclerosis; Sternoclavicular Joint; Technetium Tc 99m Medronate

Thirty-six patients with bacterial spondylitis and eight patients with hemispherical spondylosclerosis (Dihlmann 1981) were examined by conventional x-ray techniques, computed tomography, 99mTc-MDP scintigraphy and 67Gallium scintigraphy. Conventional radiology is adequate for making the diagnosis. Where there is doubt, however, and for observing the progress of the disease, CT and scintigraphy may be used. Hemispherical spondylosclerosis can be identified by means of these additional methods.

Topics: Adult; Aged; Diagnosis, Differential; Diphosphonates; Gallium Radioisotopes; Humans; Middle Aged; Radionuclide Imaging; Sclerosis; Spine; Spondylitis; Technetium; Technetium Tc 99m Medronate; Tomography, X-Ray Computed; Tuberculosis, Spinal

Topics: Diphosphonates; Femur Neck; Humans; Male; Middle Aged; Radiography; Radionuclide Imaging; Sclerosis; Technetium; Technetium Tc 99m Medronate