technetium-tc-99m-medronate and Sarcoidosis

Topics: Adult; Cervical Vertebrae; Female; Humans; Magnetic Resonance Imaging; Radionuclide Imaging; Radiopharmaceuticals; Sarcoidosis; Spinal Fractures; Spinal Fusion; Technetium Tc 99m Medronate; Thoracic Vertebrae

Topics: Adult; Bone Diseases; Calcaneus; Citrates; Gallium; Humans; Incidental Findings; Male; Radionuclide Imaging; Radiopharmaceuticals; Sarcoidosis; Technetium Tc 99m Medronate

Ga-67 scintigraphy is helpful in the assessment of active extrapulmonary sarcoidosis. Muscular involvement of sarcoidosis is often asymptomatic or nonspecific, and laboratory examinations do not provide convincing evidence of muscular involvement. The authors report a case of muscular sarcoidosis detected by Ga-67 scintigraphy. In a patient who had fever and arthralgia of both knee joints, Ga-67 scintigraphy showed mediastinal and hilar involvement of sarcoidosis with unexpected extensive muscular uptake. Magnetic resonance imaging revealed in detail intramuscular infiltration of sarcoid granuloma. Ga-67 scintigraphy is useful in detecting inflammatory muscular involvement of sarcoidosis and other multiorgan involvement.

Topics: Adult; Bone and Bones; Citrates; Gallium; Gallium Radioisotopes; Humans; Lung; Magnetic Resonance Imaging; Male; Muscle, Skeletal; Muscular Diseases; Radionuclide Imaging; Radiopharmaceuticals; Sarcoidosis; Technetium Tc 99m Medronate

Topics: Bone Diseases; Deferoxamine; Humans; Male; Middle Aged; Octreotide; Radionuclide Imaging; Radiopharmaceuticals; Sarcoidosis; Technetium Tc 99m Medronate

The authors describe a 38-year-old man who was referred to the nuclear medicine department because of pain and swelling of his fingers in both hands. Tc-99m MDP and Tl-201 scans were performed to evaluate the lesions. A Tc-99m MDP bone scan showed hyperemia and increased uptake in the lesions. A Tl-201 scan showed marked uptake in both early and delayed images in the lesions of his fingers. Bone biopsy and histologic examination confirmed sarcoidosis. This case indicates that Tl-201 uptake can be seen in bone lesions resulting from sarcoidosis.

Topics: Adult; Biopsy, Needle; Bone Diseases; Connective Tissue Diseases; Hand; Humans; Male; Radionuclide Imaging; Sarcoidosis; Sensitivity and Specificity; Technetium Tc 99m Medronate; Thallium Radioisotopes

Routine use of diagnostic radioisotope bone scanning in patients with sarcoidosis has not previously been evaluated. The aim of this study was to assess whether routine radioisotope bone scanning might be of value in the detection of osseous lesions in sarcoidosis.. 63 consecutive Caucasian patients (32 men) with a median age of 39 years (range 17-66) and biopsy proven pulmonary sarcoidosis were included. None had symptoms suggesting osseous sarcoidosis. Extrathoracic, non-osseous sarcoidosis was present in 24 patients; 13 patients were on oral steroids. Radioisotope bone scanning was performed with a gammacamera after intravenous injection of 99mTechnetium-methylenediphosphonate. An abnormal bone scan was followed by a radiograph of the region of interest.. 39 patients (61.9%) had normal bone scans. Minor bone scan abnormalities were found in 24 patients (38.1%). Of these, 11 patients had bone foci (8 in the vertebral spine, 9 in the ribs, 1 in a finger). Radiographically only one of these 11 patients had a bony lesion being typical of sarcoidosis, located in the second finger. 17 patients had joint foci. Radiographs of the joints showed sequelae after a fracture in 1 patient, and degenerative osteoarthritis in 1 patient. There was no difference between clinical and paraclinical variables in patients with normal and abnormal bone scans.. There appears to be no indication for routine radioisotope bone scanning in patients with sarcoidosis. Scanning should be restricted to patients with clinical suspicion of osseous sarcoidosis.

Topics: Adult; Bone and Bones; Bone Diseases; Diagnostic Tests, Routine; Female; Humans; Male; Radionuclide Imaging; Radiopharmaceuticals; Sarcoidosis; Sarcoidosis, Pulmonary; Technetium Tc 99m Medronate

We describe a patient with unexplained hypercalcemia who under went bone scintigraphy, which demonstrated marked tracer uptake within the hilar lymph nodes. The pattern strongly suggested sarcoidosis, which was subsequently confirmed by bronchoscopy-directed biopsy.

Topics: Adult; Bone and Bones; Female; Humans; Hypercalcemia; Lymphatic Diseases; Radionuclide Imaging; Renal Insufficiency; Sarcoidosis; Technetium Tc 99m Medronate

Sarcoidosis is rarely recognized as an osseous manifestations alone. Patients with osseous involvement usually have a chronic multivisceral form of the disease. The authors report a case of osseous sarcoidosis without other visceral involvement. A bone scan was requested to evaluate the extent of the bone involvement and explore buttocks pain.

Topics: Arthralgia; Bone Diseases; Buttocks; Chronic Disease; Foot Diseases; Hand; Humans; Male; Middle Aged; Pain; Radionuclide Imaging; Sacroiliac Joint; Sarcoidosis; Technetium Tc 99m Medronate

We report on 99mTc-MDP uptake in lungs and stomach in a patient with hypercalcaemia and renal failure due to elevated 1,25(OH)2vitD3 because of sarcoidosis. Presently, this typical scan pattern has only been described in patients with malignancies, parathyroid adenoma and drug-induced vitamin D intoxication. We offer possible explanations for the findings in our patient.

Topics: Aged; Bone and Bones; Calcinosis; Humans; Hypercalcemia; Lung Diseases; Male; Radionuclide Imaging; Sarcoidosis; Stomach Diseases; Technetium Tc 99m Medronate

We present a case of painful osseous sarcoid involving the tibiae bilaterally. Lesions were initially found on plain radiographs and on a 99mTc-MDP bone scan. The patient was also found to have CNS involvement of sarcoidosis in the form of diabetes insipidus and panhypopituitarism. CNS lesions were demonstrated on CT and MR images.

Topics: Bone Diseases; Brain; Brain Diseases; Female; Humans; Knee Joint; Middle Aged; Radionuclide Imaging; Sarcoidosis; Technetium Tc 99m Medronate; Tomography, X-Ray Computed

94 patients diagnosed as having sarcoidosis were studied in Galicia in order to evaluate the frequency of bone manifestations, as well as to analyse the clinical and radiological features. Bone lesions were found in 10 patients (10.6%) with a median age of 47.4 years, the predominant sex being female in this group (70%). The lesions were of two types: a) osteolytic on metacarpal (4 cases), nasal bones (1 case), sacrum (1 case), femur (1 case); b) osteosclerosis on femur and fibula (1 case), acrosclerosis (3 cases), metacarpal (1 case). The first lesions were associated to chronic types of sarcoidosis with skin and lung involvements. The second lesions were associated to a sub-acute type of Löfgren. We highlight the behaviour of both types of bone lesions and comment on the physiopathology of the sclerotic lesions.

Topics: Age Factors; Biopsy; Bone and Bones; Bone Diseases; Humans; Incidence; Osteolysis; Osteosclerosis; Radiography; Radionuclide Imaging; Sarcoidosis; Sex Factors; Spain; Technetium Tc 99m Medronate

Topics: Bone and Bones; Gallium Radioisotopes; Muscular Diseases; Radionuclide Imaging; Sarcoidosis; Technetium Tc 99m Medronate

The application of radioisotope scanning to osseous involvement from systemic sarcoidosis has been infrequently described in the scientific literature. Most commonly, the small bones of the hands and feet are affected if sarcoidosis involves the skeleton. Nonetheless, there are also occasional manifestations of sarcoid in the skull, long bones, and vertebral bodies. This paper describes a case of sarcoid involving the lung parenchyma with multiple lesions in the skull and ribs demonstrated by bone scanning with Tc-99m MDP. Following treatment with steroids, the bone scan showed complete resolution of the rib lesions and almost complete resolution of the lesions in the calvarium.

Topics: Bone Diseases; Diphosphonates; Female; Humans; Lung Diseases; Middle Aged; Pentetic Acid; Radionuclide Imaging; Sarcoidosis; Skull; Technetium; Technetium Tc 99m Medronate; Technetium Tc 99m Pentetate