technetium-tc-99m-medronate and Retroviridae-Infections

Two patients with T-cell malignancy having radiographic manifestations of generalized and localized bone demineralization are reported. One, a 53-year-old man, had marked osteoporosis and severe hypercalcemia, but no clinical evidence of leukemia throughout his illness. At autopsy there was no definite evidence of bone involvement. Histologic proof was obtained from abdominal skin which revealed "adult T-cell leukemia/lymphoma (ATLL)." The second case, a 33-year-old man, complained of arthralgia in his hands and feet; radiographs showed severe localized demineralization and pathologic fractures. Specimens of his peripheral blood, cervical lymph nodes, and bone marrow revealed ATLL cells.

Topics: Adult; Bone and Bones; Deltaretrovirus; Humans; Leukemia; Male; Middle Aged; Minerals; Osteoporosis; Radiography; Radionuclide Imaging; Retroviridae Infections; Technetium Tc 99m Medronate